| Literature DB >> 29599895 |
Xian Wen Tan1,2, Mrinal Bhave3, Alan Yean Yip Fong4,5, Eiji Matsuura6,7, Kazuko Kobayashi6,7, Lian Hua Shen6,7, Siaw San Hwang1,2.
Abstract
[This corrects the article DOI: 10.1155/2016/6943053.].Entities:
Year: 2018 PMID: 29599895 PMCID: PMC5828281 DOI: 10.1155/2018/3136860
Source DB: PubMed Journal: Oxid Med Cell Longev ISSN: 1942-0994 Impact factor: 6.543
The relative inhibitory concentration (IC50) of RBE of BJLN and MR219. Data presented as mean ± standard deviation of three technical replicates (n = 3).
| BJLN | MR219 | |||
|---|---|---|---|---|
| Log (dose) | Dose | Log (dose) | Dose | |
| Day 1 | 1.808 ± 0.011 | 64.27 | 1.980 ± 0.013 | 95.56 |
| Day 2 | 1.775 ± 0.002 | 59.57 | 2.047 ± 0.026 | 111.40 |
| Day 3 | 1.800 ± 0.004 | 63.10 | 2.033 ± 0.029 | 108.00 |
Average IC50 of H2O2 for H9c2(2-1) cells. The IC50 value was determined from respective cell viability curves ( Figure 5) via GraphPad Prism (GraphPad Software Inc., USA). Data represent mean ± standard deviation of 3 (n = 3). ∗ denotes significantly different from negative control treated with media + 1% EtOH at P ≤ 0.05. Graphical representations of data were depicted in Figure 5.
| Average IC50 of H2O2 ( | ||
|---|---|---|
| Log [H2O2] | H2O2 | |
| Control sample | ||
| Negative control (media + 1% EtOH) | 2.433 ± 0.040 | 271.00 |
| RBE | ||
| BJLN (25 | 2.776 ± 0.028∗ | 597.20 |
| BJLN (50 | 1.954 ± 0.033∗ | 89.95 |
| MR219 (50 | 2.561 ± 0.035∗ | 364.20 |
| MR219 (100 | 2.158 ± 0.032∗ | 143.90 |
Figure 3Total contents of selected bioactive compounds in the RBE. Different letters on a bar represent significant differences at P ≤ 0.05 (Tukey's test).
Figure 5Effects of H2O2 inductions on cell viabilities of H9c2(2-1) cardiomyocytes pretreated with different concentrations of (a) BJLN RBE (25 μg/mL and 50 μg/mL) and (b) MR219 RBE (50 μg/mL and 100 μg/mL).