| Literature DB >> 2959449 |
D J Back1, S F Grimmer, N Shenoy, M L Orme.
Abstract
The plasma concentrations of 3-keto-desogestrel have been measured by radioimmunoassay in a crossover study in nine healthy female volunteers given oral desogestrel (150 micrograms) and ethinyloestradiol (30 micrograms) and intravenous (i.v.) 3-keto-desogestrel (150 micrograms) and ethinyloestradiol (30 micrograms). Bioavailability ranged between 40.0 and 113% with a mean value ( +/- SD) of 76.1 +/- 22.5%. Only 3 subjects had a bioavailability of less than 70%. There was no significant difference in the elimination half life of 3-keto-desogestrel which was 12.6 +/- 4.1h following i.v. administration and 11.9 +/- 4.1h after oral administration of desogestrel.Entities:
Keywords: Biology; Clinical Research; Contraception; Contraceptive Agents, Female; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Methods; Developed Countries; Economic Factors; Endocrine System; England; Europe; Family Planning; Hemic System; Hormones; Northern Europe; Oral Contraceptives; Physiology; Reproductive Control Agents; Research And Development; Research Methodology; Technology; United Kingdom
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Year: 1987 PMID： 2959449 DOI： 10.1016/s0010-7824(87)80021-5
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375