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Literature DB >> 29597140

Presynaptic origins of distinct modes of neurotransmitter release.

Abstract

Presynaptic nerve terminals release neurotransmitter synchronously, asynchronously or spontaneously. During synchronous neurotransmission release is precisely coupled to action potentials, in contrast, asynchronous release events show only loose temporal coupling to presynaptic activity whereas spontaneous neurotransmission occurs independent of presynaptic activity. The mechanisms that give rise to this diversity in neurotransmitter release modes are poorly understood. Recent studies have described several presynaptic molecular pathways controlling synaptic vesicle pool segregation and recycling, which in turn may dictate distinct modes of neurotransmitter release. In this article, we review this recent work regarding neurotransmitter release modes and their relationship to synaptic vesicle pool dynamics as well as the molecular machinery that establishes synaptic vesicle pool identity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Neurotransmitter Agents

Year: 2018 PMID： 29597140 PMCID： PMC6066415 DOI： 10.1016/j.conb.2018.03.005

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

108 in total

1. Independent vesicle pools underlie different modes of release during neuronal development.

Authors: Laura C Andreae; Naila Ben Fredj; Juan Burrone
Journal: J Neurosci Date: 2012-02-01 Impact factor: 6.167

2. v-SNARE composition distinguishes synaptic vesicle pools.

Authors: Zhaolin Hua; Sergio Leal-Ortiz; Sarah M Foss; Clarissa L Waites; Craig C Garner; Susan M Voglmaier; Robert H Edwards
Journal: Neuron Date: 2011-08-11 Impact factor: 17.173

Review 3. Structure and function of longin SNAREs.

Authors: Frédéric Daste; Thierry Galli; David Tareste
Journal: J Cell Sci Date: 2015-11-13 Impact factor: 5.285

Review 4. Exocytosis and endocytosis: modes, functions, and coupling mechanisms.

Authors: Ling-Gang Wu; Edaeni Hamid; Wonchul Shin; Hsueh-Cheng Chiang
Journal: Annu Rev Physiol Date: 2013-11-20 Impact factor: 19.318

5. Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling.

Authors: Catherine R Wasser; Mert Ertunc; Xinran Liu; Ege T Kavalali
Journal: J Physiol Date: 2006-12-14 Impact factor: 5.182

6. Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.

Authors: Yildirim Sara; Manjot Bal; Megumi Adachi; Lisa M Monteggia; Ege T Kavalali
Journal: J Neurosci Date: 2011-04-06 Impact factor: 6.167

7. Synaptic vesicle pool-specific modification of neurotransmitter release by intravesicular free radical generation.

Authors: Olusoji A T Afuwape; Catherine R Wasser; Thomas Schikorski; Ege T Kavalali
Journal: J Physiol Date: 2016-12-02 Impact factor: 5.182

8. Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.

Authors: Cole W Graydon; Soyoun Cho; Geng-Lin Li; Bechara Kachar; Henrique von Gersdorff
Journal: J Neurosci Date: 2011-11-16 Impact factor: 6.167

9. Acute suppression of spontaneous neurotransmission drives synaptic potentiation.

Authors: Elena Nosyreva; Kristen Szabla; Anita E Autry; Alexey G Ryazanov; Lisa M Monteggia; Ege T Kavalali
Journal: J Neurosci Date: 2013-04-17 Impact factor: 6.167

10. Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.

Authors: Seong Joo Koo; Gaga Kochlamazashvili; Benjamin Rost; Dmytro Puchkov; Niclas Gimber; Martin Lehmann; Georgi Tadeus; Jan Schmoranzer; Christian Rosenmund; Volker Haucke; Tanja Maritzen
Journal: Neuron Date: 2015-09-24 Impact factor: 17.173

28 in total

1. Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.

Authors: Susana Restrepo; Nora J Langer; Kylan A Nelson; Jason Aoto
Journal: J Neurosci Date: 2019-10-02 Impact factor: 6.167

Presynaptic origins of distinct modes of neurotransmitter release.

1. Independent vesicle pools underlie different modes of release during neuronal development.

2. v-SNARE composition distinguishes synaptic vesicle pools.

Review 3. Structure and function of longin SNAREs.

Review 4. Exocytosis and endocytosis: modes, functions, and coupling mechanisms.

5. Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling.

6. Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.

7. Synaptic vesicle pool-specific modification of neurotransmitter release by intravesicular free radical generation.

8. Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.

9. Acute suppression of spontaneous neurotransmission drives synaptic potentiation.

10. Vesicular Synaptobrevin/VAMP2 Levels Guarded by AP180 Control Efficient Neurotransmission.

1. Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.

Review 2. The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms.

3. Spike Activity Regulates Vesicle Filling at a Glutamatergic Synapse.

4. Activity-evoked and spontaneous opening of synaptic fusion pores.

5. Neurexins cluster Ca²⁺ channels within the presynaptic active zone.

6. 5-HT₃R-sourced calcium enhances glutamate release from a distinct vesicle pool.

7. Search for a minimal machinery for Ca²⁺-triggered millisecond neuroexocytosis.

8. Developmental Synaptic Changes at the Transient Olivocochlear-Inner Hair Cell Synapse.

9. Behavioral Analysis of SNAP-25 and Synaptobrevin-2 Haploinsufficiency in Mice.

10. The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores.