Literature DB >> 29581622

Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report.

Kenichi Nishie1,2, Masanori Yasuo1, Yoshiaki Kitaguchi1, Nobumitsu Kobayashi1, Kazunari Tateishi1, Atsuhito Ushiki1, Kazuhisa Urushihata1, Hiroshi Yamamoto1, Gen Ideura3, Masayuki Hanaoka1.   

Abstract

A 66-year-old male with advanced non-small-cell lung cancer (NSCLC) who was previously treated with carboplatin, pemetrexed, and bevacizumab consequently suffered from severe coughing during deglutition. Chest computed tomography (CT) revealed a tracheoesophageal fistula (TEF) between the left main bronchus and esophagus through a subcarinal metastatic lymph node. Given the extreme swelling of the lymph node due to metastatic cancer, it was determined that the walls of the bronchus and esophagus had been injured simultaneously. Delayed and dysfunctional wound healing due to bevacizumab resulted in necrosis of the contact region leading to fistula formation. This case suggests that using bevacizumab for NSCLC in patients with bulky subcarinal lymphadenopathy may increase the risk for TEF.

Entities:  

Keywords:  bevacizumab; non-small-cell lung cancer; tracheoesophageal fistula

Mesh：

Substances：

Year:  2018        PMID： 29581622      PMCID： PMC5857509          DOI： 10.18999/nagjms.80.1.129

Source DB:  PubMed          Journal:  Nagoya J Med Sci        ISSN： 0027-7622            Impact factor:   1.131


  9 in total

1.  Tracheoesophageal fistula associated with bevacizumab 21 months after completion of radiation therapy.

Authors:  Elizabeth Gore; Adam Currey; Nicholas Choong
Journal:  J Thorac Oncol       Date:  2009-12       Impact factor: 15.609

2.  Tracheo-esophageal fistula with bevacizumab after mediastinal radiation.

Authors:  Boone Goodgame; Nirmal Veeramachaneni; Alexander Patterson; Ramaswamy Govindan
Journal:  J Thorac Oncol       Date:  2008-09       Impact factor: 15.609

3.  Bronchoesophageal fistula and fatal hemoptysis after bevacizumab-containing chemotherapy without radiation in lung cancer.

Authors:  Jens Schreiber; Nadine Waldburg
Journal:  J Clin Oncol       Date:  2012-09-24       Impact factor: 44.544

4.  Tracheoesophageal fistula due to cancer.

Authors:  N Martini; J T Goodner; G J D'Angio; E J Beattie
Journal:  J Thorac Cardiovasc Surg       Date:  1970-03       Impact factor: 5.209

5.  Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab.

Authors:  David R Spigel; John D Hainsworth; Denise A Yardley; Eric Raefsky; Jeffrey Patton; Nancy Peacock; Cindy Farley; Howard A Burris; F Anthony Greco
Journal:  J Clin Oncol       Date:  2009-11-09       Impact factor: 44.544

6.  Esophagorespiratory fistulas of tumorous origin. Non-operative management of 264 cases in a 20-year period.

Authors:  Akos Balazs; Peter K Kupcsulik; Zoltan Galambos
Journal:  Eur J Cardiothorac Surg       Date:  2008-08-03       Impact factor: 4.191

7.  Incorporating bevacizumab and erlotinib in the combined-modality treatment of stage III non-small-cell lung cancer: results of a phase I/II trial.

Authors:  Mark A Socinski; Thomas E Stinchcombe; Dominic T Moore; Scott N Gettinger; Roy H Decker; W Jeffrey Petty; A William Blackstock; Garry Schwartz; Scott Lankford; Amir Khandani; David E Morris
Journal:  J Clin Oncol       Date:  2012-10-08       Impact factor: 44.544

Review 8.  Tracheoesophageal fistula.

Authors:  Michael F Reed; Douglas J Mathisen
Journal:  Chest Surg Clin N Am       Date:  2003-05

9.  Pulmonary hilar lymph node metastasis of breast cancer induced bronchopleural fistula and superior vena cava syndrome.

Authors:  Yutaka Nishinari; Masahiro Kashiwaba; Akira Umemura; Hideaki Komatsu; Akira Sasaki; Go Wakabayashi
Journal:  Am J Case Rep       Date:  2014-11-12
  9 in total
  6 in total

1.  Combination of Palliative Thoracic Radiotherapy With Bevacizumab for Stage IV Nonsquamous NSCLC: Is There Any Impact of Time Interval on Survival?

Authors:  Weigang Xiu; Xiaotong Guo; Min Yu; Yanying Li; Yong Xu; Jiang Zhu; Jingjing Luo
Journal:  Clin Med Insights Oncol       Date:  2022-06-24

2.  Tracheomediastinal Fistula Formation After Endobronchial Ultrasound Transbronchial Needle Aspiration While on Bevacizumab Treatment.

Authors:  Alejandra Castro-Varela; Sofia Molina; Horiana B Grosu
Journal:  Cureus       Date:  2021-03-30

3.  Bevacizumab-induced esophageal pleural fistula during maintenance therapy without radiation in lung cancer.

Authors:  Ting Wang; Asmitananda Thakur; Baoqing Chen
Journal:  BMC Pulm Med       Date:  2021-11-25       Impact factor: 3.317

4.  Endostar (rh-endostatin) improves efficacy of concurrent chemoradiotherapy for locally advanced non-small cell lung cancer: A systematic review and meta-analysis.

Authors:  Meng Yuan; Yirui Zhai; Yu Men; Jianyang Wang; Lei Deng; Wenqing Wang; Yongxing Bao; Xu Yang; Shuang Sun; Zeliang Ma; Yunsong Liu; Jun Wang; Hui Zhu; Zhouguang Hui
Journal:  Thorac Cancer       Date:  2021-10-21       Impact factor: 3.500

5.  Bronchial Fistula: Rare Complication of Treatment with Anlotinib.

Authors:  Pengbo Deng; Chengping Hu; Yuanyuan Li; Liming Cao; Huaping Yang; Min Li; Jian An; Juan Jiang; Qihua Gu
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2020-09-29

6.  Tracheoesophageal fistula associated with bevacizumab after thoracic radiotherapy in non-small cell lung cancer: A case report.

Authors:  Tao Zhang; Yin Yang; Guowei Cheng; Ping Chen; Nan Bi
Journal:  Medicine (Baltimore)       Date:  2020-04       Impact factor: 1.817
  6 in total

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