| Literature DB >> 29588218 |
Giovanna Ramirez-Barbieri1, Kamila Moskowitzova1, Borami Shin1, David Blitzer1, Arzoo Orfany1, Alvise Guariento1, Khadija Iken2, Ingeborg Friehs1, David Zurakowski1, Pedro J Del Nido1, James D McCully3.
Abstract
Previously, we have demonstrated that the transplantation of autologous mitochondria is cardioprotective. No immune or autoimmune response was detectable following the single injection of autologous mitochondria. To expand the therapeutic potential and safety of mitochondrial transplantation, we now investigate the immune response to single and serial injections of syngeneic and allogeneic mitochondria delivered by intraperitoneal injection. Our results demonstrate that there is no direct or indirect, acute or chronic alloreactivity, allorecognition or damage-associated molecular pattern molecules (DAMPs) reaction to single or serial injections of either syngeneic or allogeneic mitochondria.Keywords: Allogeneic; Alloreactivity; Immune response; Mitochondria; Skin allograft; Syngeneic allogeneic
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Year: 2018 PMID： 29588218 DOI： 10.1016/j.mito.2018.03.002
Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160