| Literature DB >> 29594985 |
Olivier Simon1, Blandine Acket2, Carole Forfait3, Dominique Girault4, Ann-Claire Gourinat5, Pauline Millon6, Maguy Daures3, Jessica Vanhomwegen7, Segolene Billot6, Antoine Biron5, Damien Hoinard7, Elodie Descloux8, David Guyon6, Jean Claude Manuguerra7, Sylvie Laumond3, Nicolas Molko6, Myrielle Dupont-Rouzeyrol4.
Abstract
Zika virus (ZIKV) infection has been associated with neurologic disorders including Guillain-Barré syndrome (GBS). In New Caledonia during the ZIKV outbreak (2014-2015), case-control and retrospective studies have been performed to assess the link between ZIKV and GBS. Among the 15 cases included, 33% had evidence of a recent ZIKV infection compared to only 3.3% in the 30 controls involved. All patients were Melanesian, had facial diplegia and similar neurophysiological pattern consistent with acute inflammatory demyelinating polyneuropathy, and recovered well. Furthermore, during the peak of ZIKV transmission, we observed a number of GBS cases higher than the calculated upper limit, emphasizing the fact that ZIKV is now a major trigger of GBS.Entities:
Keywords: Case control study; Guillain-Barré syndrome; New Caledonia; Zika virus
Mesh：
Year: 2018 PMID： 29594985 DOI： 10.1007/s13365-018-0621-9
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643