Koji Higuchi1, Joshua Cates1, Gregory Gardner1, Alan Morris1, Nathan S Burgon1, Nazem Akoum1, Nassir F Marrouche2. 1. Comprehensive Arrhythmia and Research Management (CARMA) Center, University of Utah School of Medicine, Salt Lake City, Utah. 2. Comprehensive Arrhythmia and Research Management (CARMA) Center, University of Utah School of Medicine, Salt Lake City, Utah. Electronic address: Nassir.Marrouche@hsc.utah.edu.
Abstract
OBJECTIVES: The purpose of this study is to evaluate the spatial distribution of late gadolinium enhancement (LGE) of the left atrium (LA) by LGE-magnetic resonance imaging in an atrial fibrillation (AF) population. BACKGROUND: LGE of the LA can be a surrogate of pre-existing structural remodeling of LA. METHODS: LGE-magnetic resonance imaging scans were used for 160 patients with AF (mean age 66 ± 11 years) before AF ablation. To know the spatial distribution of LGE, the extent of LGE in 6 LA subregions was examined. Overall LGE distribution was also summarized as a spatial frequency histogram using an atlas of LA shape. These data were also compared between paroxysmal AF (87 patients) and persistent AF (73 patients). RESULTS: LGE coverage (%) in each subregion was as follows: 41.8 ± 18.9% in the left pulmonary vein (PV) antrum, 27.1 ± 16.7% in the left lateral wall, 25.8 ± 15.3% in the posterior wall, 19.7 ± 15.3% in the anterior wall, 17.1 ± 15.0% in the right PV antrum, and 12.0 ± 13.2% in the septum wall. LGE was heterogeneously distributed in the LA and was found with the highest frequency in the posterior wall near the inferior left PV antrum by the LGE histogram. A comparison of paroxysmal AF with persistent AF suggests that LGE was more expected in persistent AF compared with paroxysmal AF, particularly with a spread on the posterior and the anterior wall. CONCLUSIONS: LGE in the LA was heterogeneously distributed. LGE was highly distributed in the inferior left PV antrum near the posterior wall side, and spread on the posterior and anterior wall with AF progression.
OBJECTIVES: The purpose of this study is to evaluate the spatial distribution of late gadolinium enhancement (LGE) of the left atrium (LA) by LGE-magnetic resonance imaging in an atrial fibrillation (AF) population. BACKGROUND: LGE of the LA can be a surrogate of pre-existing structural remodeling of LA. METHODS: LGE-magnetic resonance imaging scans were used for 160 patients with AF (mean age 66 ± 11 years) before AF ablation. To know the spatial distribution of LGE, the extent of LGE in 6 LA subregions was examined. Overall LGE distribution was also summarized as a spatial frequency histogram using an atlas of LA shape. These data were also compared between paroxysmal AF (87 patients) and persistent AF (73 patients). RESULTS: LGE coverage (%) in each subregion was as follows: 41.8 ± 18.9% in the left pulmonary vein (PV) antrum, 27.1 ± 16.7% in the left lateral wall, 25.8 ± 15.3% in the posterior wall, 19.7 ± 15.3% in the anterior wall, 17.1 ± 15.0% in the right PV antrum, and 12.0 ± 13.2% in the septum wall. LGE was heterogeneously distributed in the LA and was found with the highest frequency in the posterior wall near the inferior left PV antrum by the LGE histogram. A comparison of paroxysmal AF with persistent AF suggests that LGE was more expected in persistent AF compared with paroxysmal AF, particularly with a spread on the posterior and the anterior wall. CONCLUSIONS: LGE in the LA was heterogeneously distributed. LGE was highly distributed in the inferior left PV antrum near the posterior wall side, and spread on the posterior and anterior wall with AF progression.
Authors: Zhaohan Xiong; Vadim V Fedorov; Xiaohang Fu; Elizabeth Cheng; Rob Macleod; Jichao Zhao Journal: IEEE Trans Med Imaging Date: 2019-02 Impact factor: 10.048
Authors: Aleksei V Mikhailov; Anuradha Kalyanasundaram; Ning Li; Shane S Scott; Esthela J Artiga; Megan M Subr; Jichao Zhao; Brian J Hansen; John D Hummel; Vadim V Fedorov Journal: J Mol Cell Cardiol Date: 2020-10-29 Impact factor: 5.000