Vijaya Kumar Lukka1, Tripti Meriel Jacob2,3, Visalakshi Jeyaseelan4, Vedantam Rupa1. 1. Department of ENT, Christian Medical College, Vellore, India. 2. Department of Anatomy, Christian Medical College, Vellore, India. triptimj@gmail.com. 3. Department of Anatomy, School of Medical Sciences, UNSW, Sydney, Australia. triptimj@gmail.com. 4. Department of Biostatistics, Christian Medical College, Vellore, India.
Abstract
PURPOSE: Consensus has not been reached regarding the optimal reduction procedure for inferior turbinate hypertrophy in allergic rhinitis and whether such procedures result in improvement in mucosal architecture. METHODS: Twenty-nine patients aged 18-45 years (mean 26.8 years), with allergic rhinitis and inferior turbinate hypertrophy not responsive to medical therapy who underwent endoscopic submucosal diathermy (ESMD) (14 patients) or endoscopic submucosal resection (ESMR) (15 patients) with intraoperative and 3-6 months postoperative inferior turbinate biopsies, were included in the study. Epithelial and mucosal architecture was compared between the two groups. RESULTS: Both groups showed a significant decrease in epithelial denudation (p < 0.001), reversal of basement membrane thickening (p < 0.001) and increase in density of cilia (p < 0.001). The degree of improvement in histological characteristics between ESMD and ESMR groups was not significant. CONCLUSIONS: Surgical intervention for inferior turbinate hypertrophy by both ESMD and ESMR results in significant restoration of nasal mucosal epithelium in patients with allergic rhinitis as early as 3-month postoperatively. There was, however, no significant difference in the histological changes between those who underwent ESMD and ESMR. CLINICAL TRIALS OF INDIA, REGISTRY NUMBER: CTRI/2015/01/005373.
PURPOSE: Consensus has not been reached regarding the optimal reduction procedure for inferior turbinate hypertrophy in allergic rhinitis and whether such procedures result in improvement in mucosal architecture. METHODS: Twenty-nine patients aged 18-45 years (mean 26.8 years), with allergic rhinitis and inferior turbinate hypertrophy not responsive to medical therapy who underwent endoscopic submucosal diathermy (ESMD) (14 patients) or endoscopic submucosal resection (ESMR) (15 patients) with intraoperative and 3-6 months postoperative inferior turbinate biopsies, were included in the study. Epithelial and mucosal architecture was compared between the two groups. RESULTS: Both groups showed a significant decrease in epithelial denudation (p < 0.001), reversal of basement membrane thickening (p < 0.001) and increase in density of cilia (p < 0.001). The degree of improvement in histological characteristics between ESMD and ESMR groups was not significant. CONCLUSIONS: Surgical intervention for inferior turbinate hypertrophy by both ESMD and ESMR results in significant restoration of nasal mucosal epithelium in patients with allergic rhinitis as early as 3-month postoperatively. There was, however, no significant difference in the histological changes between those who underwent ESMD and ESMR. CLINICAL TRIALS OF INDIA, REGISTRY NUMBER: CTRI/2015/01/005373.
Authors: Claus Bachert; Ruby Pawankar; Luo Zhang; Chaweewan Bunnag; Wytske J Fokkens; Daniel L Hamilos; Orathai Jirapongsananuruk; Robert Kern; Eli O Meltzer; Joaquim Mullol; Robert Naclerio; Renata Pilan; Chae-Seo Rhee; Harumi Suzaki; Richard Voegels; Michael Blaiss Journal: World Allergy Organ J Date: 2014-10-27 Impact factor: 4.084
Authors: João Pedro T Garcia; Bianca H de Moura; Vinícius H Rodrigues; Manoela A Vivan; Simone M de Azevedo; José Eduardo L Dolci; Raphaella Migliavacca; Michelle Lavinsky-Wolff Journal: Int Arch Otorhinolaryngol Date: 2021-08-05