Matrix assisted laser desorption/ionization time-of-flight mass spectrometric determination of benzo[a]pyrene using a MIL-101(Fe) matrix.

A method is described for the matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF)-based determination of benzo[a]pyrene (BaP) by using the metal-organic framework MIL-101(Fe) as a matrix. Following optimization of the experimental parameters, the method has a detection limit as low as 0.1 μg·L-1, which makes it more sensitive than previous methods for BaP analysis, and its analysis time is only 1 min. Its applicability was evaluated by analyzing sesame oil, linseed oil, camellia seed oil, and olive oil spiked with BaP at three levels (10, 1, and 0.5 μg·kg-1), and the recovery range was found to range from 80.0 to 114.8% with relative standard deviations (RSDs) between 3.9 and 13.7%. Graphical abstract The metal-organic framework MIL-101(Fe) was applied as a new matrix to the quantitative detection of benzo[a]pyrene (BaP) by matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF).