Literature DB >> 29599277

Preclinical Studies of Stem Cell Therapy for Heart Disease.

Bryon A Tompkins1, Wayne Balkan1, Johannes Winkler1, Mariann Gyöngyösi1, Georg Goliasch1, Francisco Fernández-Avilés1, Joshua M Hare2.   

Abstract

As part of the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the role of preclinical studies designed to advance stem cell therapies for cardiovascular disease. The quality of this research has improved over the past 10 to 15 years and overall indicates that cell therapy promotes cardiac repair. However, many issues remain, including inability to provide complete cardiac recovery. Recent studies question the need for intact cells suggesting that harnessing what the cells release is the solution. Our contribution describes important breakthroughs and current directions in a cell-based approach to alleviating cardiovascular disease.
© 2018 American Heart Association, Inc.

Entities:  

Keywords:  heart failure; infarction; regenerative medicine; stem cells

Mesh：

Year:  2018        PMID： 29599277      PMCID： PMC7340290          DOI： 10.1161/CIRCRESAHA.117.312486

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  153 in total

1.  Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.

Authors:  Massimiliano Gnecchi; Huamei He; Olin D Liang; Luis G Melo; Fulvio Morello; Hui Mu; Nicolas Noiseux; Lunan Zhang; Richard E Pratt; Joanne S Ingwall; Victor J Dzau
Journal:  Nat Med       Date:  2005-04       Impact factor: 53.440

2.  Enhancement of angiogenesis by the implantation of self bone marrow cells in a rat ischemic heart model.

Authors:  T Kobayashi; K Hamano; T S Li; T Katoh; S Kobayashi; M Matsuzaki; K Esato
Journal:  J Surg Res       Date:  2000-04       Impact factor: 2.192

Review 3.  Diagnostic and prognostic value of 3D NOGA mapping in ischemic heart disease.

Authors:  Mariann Gyöngyösi; Nabil Dib
Journal:  Nat Rev Cardiol       Date:  2011-05-17       Impact factor: 32.419

4.  Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia.

Authors:  S Fuchs; R Baffour; Y F Zhou; M Shou; A Pierre; F O Tio; N J Weissman; M B Leon; S E Epstein; R Kornowski
Journal:  J Am Coll Cardiol       Date:  2001-05       Impact factor: 24.094

5.  Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium.

Authors:  Yao Liang Tang; Qiang Zhao; Y Clare Zhang; Leilei Cheng; Mingya Liu; Jianhui Shi; Yin Zeng Yang; Chuizhen Pan; Junbo Ge; M Ian Phillips
Journal:  Regul Pept       Date:  2004-01-15

6.  Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.

Authors:  T Takahashi; C Kalka; H Masuda; D Chen; M Silver; M Kearney; M Magner; J M Isner; T Asahara
Journal:  Nat Med       Date:  1999-04       Impact factor: 53.440

7.  Cardiac Stem Cell Hybrids Enhance Myocardial Repair.

Authors:  Pearl Quijada; Hazel T Salunga; Nirmala Hariharan; Jonathan D Cubillo; Farid G El-Sayed; Maryam Moshref; Kristin M Bala; Jacqueline M Emathinger; Andrea De La Torre; Lucia Ormachea; Roberto Alvarez; Natalie A Gude; Mark A Sussman
Journal:  Circ Res       Date:  2015-07-30       Impact factor: 17.367

Review 8.  Rebuilding the Damaged Heart: Mesenchymal Stem Cells, Cell-Based Therapy, and Engineered Heart Tissue.

Authors:  Samuel Golpanian; Ariel Wolf; Konstantinos E Hatzistergos; Joshua M Hare
Journal:  Physiol Rev       Date:  2016-07       Impact factor: 37.312

9.  Human Wharton's Jelly-Derived Stem Cells Display a Distinct Immunomodulatory and Proregenerative Transcriptional Signature Compared to Bone Marrow-Derived Stem Cells.

