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Literature DB >> 29601336

Molecular Profiling of Liquid Biopsy Samples for Precision Medicine.

Camila D M Campos, Joshua M Jackson, Małgorzata A Witek, Steven A Soper.

Abstract

In the context of oncology, liquid biopsies consist of harvesting cancer biomarkers, such as circulating tumor cells, tumor-derived cell-free DNA, and extracellular vesicles, from bodily fluids. These biomarkers provide a source of clinically actionable molecular information that can enable precision medicine. Herein, we review technologies for the molecular profiling of liquid biopsy markers with special emphasis on the analysis of low abundant markers from mixed populations.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Biomarkers, Tumor

Year: 2018 PMID： 29601336 PMCID： PMC5880307 DOI： 10.1097/PPO.0000000000000311

Source DB: PubMed Journal: Cancer J ISSN： 1528-9117 Impact factor: 3.360

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16 in total

1. Multilayer microfluidic array for highly efficient sample loading and digital melt analysis of DNA methylation.

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2. Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment.

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4. Label-Free Identification of Single Mononucleotides by Nanoscale Electrophoresis.

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5. Microfluidic-based solid phase extraction of cell free DNA.

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Review 6. Nanobodies for Medical Imaging: About Ready for Prime Time?

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7. Intra-individual variation of circulating tumour DNA in lung cancer patients.

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