Hee Suk Jung1, Jin Gu Lee2, Chang Young Lee2, Dae Joon Kim2, Kyung Young Chung2. 1. Department of Thoracic and Cardiovascular Surgery, CHA Bundang Medical Center, CHA University, Seoul, Korea. 2. Department of Thoracic and Cardiovascular Surgery, Yonsei University, College of Medicine, Seoul, Korea.
Abstract
BACKGROUND: To validate new proposals for the revision of T descriptors and to compare the prognostic value of the seventh and forthcoming eighth edition of the tumor, node and metastasis (TNM) classification for lung cancer. METHODS: A retrospective analysis was conducted of 1,316 patients with non-small lung cancer who underwent pulmonary resection between 1999 and 2012. Patients who had a positive nodal status or distant metastasis were excluded. We classified these patients according to the seventh and eighth edition of the TNM system, and analyzed differences in stage specific survival. Harrell's concordance (C)-index and Heagerty's integrated area under the curve (iAUC) were used to assess the overall predictive ability of the different TNM versions. RESULTS: There were no significant survival differences between each stage based on the T stage criteria of the eighth edition, most notably between T1a and T1b (P=0.752), and T1c, T2a, and T2b (P=0.832). The C-indices of the classification based on the seventh and eighth edition were 0.681 and 0.675, respectively. There was no significant difference in the C-indices between the seventh and eighth edition. The iAUC value for overall survival of the seventh and eighth staging editions was 0.637 and 0.631, respectively. The differences in iAUC between the seventh and eighth editions were also not statistically significant. CONCLUSIONS: The newly proposed T descriptors in the eighth TNM classification system did not allow a more accurate prediction of prognosis compared with the current seventh edition in our population.
BACKGROUND: To validate new proposals for the revision of T descriptors and to compare the prognostic value of the seventh and forthcoming eighth edition of the tumor, node and metastasis (TNM) classification for lung cancer. METHODS: A retrospective analysis was conducted of 1,316 patients with non-small lung cancer who underwent pulmonary resection between 1999 and 2012. Patients who had a positive nodal status or distant metastasis were excluded. We classified these patients according to the seventh and eighth edition of the TNM system, and analyzed differences in stage specific survival. Harrell's concordance (C)-index and Heagerty's integrated area under the curve (iAUC) were used to assess the overall predictive ability of the different TNM versions. RESULTS: There were no significant survival differences between each stage based on the T stage criteria of the eighth edition, most notably between T1a and T1b (P=0.752), and T1c, T2a, and T2b (P=0.832). The C-indices of the classification based on the seventh and eighth edition were 0.681 and 0.675, respectively. There was no significant difference in the C-indices between the seventh and eighth edition. The iAUC value for overall survival of the seventh and eighth staging editions was 0.637 and 0.631, respectively. The differences in iAUC between the seventh and eighth editions were also not statistically significant. CONCLUSIONS: The newly proposed T descriptors in the eighth TNM classification system did not allow a more accurate prediction of prognosis compared with the current seventh edition in our population.
Authors: Ramón Rami-Porta; Vanessa Bolejack; John Crowley; David Ball; Jhingook Kim; Gustavo Lyons; Thomas Rice; Kenji Suzuki; Charles F Thomas; William D Travis; Yi-Long Wu Journal: J Thorac Oncol Date: 2015-07 Impact factor: 15.609
Authors: Ramón Rami-Porta; David Ball; John Crowley; Dorothy J Giroux; James Jett; William D Travis; Masahiro Tsuboi; Eric Vallières; Peter Goldstraw Journal: J Thorac Oncol Date: 2007-07 Impact factor: 15.609
Authors: José-María Matilla; M Zabaleta; E Martínez-Téllez; J Abal; A Rodríguez-Fuster; J Hernández-Hernández Journal: J Clin Transl Res Date: 2020-09-02