Literature DB >> 2959284

The specificity of the human IGF-2 receptor.

M Tally1, G Enberg, C H Li, K Hall.   

Abstract

The specificity of the type 2 insulinlike growth factor (IGF) receptor is evaluated in human placenta membranes and the human cell line K562. K562 cells have type 2 but not type 1 IGF receptors. Native IGF-2 isolated from human plasma and synthetic IGF-2 were equipotent in competing with labeled IGF-2 in both systems. Pure IGF-1 isolated from plasma, synthetic IGF-1 and recombinant IGF-1 could not crossreact with the type 2 IGF receptor in concentrations up to 1 microgram/ml in both systems. Studies on placenta membrane were done in the presence of 300 ug/ml insulin to block the type 1 IGF receptors. It is concluded that IGF-1, as well as insulin, cannot crossreact with the human type 2 IGF receptor.

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Year:  1987        PMID： 2959284     DOI： 10.1016/s0006-291x(87)80198-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

Review 1.  Interactions of pro-cathepsin D and IGF-II on the mannose-6-phosphate/IGF-II receptor.

Authors:  F Vignon; H Rochefort
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

2.  Partial purification of an IGF-II receptor/binding protein from the erythroleukemia cell line K562.

Authors:  Q Zhang; K Hall; M Tally
Journal:  Mol Cell Biochem       Date:  1996-01-12       Impact factor: 3.396

3.  Impaired insulin-like growth factor I-mediated stimulation of glucose incorporation into glycogen in vivo in the ob/ob mouse.

Authors:  M A Cascieri; E E Slater; P P Vicario; B G Green; M L Bayne; R Saperstein
Journal:  Diabetologia       Date:  1989-06       Impact factor: 10.122

Review 4.  Autocrine growth factors and solid tumor malignancy.

Authors:  J H Walsh; W E Karnes; F Cuttitta; A Walker
Journal:  West J Med       Date:  1991-08

5.  Regulation of the mannose 6-phosphate/IGF II receptor expression at the cell surface by mannose 6-phosphate, insulin like growth factors and epidermal growth factor.

Authors:  T Braulke; S Tippmer; E Neher; K von Figura
Journal:  EMBO J       Date:  1989-03       Impact factor: 11.598

6.  Insulin-like growth factor II signaling through the insulin-like growth factor II/mannose-6-phosphate receptor promotes exocytosis in insulin-secreting cells.

Authors:  Q Zhang; M Tally; O Larsson; R T Kennedy; L Huang; K Hall; P O Berggren
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

7.  Insulin-like growth factor 2 and short-range stimulatory loops in control of human placental growth.

Authors:  R Ohlsson; L Holmgren; A Glaser; A Szpecht; S Pfeifer-Ohlsson
Journal:  EMBO J       Date:  1989-07       Impact factor: 11.598
  7 in total

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