Authors:  Raf Donders; Jeroen F J Bogie; Stylianos Ravanidis; Pascal Gervois; Marjan Vanheusden; Raphaël Marée; Marie Schrynemackers; Hubert J M Smeets; Jef Pinxteren; Kristel Gijbels; Sara Walbers; Robert W Mays; Robert Deans; Ludo Van Den Bosch; Piet Stinissen; Ivo Lambrichts; Wilfried Gyselaers; Niels Hellings
Journal:  Stem Cells Dev       Date:  2017-12-21       Impact factor: 3.272

10.  A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling.

Authors:  David Simpson; Hong Liu; Tai-Hwang Michael Fan; Robert Nerem; Samuel C Dudley
Journal:  Stem Cells       Date:  2007-05-24       Impact factor: 6.277
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  34 in total

1.  Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs.

Authors:  Teng Su; Ke Huang; Kyle G Mathews; Valery F Scharf; Shiqi Hu; Zhenhua Li; Brianna N Frame; Jhon Cores; Phuong-Uyen Dinh; Michael A Daniele; Frances S Ligler; Ke Cheng
Journal:  ACS Biomater Sci Eng       Date:  2020-10-05

2.  Inflammation in myocardial injury: mesenchymal stem cells as potential immunomodulators.

Authors:  Weiang Yan; Ejlal Abu-El-Rub; Sekaran Saravanan; Lorrie A Kirshenbaum; Rakesh C Arora; Sanjiv Dhingra
Journal:  Am J Physiol Heart Circ Physiol       Date:  2019-05-24       Impact factor: 4.733

3.  N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts.

Authors:  Xi Lou; Meng Zhao; Chengming Fan; Vladimir G Fast; Mani T Valarmathi; Wuqiang Zhu; Jianyi Zhang
Journal:  Cardiovasc Res       Date:  2020-03-01       Impact factor: 10.787

4.  c-kit+VEGFR-2+ Mesenchymal Stem Cells Differentiate into Cardiovascular Cells and Repair Infarcted Myocardium after Transplantation.

Authors:  Pei Zhou; Shu-Na Yu; Hai-Feng Zhang; Yong-Li Wang; Ping Tao; Yu-Zhen Tan; Hai-Jie Wang
Journal:  Stem Cell Rev Rep       Date:  2022-08-13       Impact factor: 6.692

5.  An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.

Authors:  Ke Huang; Emily W Ozpinar; Teng Su; Junnan Tang; Deliang Shen; Li Qiao; Shiqi Hu; Zhenhua Li; Hongxia Liang; Kyle Mathews; Valery Scharf; Donald O Freytes; Ke Cheng
Journal:  Sci Transl Med       Date:  2020-04-08       Impact factor: 17.956

6.  Volumetric Optoacoustic Tomography Differentiates Myocardial Remodelling.

Authors:  Moritz Wildgruber; Daniel Razansky; Ivana Ivankovic; Xosé Luís Déan-Ben; Helena Haas; Melanie A Kimm
Journal:  Mol Imaging Biol       Date:  2020-10       Impact factor: 3.488

7.  Cardiac Cell Therapy Rejuvenates the Infarcted Rodent Heart via Direct Injection but Not by Vascular Infusion.

Authors:  Ronald J Vagnozzi; Michelle A Sargent; Jeffery D Molkentin
Journal:  Circulation       Date:  2020-03-23       Impact factor: 29.690

8.  Echocardiography-guided percutaneous left ventricular intracavitary injection as a cell delivery approach in infarcted mice.

Authors:  Yibing Nong; Yiru Guo; Alex Tomlin; Xiaoping Zhu; Marcin Wysoczynski; Qianhong Li; Roberto Bolli
Journal:  Mol Cell Biochem       Date:  2021-02-05       Impact factor: 3.396

9.  A Swine Hind Limb Ischemia Model Useful for Testing Peripheral Artery Disease Therapeutics.

Authors:  Juline N Deppen; Sydney C Ginn; Na Hee Kim; Lanfang Wang; Ronald J Voll; Steven H Liang; Mark M Goodman; John N Oshinski; Rebecca D Levit
Journal:  J Cardiovasc Transl Res       Date:  2021-05-28       Impact factor: 4.132

Review 10.  Cardiac Progenitor Cells.

Authors:  Shaimaa Shouman; Amr Zaher; Alaa Abdelhameed; Sara Elshaboury; Samar Sakr; Bahaa Eldin Fouda; Haya Mohamed; Nagwa El-Badri
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622
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