Literature DB >> 29600759

Indandione and Its Derivatives - Chemical Compounds with High Biological Potential.

Robert Pluskota1, Marcin Koba1.   

Abstract

Indandione is a hydrocarbon classified as bicyclic aromatic β-diketone. It can be applied in many fields of science and industry. It is successfully used as a substrate in organic synthesis, pharmaceutical sciences and as a substrate for the production of dyes. Indandione derivatives and analogs are useful in medicine, chemistry and the judiciary. Among the indandione derivatives can find compounds that have interesting properties and many of them have biological activity (incl. anticancer, anticoagulation, anti-inflamatory, antimicrobial activities). Based on the indan-1,3-dione structure created acetylcholinesterase inhibitors. Indan-1,3-dione derivatives are also used as a derivating agent for the analysis of fatty aldehydes and a substance that is an element of dye-sensitized solar cells. This work presents a brief overview of construction, properties and activities of indandione and its derivatives. This work describes selected indandione derivatives that have properties useful in medicine and industry with particular regard to the anticoagulants and neuroprotective activities in AD. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Indandione; analogs; anticoagulant; derivatives; drugs; hybrid drug; polymers; synthesis.

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Year:  2018        PMID: 29600759     DOI: 10.2174/1389557518666180330101809

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN: 1389-5575            Impact factor:   3.862


  2 in total

1.  2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities.

Authors:  Olympia Kouzi; Eleni Pontiki; Dimitra Hadjipavlou-Litina
Journal:  Molecules       Date:  2019-12-03       Impact factor: 4.411

2.  Selected Drug-Likeness Properties of 2-Arylidene-indan-1,3-dione Derivatives-Chemical Compounds with Potential Anti-Cancer Activity.

Authors:  Robert Pluskota; Karol Jaroch; Piotr Kośliński; Blanka Ziomkowska; Agnieszka Lewińska; Stefan Kruszewski; Barbara Bojko; Marcin Koba
Journal:  Molecules       Date:  2021-08-30       Impact factor: 4.411

  2 in total

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