Literature DB >> 29590065

Beyond PARP-POLθ as an anticancer target.

Geoff S Higgins1, Simon J Boulton2,3.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 29590065     DOI： 10.1126/science.aar5149

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


× No keyword cloud information.
  23 in total

1.  DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.

Authors:  Zi Wang; Yadong Song; Shibo Li; Sunil Kurian; Rong Xiang; Takuya Chiba; Xiaohua Wu
Journal:  J Biol Chem       Date:  2019-01-17       Impact factor: 5.157

2.  Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection.

Authors:  Mu-Yan Cai; Connor E Dunn; Wenxu Chen; Bose S Kochupurakkal; Huy Nguyen; Lisa A Moreau; Geoffrey I Shapiro; Kalindi Parmar; David Kozono; Alan D D'Andrea
Journal:  Cell Rep       Date:  2020-02-18       Impact factor: 9.423

3.  TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks.

Authors:  Julian Lutze; Sara E Warrington; Stephen J Kron
Journal:  Methods Mol Biol       Date:  2022

Review 4.  BRCA1 Mutations in Cancer: Coordinating Deficiencies in Homologous Recombination with Tumorigenesis.

Authors:  John J Krais; Neil Johnson
Journal:  Cancer Res       Date:  2020-08-03       Impact factor: 12.701

Review 5.  Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy.

Authors:  Jeffrey Patterson-Fortin; Alan D D'Andrea
Journal:  Cancer Res       Date:  2020-07-10       Impact factor: 12.701

6.  Mechanistic Insight through Irreversible Inhibition: DNA Polymerase θ Uses a Common Active Site for Polymerase and Lyase Activities.

Authors:  Daniel J Laverty; Ifor P Mortimer; Marc M Greenberg
Journal:  J Am Chem Soc       Date:  2018-07-12       Impact factor: 15.419

7.  Critical DNA damaging pathways in tumorigenesis.

Authors:  Jake A Kloeber; Zhenkun Lou
Journal:  Semin Cancer Biol       Date:  2021-04-24       Impact factor: 15.707

8.  Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.

Authors:  Diana Zatreanu; Helen M R Robinson; Omar Alkhatib; Marie Boursier; Harry Finch; Lerin Geo; Diego Grande; Vera Grinkevich; Robert A Heald; Sophie Langdon; Jayesh Majithiya; Claire McWhirter; Niall M B Martin; Shaun Moore; Joana Neves; Eeson Rajendra; Marco Ranzani; Theresia Schaedler; Martin Stockley; Kimberley Wiggins; Rachel Brough; Sandhya Sridhar; Aditi Gulati; Nan Shao; Luned M Badder; Daniela Novo; Eleanor G Knight; Rebecca Marlow; Syed Haider; Elsa Callen; Graeme Hewitt; Joost Schimmel; Remko Prevo; Christina Alli; Amanda Ferdinand; Cameron Bell; Peter Blencowe; Chris Bot; Mathew Calder; Mark Charles; Jayne Curry; Tennyson Ekwuru; Katherine Ewings; Wojciech Krajewski; Ellen MacDonald; Hollie McCarron; Leon Pang; Chris Pedder; Laurent Rigoreau; Martin Swarbrick; Ed Wheatley; Simon Willis; Ai Ching Wong; Andre Nussenzweig; Marcel Tijsterman; Andrew Tutt; Simon J Boulton; Geoff S Higgins; Stephen J Pettitt; Graeme C M Smith; Christopher J Lord
Journal:  Nat Commun       Date:  2021-06-17       Impact factor: 17.694

9.  Suppression of DNA Polymerase β Activity Is Synthetically Lethal in BRCA1-Deficient Cells.

Authors:  Shelby C Yuhas; Alok Mishra; Theodore L DeWeese; Marc M Greenberg
Journal:  ACS Chem Biol       Date:  2021-07-09       Impact factor: 4.634

10.  A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

Authors:  Jia Zhou; Camille Gelot; Constantia Pantelidou; Adam Li; Hatice Yücel; Rachel E Davis; Anniina Färkkilä; Bose Kochupurakkal; Aleem Syed; Geoffrey I Shapiro; John A Tainer; Brian S J Blagg; Raphael Ceccaldi; Alan D D'Andrea
Journal:  Nat Cancer       Date:  2021-06-17
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.