A J Richardson1, T Leckie2, E R Watkins3, D Fitzpatrick4, R Galloway5, R Grimaldi5, P Baker6. 1. Centre of Sport and Exercise Medicine (SESAME), University of Brighton, Welkin Laboratories, UK; Brighton Marathon Research Group, UK. Electronic address: A.J.Richardson@brighton.ac.uk. 2. Anaesthetics Department, Eastbourne DGH, East Sussex Healthcare Trust, UK; Brighton Marathon Research Group, UK. 3. Centre of Sport and Exercise Medicine (SESAME), University of Brighton, Welkin Laboratories, UK. 4. University Hospital Lewisham, UK. 5. Royal Sussex County Hospital, Brighton and Sussex Hospital NHS Trust, UK; Brighton Marathon Research Group, UK. 6. Centre of Sport and Exercise Medicine (SESAME), University of Brighton, Welkin Laboratories, UK; Brighton Marathon Research Group, UK.
Abstract
OBJECTIVES: This study aimed to investigate whether measures of cardiopulmonary fitness and relative exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a road marathon. METHODS: Fifty-two marathon runners (age 39±11 years, body mass 76.2±12.9kg, height 1.74±0.09m) attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Running economy at 10kmh-1 (RE10) and race pace (RERP), ventilatory threshold (VT) and VO2max tests were completed. CTnT was measured within 48h prior to the marathon and within 10min of completing the marathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon. RESULTS: Runners demonstrated a significant increase in cTnT over the marathon (pre-race 5.60±3.27ngL-1, post-race 74.52±30.39ngL-1, p<0.001). Markers of endurance performance such as running economy (10kmh-1 223±18mlkg-1km-1; race pace 225±22mlkg-1km-1), VT (38.5±6.4mlkg-1min-1) and V˙O2max (50.9±7.7mlkg-1min-1) were not associated with post-race cTnT. Runners exercise intensity correlated with post-race cTnT (mean HR %VT 104±5%, r=0.50; peak HR %VT 118±8%, r=0.68; peak HR %V˙O2max 96±6, r=0.60, p<0.05) and was different between the low, medium and high cTnT groups (p<0.05). CONCLUSIONS: CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related to exercise intensity relative to ventilatory threshold and V˙O2max, but not individuals' absolute cardiopulmonary fitness, training state or running history.
OBJECTIVES: This study aimed to investigate whether measures of cardiopulmonary fitness and relative exercise intensity were associated with high sensitivity cardiac troponin T (cTnT) rise after a road marathon. METHODS: Fifty-two marathon runners (age 39±11 years, body mass 76.2±12.9kg, height 1.74±0.09m) attended the laboratory between 2 and 3 weeks prior to attempting the Brighton Marathon, UK. Running economy at 10kmh-1 (RE10) and race pace (RERP), ventilatory threshold (VT) and VO2max tests were completed. CTnT was measured within 48h prior to the marathon and within 10min of completing the marathon, using a high sensitivity assay. Heart rates (HR) were recorded throughout the marathon. RESULTS: Runners demonstrated a significant increase in cTnT over the marathon (pre-race 5.60±3.27ngL-1, post-race 74.52±30.39ngL-1, p<0.001). Markers of endurance performance such as running economy (10kmh-1 223±18mlkg-1km-1; race pace 225±22mlkg-1km-1), VT (38.5±6.4mlkg-1min-1) and V˙O2max (50.9±7.7mlkg-1min-1) were not associated with post-race cTnT. Runners exercise intensity correlated with post-race cTnT (mean HR %VT 104±5%, r=0.50; peak HR %VT 118±8%, r=0.68; peak HR %V˙O2max 96±6, r=0.60, p<0.05) and was different between the low, medium and high cTnT groups (p<0.05). CONCLUSIONS:CTnT increases above reference limits during a marathon. Magnitude of cTnT rise is related to exercise intensity relative to ventilatory threshold and V˙O2max, but not individuals' absolute cardiopulmonary fitness, training state or running history.
Authors: Tom Danielsson; Hendrik Schreyer; Hanna Woksepp; Therese Johansson; Patrick Bergman; Alf Månsson; Jörg Carlsson Journal: BMJ Open Sport Exerc Med Date: 2019-01-21
Authors: Feifei Li; Will G Hopkins; Xuejing Wang; Julien S Baker; Jinlei Nie; Junqiang Qiu; Binh Quach; Kun Wang; Longyan Yi Journal: Front Physiol Date: 2021-03-26 Impact factor: 4.566
Authors: Feifei Li; Jinlei Nie; Haifeng Zhang; Frank Fu; Longyan Yi; Will Hopkins; Yang Liu; Yifan Lu Journal: Front Physiol Date: 2020-01-31 Impact factor: 4.566