Weiguo Wang1, Nianfei Zhang2, Wanshou Guo1, Fuqiang Gao1. 1. Department of Orthopaedic Surgery, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, People's Republic of China. 2. Department of Orthopaedic Surgery, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, People's Republic of China. zhangnianfei@hotmail.com.
Abstract
PURPOSE: The purpose of this study was to retrospectively analyze the clinical, functional, and radiological outcomes of combined pharmacotherapy to ONFH after high-dose corticosteroid therapy. METHOD: From August 2003 to June 2015, five patients (ten hips) of ONFH in ARCO stage I, after SARS and Interstitial pneumonia, were treated by combined pharmacotherapy. Lipo-prostaglandin E1 10 μg iv Bid × 28 days, enoxaparin 6000 iu H QD × 12 weeks, alendronate sodium tablet 10 mg QD × 1 year. The patients were fully weight-bearing following completion of the follow-up. RESULT: For these five patients (ten hips), Harris score was 100 from the diagnosis to final follow-up time. Radiologic findings show no signs of collapse, necrotic focus was repaired, and ARCO stages were changed from IC into IIB. CONCLUSION: This combined pharmacotherapy has promising treatment results for delaying or preventing collapse of ONFH in ARCO stage I.
PURPOSE: The purpose of this study was to retrospectively analyze the clinical, functional, and radiological outcomes of combined pharmacotherapy to ONFH after high-dose corticosteroid therapy. METHOD: From August 2003 to June 2015, five patients (ten hips) of ONFH in ARCO stage I, after SARS and Interstitial pneumonia, were treated by combined pharmacotherapy. Lipo-prostaglandin E1 10 μg iv Bid × 28 days, enoxaparin 6000 iu H QD × 12 weeks, alendronate sodium tablet 10 mg QD × 1 year. The patients were fully weight-bearing following completion of the follow-up. RESULT: For these five patients (ten hips), Harris score was 100 from the diagnosis to final follow-up time. Radiologic findings show no signs of collapse, necrotic focus was repaired, and ARCO stages were changed from IC into IIB. CONCLUSION: This combined pharmacotherapy has promising treatment results for delaying or preventing collapse of ONFH in ARCO stage I.
Entities:
Keywords:
Collapse; Osteonecrosis of the femoral head; Pharmacotherapy; Porous media; Subchondral plate
Authors: Philippe Hernigou; Benjamin Thiebaut; Victor Housset; Claire Bastard; Yasuhiro Homma; Younes Chaib; Charles Henri Flouzat Lachaniette Journal: Int Orthop Date: 2018-04-26 Impact factor: 3.075