| Literature DB >> 29590046 |
Liping Zhao1,2, Feng Zhang3, Xiaoying Ding4, Guojun Wu3, Yan Y Lam2, Xuejiao Wang4, Huaqing Fu3, Xinhe Xue3, Chunhua Lu5, Jilin Ma5, Lihua Yu5, Chengmei Xu5, Zhongying Ren5, Ying Xu6, Songmei Xu6, Hongli Shen6, Xiuli Zhu6, Yu Shi7, Qingyun Shen7, Weiping Dong4, Rui Liu3, Yunxia Ling4, Yue Zeng8, Xingpeng Wang8, Qianpeng Zhang3, Jing Wang3, Linghua Wang3, Yanqiu Wu3, Benhua Zeng9, Hong Wei9, Menghui Zhang3, Yongde Peng10, Chenhong Zhang1.
Abstract
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM.Entities:
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Year: 2018 PMID： 29590046 DOI： 10.1126/science.aao5774
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728