Akiko Suwa1, Nobuyuki Horita2, Takehito Ishido1, Masaki Takeuchi1, Tatsukata Kawagoe1, Etsuko Shibuya1, Takahiro Yamane1, Takahiko Hayashi1, Akira Meguro1, Mizuho Ishido1, Kaoru Minegishi3, Ryusuke Yoshimi3, Yohei Kirino3, Shingo Kato4, Jun Arimoto4, Takeshi Fukumoto5, Yoshiaki Ishigatsubo6, Michiko Kurosawa7, Takeshi Kaneko2, Mitsuhiro Takeno8, Nobuhisa Mizuki1. 1. a Department of Ophthalmology and Visual Science , Yokohama City University Graduate School of Medicine , Yokohama , Japan. 2. b Department of Pulmonology , Yokohama City University Graduate School of Medicine , Yokohama , Japan. 3. c Department of Stem Cell and Immune Regulation , Yokohama City University Graduate School of Medicine , Yokohama , Japan. 4. d Department of Gastroenterology and Hepatology , Yokohama City University School of Medicine , Yokohama , Japan. 5. e Gene Expression and Regulation Program , The Wistar Institute , Philadelphia , PA , USA. 6. f Yokohama City University Graduate School of Medicine , Yokohama , Japan. 7. g Department of Epidemiology and Environmental Health , Juntendo University Faculty of Medicine , Tokyo , Japan. 8. h Department of Allergy and Rheumatology , Nippon Medical School Graduate School of Medicine , Tokyo , Japan.
Abstract
OBJECTIVES: This study aimed to identify patients with high-probability of ocular involvement of Behçet's disease (BD). METHODS: The Japanese Ministry of Health, Labour and Welfare provided dataset of ongoing nationwide BD registration project. A patient who had confirmed BD and who was suspected to have BD was registered. We mainly analyzed newly registered patients who had the data for all demographic and diagnostic parameters regardless of fulfilment of any diagnostic criteria. RESULTS: Among 3213 patients with confirmed or possible BD, 1382 (43.0%) were men and 1831 (57.0%) were women with a median age of 38 years (interquartile range (IQR) 30-49 years). The median duration between onset and registration was 0 year (IQR 0-3). A binomial multivariable logistic regression analysis revealed that being female (odds ratio (OR) 0.63, 95% confidence interval (CI) 0.53-0.75, p < .001), duration since onset (OR 1.33 per 10 years, 95% CI 1.18-1.51, p < .001), genital ulceration (OR 0.28, 95% CI 0.23-0.34, p < .001), and gastrointestinal symptoms (OR 0.36, 95% CI 0.30-0.44, p < .001) were related to the ocular lesion. Analyses based on data of 2800 patients who satisfied International criteria of BD, age-, sex-, duration-based subgroup analyses, analyses targeting iridocyclitis and retino-uveitis, and analysis including patients with missing data confirmed that the four factors were associated with the probability of eye involvement. CONCLUSION: The ocular involvement did not accompany with genital ulcer or gastrointestinal symptoms at the early stage of BD.
OBJECTIVES: This study aimed to identify patients with high-probability of ocular involvement of Behçet's disease (BD). METHODS: The Japanese Ministry of Health, Labour and Welfare provided dataset of ongoing nationwide BD registration project. A patient who had confirmed BD and who was suspected to have BD was registered. We mainly analyzed newly registered patients who had the data for all demographic and diagnostic parameters regardless of fulfilment of any diagnostic criteria. RESULTS: Among 3213 patients with confirmed or possible BD, 1382 (43.0%) were men and 1831 (57.0%) were women with a median age of 38 years (interquartile range (IQR) 30-49 years). The median duration between onset and registration was 0 year (IQR 0-3). A binomial multivariable logistic regression analysis revealed that being female (odds ratio (OR) 0.63, 95% confidence interval (CI) 0.53-0.75, p < .001), duration since onset (OR 1.33 per 10 years, 95% CI 1.18-1.51, p < .001), genital ulceration (OR 0.28, 95% CI 0.23-0.34, p < .001), and gastrointestinal symptoms (OR 0.36, 95% CI 0.30-0.44, p < .001) were related to the ocular lesion. Analyses based on data of 2800 patients who satisfied International criteria of BD, age-, sex-, duration-based subgroup analyses, analyses targeting iridocyclitis and retino-uveitis, and analysis including patients with missing data confirmed that the four factors were associated with the probability of eye involvement. CONCLUSION: The ocular involvement did not accompany with genital ulcer or gastrointestinal symptoms at the early stage of BD.
Entities:
Keywords:
Behçet’s syndrome; epidemiology; surveys and questionnaires; uveitis
Authors: Jurgen Sota; Donato Rigante; Giacomo Emmi; Giuseppe Lopalco; Ida Orlando; Gian Marco Tosi; Bruno Frediani; Antonio Vitale; Silvana Guerriero; Florenzo Iannone; Lorenzo Vannozzi; Claudia Fabiani; Luca Cantarini Journal: Intern Emerg Med Date: 2020-02-01 Impact factor: 3.397