| Literature DB >> 29599521 |
Claude-Alexandre Gustave1,2, Anne Tristan1,2, Patricia Martins-Simões1,2, Marc Stegger3, Yvonne Benito1,2, Paal Skytt Andersen3,4, Michèle Bes1,2, Typhanie Le Hir1,2, Binh An Diep5, Anne-Catrin Uhlemann6, Philippe Glaser7, Frédéric Laurent1,2, Thierry Wirth8,9, François Vandenesch10,11.
Abstract
Community-acquired (CA)- as opposed to hospital acquired- methicillin-resistant Staphylococcus aureus (MRSA) lineages arose worldwide during the 1990s. To determine which factors, including selective antibiotic pressure, govern the expansion of two major lineages of CA-MRSA, namely "USA300" in Northern America and "European ST80" in North Africa, Europe and Middle-East, we explored virulence factor expression, and fitness levels with or without antibiotics. The sampled strains were collected in a temporal window representing various steps of the epidemics, reflecting predicted changes in effective population size as inferred from whole-genome analysis. In addition to slight variations in virulence factor expression and biofilm production that might influence the ecological niches of theses lineages, competitive fitness experiments revealed that the biological cost of resistance to methicillin, fusidic acid and fluoroquinolones is totally reversed in the presence of trace amount of antibiotics. Our results suggest that low-level antibiotics exposure in human and animal environments contributed to the expansion of both European ST80 and USA300 lineages in community settings. This surge was likely driven by antibiotic (ab)use promoting the accumulation of antibiotics as environmental pollutants. The current results provide a novel link between effective population size increase of a pathogen and a selective advantage conferred by antibiotic resistance.Entities:
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Year: 2018 PMID： 29599521 PMCID： PMC6052156 DOI： 10.1038/s41396-018-0110-4
Source DB: PubMed Journal: ISME J ISSN： 1751-7362 Impact factor: 10.302