Raluca Cosgarea1,2, Roxana Tristiu3, Raluca Bianca Dumitru4, Nicole Birgit Arweiler5, Simona Rednic4, Cristina Ioana Sirbu6, Liana Lascu3, Anton Sculean7, Sigrun Eick7. 1. Clinic of Periodontology, Philipps University Marburg, Georg-Voigt Str. 3, 35039, Marburg, Germany. ralucacosgarea@gmail.com. 2. Clinic of Prosthodontics, University of Medicine and Pharmacy Iuliu Hatieganu, Str. Clinicilor nr 32, 400006, Cluj-Napoca, Romania. ralucacosgarea@gmail.com. 3. Clinic of Prosthodontics, University of Medicine and Pharmacy Iuliu Hatieganu, Str. Clinicilor nr 32, 400006, Cluj-Napoca, Romania. 4. Clinic of Rheumatology, University of Medicine and Pharmacy Iuliu Hatieganu, Str. Clinicilor nr. 2-4, 400006, Cluj-Napoca, Romania. 5. Clinic of Periodontology, Philipps University Marburg, Georg-Voigt Str. 3, 35039, Marburg, Germany. 6. Faculty of Economical Sciences, University Babes-Bolyai, str. Universitatii 7-9, 400084, Cluj-Napoca, Romania. 7. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland.
Abstract
OBJECTIVES: To compare the effect of non-surgical periodontal therapy on clinical and inflammatory parameters in patients with moderate to severe chronic periodontitis (CP) and rheumatoid arthritis (RA) (RA-CP) with that in CP patients without RA. MATERIAL AND METHODS: Eighteen patients with RA-CP and 18 systemically healthy patients with CP were treated with scaling and root planing (SRP) within 24 h. At baseline, and at 3 and 6 months after SRP, clinical periodontal parameters, inflammatory markers, and microorganisms in subgingival biofilm were assessed. In addition, disease activity markers of RA (DAS28, CRP, ESR) and specific antibodies (RF) were monitored in the RA-CP group. RESULTS: In both groups, non-surgical therapy yielded to statistically significant improvements in all investigated clinical periodontal variables; in RA patients, a statistically significant decrease in serum-CRP was seen at 3 months. At all time-points, levels of inflammatory markers in GCF were higher in RA-CP than in CP patients. Counts of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola decreased statistically significantly in CP but not in the RA-CP group. Changes of DAS28 correlated positively with those of P. gingivalis and negatively with the plaque index. CONCLUSIONS: Within their limits, the present data suggest that (a) non-surgical periodontal therapy improves periodontal conditions in CP patients with and without RA and (b) in patients with RA, eradication of P. gingivalis in conjunction with a high level oral hygiene may transiently decrease disease activity of RA. CLINICAL RELEVANCE: In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity.
OBJECTIVES: To compare the effect of non-surgical periodontal therapy on clinical and inflammatory parameters in patients with moderate to severe chronic periodontitis (CP) and rheumatoid arthritis (RA) (RA-CP) with that in CP patients without RA. MATERIAL AND METHODS: Eighteen patients with RA-CP and 18 systemically healthy patients with CP were treated with scaling and root planing (SRP) within 24 h. At baseline, and at 3 and 6 months after SRP, clinical periodontal parameters, inflammatory markers, and microorganisms in subgingival biofilm were assessed. In addition, disease activity markers of RA (DAS28, CRP, ESR) and specific antibodies (RF) were monitored in the RA-CP group. RESULTS: In both groups, non-surgical therapy yielded to statistically significant improvements in all investigated clinical periodontal variables; in RApatients, a statistically significant decrease in serum-CRP was seen at 3 months. At all time-points, levels of inflammatory markers in GCF were higher in RA-CP than in CP patients. Counts of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola decreased statistically significantly in CP but not in the RA-CP group. Changes of DAS28 correlated positively with those of P. gingivalis and negatively with the plaque index. CONCLUSIONS: Within their limits, the present data suggest that (a) non-surgical periodontal therapy improves periodontal conditions in CP patients with and without RA and (b) in patients with RA, eradication of P. gingivalis in conjunction with a high level oral hygiene may transiently decrease disease activity of RA. CLINICAL RELEVANCE: In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity.
Authors: William Buwembo; Ian Guyton Munabi; Mark Kaddumukasa; Haruna Kiryowa; Muhammad Mbabali; Ethel Nankya; William Evan Johnson; Emmy Okello; Nelson K Sewankambo Journal: J Dent Res Dent Clin Dent Prospects Date: 2020
Authors: Rafael Scaf de Molon; Carlos Rossa; Rogier M Thurlings; Joni Augusto Cirelli; Marije I Koenders Journal: Int J Mol Sci Date: 2019-09-13 Impact factor: 5.923
Authors: Raluca Cosgarea; S Eick; S Jepsen; N B Arweiler; R Juncar; R Tristiu; G E Salvi; C Heumann; A Sculean Journal: Sci Rep Date: 2020-10-01 Impact factor: 4.379