Patrick Omoumi1,2,3, Hugo Babel3, Brigitte M Jolles3,4, Julien Favre3. 1. 1 Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire and University of Lausanne , Lausanne , Switzerland. 2. 2 Department of Radiology, Cliniques Universitaires St Luc - UC Louvain , Brussels , Belgium. 3. 3 Department of Musculoskeletal Medicine, Swiss BioMotion Lab, Centre Hospitalier Universitaire Vaudois and University of Lausanne , Lausanne , Switzerland. 4. 4 Institute of Microengineering, Ecole Polytechnique Fédérale de Lausanne , Lausanne , Switzerland.
Abstract
OBJECTIVE: To test, through tridimensional analysis, whether (1) cartilage thickness at the posterior aspect of femoral condyles differs in knees with medial femorotibial osteoarthritis (OA) compared to non-OA knees; (2) the location of the thickest cartilage at the posterior aspect of femoral condyles differs between OA and non-OA knees. METHODS: CT arthrograms of knees without radiographic OA (n = 30) and with severe medial femorotibial OA (n = 30) were selected retrospectively from patients over 50 years of age. The groups did not differ in gender, age and femoral size. CT arthrograms were segmented to measure the mean cartilage thickness, the maximal cartilage thickness and its location in a region of interest at the posterior aspect of condyles. RESULTS: For the medial condyle, mean and maximum cartilage thicknesses were statistically significantly higher in OA knees compared to non-OA knees [1.66 vs 1.46 mm (p = 0.03) and 2.56 vs 2.14 mm (p = 0.003), respectively]. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle for both groups, without significant difference between groups. For the lateral condyle, no statistically significant difference between non-OA and OA knees was found (p ≥ 0.17). CONCLUSION: Cartilage at the posterior aspect of the medial condyle, but not the lateral condyle, is statistically significantly thicker in advanced medial femorotibial OA knees compared to non-OA knees. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage. Advances in knowledge: This study, through a quantitative tridimensional approach, shows that cartilage at the posterior aspect of the medial condyles is thicker in severe femorotibial osteoarthritic knees compared to non-OA knees. In the posterior aspect of the medial condyle, the thickest cartilage is located in the vicinity of the center of the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage.
OBJECTIVE: To test, through tridimensional analysis, whether (1) cartilage thickness at the posterior aspect of femoral condyles differs in knees with medial femorotibial osteoarthritis (OA) compared to non-OA knees; (2) the location of the thickest cartilage at the posterior aspect of femoral condyles differs between OA and non-OA knees. METHODS: CT arthrograms of knees without radiographic OA (n = 30) and with severe medial femorotibial OA (n = 30) were selected retrospectively from patients over 50 years of age. The groups did not differ in gender, age and femoral size. CT arthrograms were segmented to measure the mean cartilage thickness, the maximal cartilage thickness and its location in a region of interest at the posterior aspect of condyles. RESULTS: For the medial condyle, mean and maximum cartilage thicknesses were statistically significantly higher in OA knees compared to non-OA knees [1.66 vs 1.46 mm (p = 0.03) and 2.56 vs 2.14 mm (p = 0.003), respectively]. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle for both groups, without significant difference between groups. For the lateral condyle, no statistically significant difference between non-OA and OA knees was found (p ≥ 0.17). CONCLUSION:Cartilage at the posterior aspect of the medial condyle, but not the lateral condyle, is statistically significantly thicker in advanced medial femorotibial OA knees compared to non-OA knees. The thickest cartilage was located in the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage. Advances in knowledge: This study, through a quantitative tridimensional approach, shows that cartilage at the posterior aspect of the medial condyles is thicker in severe femorotibial osteoarthritic knees compared to non-OA knees. In the posterior aspect of the medial condyle, the thickest cartilage is located in the vicinity of the center of the half most medial aspect of the posterior medial condyle. These results will serve as the basis for future research to determine the histobiological processes involved in this thicker cartilage.
Authors: E Calvo; I Palacios; E Delgado; J Ruiz-Cabello; P Hernández; O Sánchez-Pernaute; J Egido; G Herrero-Beaumont Journal: Osteoarthritis Cartilage Date: 2001-07 Impact factor: 6.576
Authors: Wolfgang Wirth; Olivier Benichou; C Kent Kwoh; Ali Guermazi; David Hunter; Reinhard Putz; Felix Eckstein Journal: Magn Reson Med Date: 2010-03 Impact factor: 4.668
Authors: Julien Favre; Jennifer C Erhart-Hledik; Katerina Blazek; Benedikt Fasel; Garry E Gold; Thomas P Andriacchi Journal: J Orthop Res Date: 2017-05-02 Impact factor: 3.494
Authors: D J Hunter; J B Niu; Y Zhang; M LaValley; C E McLennan; M Hudelmaier; F Eckstein; D T Felson Journal: Ann Rheum Dis Date: 2008-01-24 Impact factor: 19.103