Chi-Huang Chen1,2, Chii-Ruey Tzeng1,2, Peng-Hui Wang3,4, Wei-Min Liu1,2, Heng-Yu Chang5,6, Huang-Hui Chen1, Ching-Hui Chen7,8,9. 1. Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, 11031, Taiwan. 2. Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. 3. Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, 11217, Taiwan. 4. Department of Obstetrics and Gynecology, School of Medicine, National Yang-Ming University, Taipei, 11221, Taiwan. 5. Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. 6. Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. 7. Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, 11031, Taiwan. kath0420@tmu.edu.tw. 8. Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan. kath0420@tmu.edu.tw. 9. Department of Obstetrics and Gynecology, Taipei Medical University Hospital and Taipei Medical University, No. 252, WuXing St, XinYi District, Taipei, 11031, Taiwan. kath0420@tmu.edu.tw.
Abstract
PURPOSE: To summarize available evidence from randomized-controlled trials which have evaluated triggering of final oocyte maturation with concomitant GnRH agonists and hCG in patients undergoing IVF, and to analyze whether dual triggering is as efficacious as hCG triggering in terms of oocyte and pregnancy outcomes. METHODS: A comprehensive literature search was performed to identify randomized-controlled trials comparing IVF outcomes between women receiving combined administration of hCG with GnRH agonists and those receiving hCG alone for triggering of final oocyte maturation. RESULTS: Four studies including 527 patients eligible for inclusion in meta-analysis were identified. No significant difference in the number of mature oocytes or fertilized oocytes retrieved was found between groups. Clinical pregnancy rate with dual triggering was significantly higher as compared with hCG-alone triggering (pooled OR = 0.48, 95% CI 0.31-0.77, P = 0.002), but there was no significant difference in the ongoing pregnancy rate between groups. CONCLUSION: Results of meta-analysis indicate comparable or significantly improved outcomes with the use of GnRH agonists plus hCG as compared with hCG alone for triggering of final oocyte maturation.
PURPOSE: To summarize available evidence from randomized-controlled trials which have evaluated triggering of final oocyte maturation with concomitant GnRH agonists and hCG in patients undergoing IVF, and to analyze whether dual triggering is as efficacious as hCG triggering in terms of oocyte and pregnancy outcomes. METHODS: A comprehensive literature search was performed to identify randomized-controlled trials comparing IVF outcomes between women receiving combined administration of hCG with GnRH agonists and those receiving hCG alone for triggering of final oocyte maturation. RESULTS: Four studies including 527 patients eligible for inclusion in meta-analysis were identified. No significant difference in the number of mature oocytes or fertilized oocytes retrieved was found between groups. Clinical pregnancy rate with dual triggering was significantly higher as compared with hCG-alone triggering (pooled OR = 0.48, 95% CI 0.31-0.77, P = 0.002), but there was no significant difference in the ongoing pregnancy rate between groups. CONCLUSION: Results of meta-analysis indicate comparable or significantly improved outcomes with the use of GnRH agonists plus hCG as compared with hCG alone for triggering of final oocyte maturation.
Entities:
Keywords:
GnRH agonist plus hCG; In vitro fertilization; Ovarian hyperstimulation syndrome; hCG
Authors: Condesmar M de Oliveira; Carlos A M de Oliveira; Larissa L Fonseca; Kelly R R de Souza; Moacir R M Radaelli Journal: JBRA Assist Reprod Date: 2021-04-27
Authors: Raoul Orvieto; Christos A Venetis; Human M Fatemi; Thomas D'Hooghe; Robert Fischer; Yulia Koloda; Marcos Horton; Michael Grynberg; Salvatore Longobardi; Sandro C Esteves; Sesh K Sunkara; Yuan Li; Carlo Alviggi Journal: Front Endocrinol (Lausanne) Date: 2021-05-10 Impact factor: 5.555