| Literature DB >> 29590620 |
Rosa van den Berg1, Sander Kooijman2, Raymond Noordam3, Ashna Ramkisoensing4, Gustavo Abreu-Vieira1, Lauren L Tambyrajah1, Wieneke Dijk5, Philip Ruppert5, Isabel M Mol1, Barbara Kramar6, Rosanna Caputo1, Laura Sardón Puig1, Evelien M de Ruiter1, Jan Kroon1, Menno Hoekstra7, Ronald J van der Sluis7, Onno C Meijer1, Ko Willems van Dijk1, Linda W M van Kerkhof8, Constantinos Christodoulides9, Fredrik Karpe9, Zachary Gerhart-Hines6, Sander Kersten5, Johanna H Meijer4, Claudia P Coomans4, Diana van Heemst9, Nienke R Biermasz1, Patrick C N Rensen1.
Abstract
Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity.Entities:
Keywords: APOE(∗)3-Leiden.CETP mice; angiopoietin-like 4; brown adipose tissue; circadian rhythm; diurnal rhythm; fatty acids; lipoprotein lipase; postprandial lipid response; triglycerides
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Year: 2018 PMID： 29590620 DOI： 10.1016/j.celrep.2018.03.004
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423