Literature DB >> 29588163

The involvement of plasmacytoid cells in HIV infection and pathogenesis.

Alessandra Aiello1, Flavia Giannessi2, Zulema A Percario3, Elisabetta Affabris4.   

Abstract

Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset that are specialized in type I interferon (IFN) production. pDCs are key players in the antiviral immune response and serve as bridge between innate and adaptive immunity. Although pDCs do not represent the main reservoir of the Human Immunodeficiency Virus (HIV), they are a crucial subset in HIV infection as they influence viral transmission, target cell infection and antigen presentation. pDCs act as inflammatory and immunosuppressive cells, thus contributing to HIV disease progression. This review provides a state of art analysis of the interactions between HIV and pDCs and their potential roles in HIV transmission, chronic immune activation and immunosuppression. A thorough understanding of the roles of pDCs in HIV infection will help to improve therapeutic strategies to fight HIV infection, and will further increase our knowledge on this important immune cell subset.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV infection; Immune activation; Plasmacytoid cells; Type I interferon

Mesh：

Substances：

Year:  2018        PMID： 29588163     DOI： 10.1016/j.cytogfr.2018.03.009

Source DB:  PubMed          Journal:  Cytokine Growth Factor Rev        ISSN： 1359-6101            Impact factor:   7.638


  9 in total

1.  Leukemia Inhibitory Factor Inhibits Plasmacytoid Dendritic Cell Function and Development.

Authors:  Renata Sesti-Costa; Luisa Cervantes-Barragan; Melissa K Swiecki; José Luís Fachi; Marina Cella; Susan Gilfillan; João Santana Silva; Marco Colonna
Journal:  J Immunol       Date:  2020-03-13       Impact factor: 5.422

Review 2.  HIV-1 Infection and Type 1 Interferon: Navigating Through Uncertain Waters.

Authors:  Sho Sugawara; David L Thomas; Ashwin Balagopal
Journal:  AIDS Res Hum Retroviruses       Date:  2018-08-15       Impact factor: 2.205

3.  Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery.

Authors:  Birgitte Stiksrud; Hans C D Aass; Kristina B Lorvik; Thor Ueland; Marius Trøseid; Anne M Dyrhol-Riise
Journal:  AIDS       Date:  2019-06-01       Impact factor: 4.177

Review 4.  Plasmacytoid Dendritic Cells: Development, Regulation, and Function.

Authors:  Boris Reizis
Journal:  Immunity       Date:  2019-01-15       Impact factor: 31.745

Review 5.  Manipulation of Mononuclear Phagocytes by HIV: Implications for Early Transmission Events.

Authors:  Kirstie Melissa Bertram; Orion Tong; Caroline Royle; Stuart Grant Turville; Najla Nasr; Anthony Lawrence Cunningham; Andrew Nicholas Harman
Journal:  Front Immunol       Date:  2019-09-24       Impact factor: 7.561

Review 6.  Type I Interferon Production of Plasmacytoid Dendritic Cells under Control.

Authors:  Dóra Bencze; Tünde Fekete; Kitti Pázmándi
Journal:  Int J Mol Sci       Date:  2021-04-18       Impact factor: 5.923

Review 7.  The Role of Dendritic Cells During Infections Caused by Highly Prevalent Viruses.

Authors:  Jorge A Soto; Nicolas M S Gálvez; Catalina A Andrade; Gaspar A Pacheco; Karen Bohmwald; Roslye V Berrios; Susan M Bueno; Alexis M Kalergis
Journal:  Front Immunol       Date:  2020-07-16       Impact factor: 7.561

8.  HIV-1 Nef Protein Affects Cytokine and Extracellular Vesicles Production in the GEN2.2 Plasmacytoid Dendritic Cell Line.

Authors:  Alessandra Aiello; Flavia Giannessi; Zulema Antonia Percario; Katia Fecchi; Claudia Arenaccio; Stefano Leone; Maria Carollo; Elisabetta D'Aversa; Laurence Chaperot; Roberto Gambari; Massimo Sargiacomo; Elisabetta Affabris
Journal:  Viruses       Date:  2021-12-31       Impact factor: 5.048

9.  Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.

Authors:  Michelle Y-H Lee; Amit A Upadhyay; Hasse Walum; Chi N Chan; Reem A Dawoud; Christine Grech; Justin L Harper; Kirti A Karunakaran; Sydney A Nelson; Ernestine A Mahar; Kyndal L Goss; Diane G Carnathan; Barbara Cervasi; Kiran Gill; Gregory K Tharp; Elizabeth R Wonderlich; Vijayakumar Velu; Simon M Barratt-Boyes; Mirko Paiardini; Guido Silvestri; Jacob D Estes; Steven E Bosinger
Journal:  PLoS Pathog       Date:  2021-06-28       Impact factor: 6.823
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.