Iron-Catalyzed Highly Enantioselective Hydrosilylation of Unactivated Terminal Alkenes.

The iron-catalyzed highly Markovnikov-type selective and enantioselective hydrosilylation of terminal aliphatic alkenes with good functional group tolerance is developed. This operationally simple protocol uses earth-abundant transition metal catalyst, readily available aliphatic alkenes and hydrosilanes to construct valuable chiral organosilanes with better than 99% ee in most cases. The chiral aliphatic alkan-2-ol and chiral dihydroxysilane as an analogue of ketone could be efficiently synthesized via further derivatization of chiral organosilanes without any racemization.