Literature DB >> 29589303

The Colorectal Cancer Microenvironment: Strategies for Studying the Role of Cancer-Associated Fibroblasts.

Rahul Bhome1,2, Massimiliano Mellone1, Katherine Emo1, Gareth J Thomas1, A Emre Sayan1, Alex H Mirnezami3,4.   

Abstract

Colorectal cancer (CRC) is a key public health concern and the second highest cause of cancer related death in Western society. A dynamic interaction exists between CRC cells and the surrounding tumor microenvironment, which can stimulate not only the development of CRC, but its progression and metastasis, as well as the development of resistance to therapy. In this chapter, we focus on the role of fibroblasts within the CRC tumor microenvironment and describe some of the key methods for their study, as well as the evaluation of dynamic interactions within this biological ecosystem.

Entities:  

Keywords:  Cancer-associated fibroblasts; Colorectal cancer; Extracellular vesicles; Tumor microenvironment

Mesh：

Year:  2018        PMID： 29589303      PMCID： PMC5947757          DOI： 10.1007/978-1-4939-7765-9_6

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  9 in total

1.  Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors.

Authors:  Fatima A Haggar; Robin P Boushey
Journal:  Clin Colon Rectal Surg       Date:  2009-11

2.  Colorectal cancer statistics, 2014.

Authors:  Rebecca Siegel; Carol Desantis; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2014-03-17       Impact factor: 508.702

3.  The distribution of secondary growths in cancer of the breast. 1889.

Authors:  S Paget
Journal:  Cancer Metastasis Rev       Date:  1989-08       Impact factor: 9.264

Review 4.  KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.

Authors:  Wendy De Roock; Veerle De Vriendt; Nicola Normanno; Fortunato Ciardiello; Sabine Tejpar
Journal:  Lancet Oncol       Date:  2010-12-14       Impact factor: 41.316

Review 5.  Colorectal cancer heterogeneity and targeted therapy: Clinical implications, challenges and solutions for treatment resistance.

Authors:  Zhenhua Zhai; Xiaohui Yu; Bin Yang; Yunjing Zhang; Long Zhang; Xiaoli Li; Hongzhi Sun
Journal:  Semin Cell Dev Biol       Date:  2016-08-27       Impact factor: 7.727

6.  Profiling the MicroRNA Payload of Exosomes Derived from Ex Vivo Primary Colorectal Fibroblasts.

Authors:  Rahul Bhome; Rebecca Goh; Karen Pickard; Massimiliano Mellone; A Emre Sayan; Alex Mirnezami
Journal:  Methods Mol Biol       Date:  2017

Review 7.  A top-down view of the tumor microenvironment: structure, cells and signaling.

Authors:  Rahul Bhome; Marc D Bullock; Hajir A Al Saihati; Rebecca W Goh; John N Primrose; A Emre Sayan; Alex H Mirnezami
Journal:  Front Cell Dev Biol       Date:  2015-05-29

8.  Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside.

Authors:  R Bhome; H A Al Saihati; R W Goh; M D Bullock; J N Primrose; G J Thomas; A E Sayan; A H Mirnezami
Journal:  New Horiz Transl Med       Date:  2016-01

9.  Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression.

Authors:  M D Bullock; K M Pickard; B S Nielsen; A E Sayan; V Jenei; M Mellone; R Mitter; J N Primrose; G J Thomas; G K Packham; A H Mirenzami; A H Mirnezami
Journal:  Cell Death Dis       Date:  2013-06-20       Impact factor: 8.469
  9 in total
  2 in total

Review 1.  Co-culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques.

Authors:  Ariana E Shannon; Claire E Boos; Amanda B Hummon
Journal:  Proteomics       Date:  2021-02-26       Impact factor: 3.984

2.  Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma.

Authors:  Qiusheng Shan; Kiyofumi Takabatake; Haruka Omori; Hotaka Kawai; May Wathone Oo; Keisuke Nakano; Soichiro Ibaragi; Akira Sasaki; Hitoshi Nagatsuka
Journal:  Int J Oncol       Date:  2021-08-09       Impact factor: 5.650
  2 in total

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