Literature DB >> 29600717

Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086.

Cong-Cong Liu1, Zhen-Zhen Zhang1, Yan-Yan Feng1, Qian-Qun Gu1, De-Hai Li1,2, Tian-Jiao Zhu1,2.   

Abstract

A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC50 value of 12.7 μM.

Entities:  

Keywords:  Antarctic; Secondary metabolites; cytotoxicity; marine-derived fungus

Mesh：

Substances：

Year:  2018        PMID： 29600717     DOI： 10.1080/14786419.2018.1455045

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  7 in total

1.  Biosynthesis of Xylariolide D in Penicillium crustosum Implies a Chain Branching Reaction Catalyzed by a Highly Reducing Polyketide Synthase.

Authors:  Sina A Stierle; Shu-Ming Li
Journal:  J Fungi (Basel)       Date:  2022-05-09

Review 2.  Occurrence and Properties of Thiosilvatins.

Authors:  Maria Michela Salvatore; Rosario Nicoletti; Marina DellaGreca; Anna Andolfi
Journal:  Mar Drugs       Date:  2019-11-26       Impact factor: 5.118

Review 3.  Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.

Authors:  Anton N Yurchenko; Elena V Girich; Ekaterina A Yurchenko
Journal:  Mar Drugs       Date:  2021-02-04       Impact factor: 5.118

Review 4.  Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review.

Authors:  Zhiqiang Song; Yage Hou; Qingrong Yang; Xinpeng Li; Shaohua Wu
Journal:  Mar Drugs       Date:  2021-07-21       Impact factor: 5.118

Review 5.  Diversity, Ecological Role and Biotechnological Potential of Antarctic Marine Fungi.

Authors:  Stefano Varrella; Giulio Barone; Michael Tangherlini; Eugenio Rastelli; Antonio Dell'Anno; Cinzia Corinaldesi
Journal:  J Fungi (Basel)       Date:  2021-05-17

6.  Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272.

Authors:  Mudassir Shah; Chunxiao Sun; Zichao Sun; Guojian Zhang; Qian Che; Qianqun Gu; Tianjiao Zhu; Dehai Li
Journal:  Mar Drugs       Date:  2020-01-23       Impact factor: 5.118

Review 7.  Deep-Sea Fungi Could Be the New Arsenal for Bioactive Molecules.

Authors:  Muhammad Zain Ul Arifeen; Yu-Nan Ma; Ya-Rong Xue; Chang-Hong Liu
Journal:  Mar Drugs       Date:  2019-12-20       Impact factor: 5.118
  7 in total

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