Chantal B van Houten1, Christiana Naaktgeboren2, Brigitte J M Buiteman1, Maaike van der Lee1, Adi Klein3, Isaac Srugo4, Irena Chistyakov4, Wouter de Waal5, Clemens B Meijssen6, Pieter W Meijers7, Karin M de Winter-de Groot8, Tom F W Wolfs1, Yael Shachor-Meyouhas9, Michal Stein10, Elisabeth A M Sanders1, Louis J Bont1. 1. From the Department of Pediatric Immunology and Infectious Diseases, University Medical Centre Utrecht, Utrecht, The Netherlands. 2. Department Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, The Netherlands. 3. Department of Pediatrics, Hillel Yaffe Medical Centre, Hadera, Israel. 4. Department of Pediatrics, Bnai Zion Medical Centre, Haifa, Israel. 5. Department of Pediatrics, Diakonessenhuis, Utrecht, The Netherlands. 6. Department of Pediatrics, Meander Medical Centre, Amersfoort, The Netherlands. 7. Department of Pediatrics, Hospital Gelderse Vallei, Ede, The Netherlands. 8. Department of Pediatric Pulmonary Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands. 9. Department of Pediatric Infectious Disease, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel. 10. Department of Infectious Diseases Hillel Yaffe Medical Centre, Hadera, Israel.
Abstract
BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) during the first year of life. Antibiotic treatment is recommended in cases suspected of bacterial coinfection. The aim of this prospective study was to estimate the incidence of bacterial coinfections and the amount of antibiotic overuse in children infected with RSV using expert panel diagnosis. METHODS: Children 1 month of age and over with LRTI or fever without source were prospectively recruited in hospitals in the Netherlands and Israel. Children with confirmed RSV infection by Polymerase Chain Reaction (PCR) on nasal swabs were evaluated by an expert panel as reference standard diagnosis. Three experienced pediatricians distinguished bacterial coinfection from simple viral infection using all available clinical information, including all microbiologic evaluations and a 28-day follow-up evaluation. RESULTS: A total of 188 children (24% of all 784 recruited patients) were positive for RSV. From these, 92 (49%) were treated with antibiotics. All 27 children (29%) with bacterial coinfection were treated with antibiotics. Fifty-seven patients (62%) were treated with antibiotics without a diagnosis of bacterial coinfection. In 8 of the 92 (9%), the expert panel could not distinguish simple viral infection from bacterial coinfection. CONCLUSION: This is the first prospective international multicenter RSV study using an expert panel as reference standard to identify children with and without bacterial coinfection. All cases of bacterial coinfections are treated, whereas as many as one-third of all children with RSV LRTI are treated unnecessarily with antibiotics.
BACKGROUND:Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) during the first year of life. Antibiotic treatment is recommended in cases suspected of bacterial coinfection. The aim of this prospective study was to estimate the incidence of bacterial coinfections and the amount of antibiotic overuse in children infected with RSV using expert panel diagnosis. METHODS:Children 1 month of age and over with LRTI or fever without source were prospectively recruited in hospitals in the Netherlands and Israel. Children with confirmed RSV infection by Polymerase Chain Reaction (PCR) on nasal swabs were evaluated by an expert panel as reference standard diagnosis. Three experienced pediatricians distinguished bacterial coinfection from simple viral infection using all available clinical information, including all microbiologic evaluations and a 28-day follow-up evaluation. RESULTS: A total of 188 children (24% of all 784 recruited patients) were positive for RSV. From these, 92 (49%) were treated with antibiotics. All 27 children (29%) with bacterial coinfection were treated with antibiotics. Fifty-seven patients (62%) were treated with antibiotics without a diagnosis of bacterial coinfection. In 8 of the 92 (9%), the expert panel could not distinguish simple viral infection from bacterial coinfection. CONCLUSION: This is the first prospective international multicenter RSV study using an expert panel as reference standard to identify children with and without bacterial coinfection. All cases of bacterial coinfections are treated, whereas as many as one-third of all children with RSV LRTI are treated unnecessarily with antibiotics.
Authors: Abu Tholib Aman; Tri Wibawa; Herman Kosasih; Rizka Humardewayanti Asdie; Ida Safitri; Umi Solekhah Intansari; Yuli Mawarti; Pratiwi Sudarmono; Mansyur Arif; Dwiyanti Puspitasari; Bachti Alisjahbana; Ketut Tuti Merati Parwati; Muhammad Hussein Gasem; Dewi Lokida; Nurhayati Lukman; Teguh Sarry Hartono; Yan Mardian; C Jason Liang; Sophia Siddiqui; Muhammad Karyana; Chuen-Yen Lau Journal: Influenza Other Respir Viruses Date: 2020-07-14 Impact factor: 4.380
Authors: Danielle A Rankin; Nikhil K Khankari; Zaid Haddadin; Olla Hamdan; Ahmad Yanis; Samir Faouri; Asem Shehabi; John V Williams; Najwa Khuri-Bulos; Natasha B Halasa Journal: PLoS One Date: 2021-11-29 Impact factor: 3.752