| Literature DB >> 29599242 |
Jamie Voyles1, Douglas C Woodhams2,3, Veronica Saenz4, Allison Q Byrne5, Rachel Perez6, Gabriela Rios-Sotelo7, Mason J Ryan7,8, Molly C Bletz2, Florence Ann Sobell9, Shawna McLetchie9, Laura Reinert9, Erica Bree Rosenblum5, Louise A Rollins-Smith9, Roberto Ibáñez3,10, Julie M Ray11, Edgardo J Griffith12, Heidi Ross3, Corinne L Richards-Zawacki3,4.
Abstract
Infectious diseases rarely end in extinction. Yet the mechanisms that explain how epidemics subside are difficult to pinpoint. We investigated host-pathogen interactions after the emergence of a lethal fungal pathogen in a tropical amphibian assemblage. Some amphibian host species are recovering, but the pathogen is still present and is as pathogenic today as it was almost a decade ago. In addition, some species have defenses that are more effective now than they were before the epidemic. These results suggest that host recoveries are not caused by pathogen attenuation and may be due to shifts in host responses. Our findings provide insights into the mechanisms underlying disease transitions, which are increasingly important to understand in an era of emerging infectious diseases and unprecedented global pandemics.Entities:
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Year: 2018 PMID: 29599242 DOI: 10.1126/science.aao4806
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728