| Literature DB >> 29602038 |
Marcos Vinícius Palmeira de Mello1, Barbara de Azevedo Abrahim-Vieira2, Thaisa Francielle Souza Domingos2, Jessica Barbosa de Jesus2, Ana Carolina Corrêa de Sousa2, Carlos Rangel Rodrigues2, Alessandra M Teles de Souza3.
Abstract
Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20 pathogenic species of Leishmania sp. Due to the limitations of the current treatments available, chalcone moiety has been drawn with a lot of attention due to the simple chemistry and synthesis, being reported with antileishmanial activity in particular against amastigote form. This review aims to provide an overview towards antileishmanial activity of chalcones derivatives against amastigote form for Leishmania major, L. amazonensis, L. panamensis, L. donovani and L. infantum as well as their structure-activity relationship (SAR), molecular targets and in silico ADMET evaluation. In this way, it is expected that this review may support the research and development of new promising chalcones candidates a leishmanicidal drugs.Entities:
Keywords: ADMET; Drug design; Leishmania; SAR
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Year: 2018 PMID： 29602038 DOI： 10.1016/j.ejmech.2018.03.047
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514