Literature DB >> 2958493

Helper activity by human large granular lymphocytes in in vitro immunoglobulin synthesis.

M A Rodriguez1, I Blanca, M L Baroja, S Arama, M Leon-Ponte, I Abadi, N E Bianco.   

Abstract

In the present study we have examined the effect of human large granular lymphocytes (LGL) from healthy donors on Ig synthesis by autologous B lymphocytes. The results showed that this cell population has a consistent helper activity in pokeweed mitogen-activated cultures even when added at very low numbers. LGL can mediate their effect by secreting soluble helper factors capable of modulating B-cell responses as evidenced by the enhancement of IgG and IgM production by supernatants obtained from LGL cultures. Preincubation with interferon gamma further potentiated the helper activity by LGL.

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Year:  1987        PMID： 2958493     DOI： 10.1007/bf00917013

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  28 in total

1.  Noncytotoxic functions of natural killer (NK) cells: large granular lymphocytes (LGL) produce a B cell growth factor (BCGF).

Authors:  A D Procopio; P Allavena; J R Ortaldo
Journal:  J Immunol       Date:  1985-11       Impact factor: 5.422

2.  Subsets of human large granular lymphocytes (LGL) exhibit accessory cell functions.

Authors:  G Scala; P Allavena; J R Ortaldo; R B Herberman; J J Oppenheim
Journal:  J Immunol       Date:  1985-05       Impact factor: 5.422

3.  The T cell dependence of B cell differentiation induced by pokeweed mitogen.

Authors:  R G Keightley; M D Cooper; A R Lawton
Journal:  J Immunol       Date:  1976-11       Impact factor: 5.422

4.  Inhibition of human antigen-induced lymphoblastoid B-cell function by an in vivo-induced suppressor T cell.

Authors:  J A Brieva; R H Stevens
Journal:  Cell Immunol       Date:  1983-04-01       Impact factor: 4.868

5.  NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.

Authors:  J A Brieva; S Targan; R H Stevens
Journal:  J Immunol       Date:  1984-02       Impact factor: 5.422

6.  Suppressive effect of human natural killer cells on pokeweed mitogen-induced B cell differentiation.

Authors:  S Arai; H Yamamoto; K Itoh; K Kumagai
Journal:  J Immunol       Date:  1983-08       Impact factor: 5.422

7.  Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2.

Authors:  P Ralph; G Jeong; K Welte; R Mertelsmann; H Rabin; L E Henderson; L M Souza; T C Boone; R J Robb
Journal:  J Immunol       Date:  1984-11       Impact factor: 5.422

8.  Regulation of human B cell activation by prostaglandin E2. Suppression of the generation of immunoglobulin-secreting cells.

Authors:  D F Jelinek; P A Thompson; P E Lipsky
Journal:  J Clin Invest       Date:  1985-04       Impact factor: 14.808

9.  The role of interleukin 1 in human B cell activation: inhibition of B cell proliferation and the generation of immunoglobulin-secreting cells by an antibody against human leukocytic pyrogen.

Authors:  P E Lipsky; P A Thompson; L J Rosenwasser; C A Dinarello
Journal:  J Immunol       Date:  1983-06       Impact factor: 5.422

10.  Suppressor cell function of human granular lymphocytes identified by the HNK-1 (Leu 7) monoclonal antibody.

Authors:  A B Tilden; T Abo; C M Balch
Journal:  J Immunol       Date:  1983-03       Impact factor: 5.422
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  6 in total

1.  Suppression of in vitro immunoglobulin synthesis by CD16(Leu11a)+ CD56 (NKH1,Leu19)+non-T lineage NK cells; lack of suppression of cells from immunodeficient patients.

Authors:  T Morio; S Nonoyama; J Yata
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

2.  Bone marrow and peripheral blood natural killer cell activity in lymphomas. Its response to IL-2.

Authors:  L H Caldera; M Leon-Ponte; G Acquatella; N E Bianco; I Blanca
Journal:  Clin Exp Immunol       Date:  1992-04       Impact factor: 4.330

3.  Expression of low-density lipoprotein receptors in peripheral blood and tonsil B lymphocytes.

Authors:  J B De Sanctis; I Blanca; H Rivera; N E Bianco
Journal:  Clin Exp Immunol       Date:  1998-08       Impact factor: 4.330

4.  Human IFN-gamma up-regulates IL-2 receptors in mitogen-activated T lymphocytes.

Authors:  M A Rodriguez; J B De Sanctis; A M Blasini; M Leon-Ponte; I Abadi
Journal:  Immunology       Date:  1990-04       Impact factor: 7.397

5.  Human natural killer (NK) cells produce a late-acting B-cell differentiation activity.

Authors:  H Kimata; E H Sherr; A Saxon
Journal:  J Clin Immunol       Date:  1988-09       Impact factor: 8.317

6.  Increased proportion of responders to a murine anti-CD3 monoclonal antibody of the IgG1 class in patients with systemic lupus erythematosus (SLE).

Authors:  A M Blasini; I L Stekman; M Leon-Ponte; D Caldera; M A Rodriguez
Journal:  Clin Exp Immunol       Date:  1993-12       Impact factor: 4.330
  6 in total

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