Literature DB >> 29581133

The Long Neglected Player: Modeling Tumor Uptake to Guide Optimal Dosing.

Leire Ruiz-Cerdá1,2, Eduardo Asín-Prieto1,2, Zinnia P Parra-Guillen1,2, Iñaki F Trocóniz3,2.   

Abstract

Pharmacokinetic modeling, traditionally using drug exposure, is widely used to support decision-making in translational medicine and patient care. The development of mechanistic computational models that integrate drug concentrations at the site of action making use of existing knowledge opens a new paradigm in optimal dosing. Clin Cancer Res; 24(14); 3236-8. ©2018 AACRSee related article by Ribba et al., p. 3325. ©2018 American Association for Cancer Research.

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Year:  2018        PMID： 29581133     DOI： 10.1158/1078-0432.CCR-18-0580

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  4 in total

Review 1.  Drug Exposure to Establish Pharmacokinetic-Response Relationships in Oncology.

Authors:  Belén P Solans; María Jesús Garrido; Iñaki F Trocóniz
Journal:  Clin Pharmacokinet       Date:  2020-02       Impact factor: 6.447

2.  Predicting Therapeutic Antibody Delivery into Human Head and Neck Cancers.

Authors:  Guolan Lu; Shayan Fakurnejad; Brock A Martin; Nynke S van den Berg; Stan van Keulen; Naoki Nishio; Ashley J Zhu; Stefania U Chirita; Quan Zhou; Rebecca W Gao; Christina S Kong; Nancy Fischbein; Mrudula Penta; Alexander D Colevas; Eben L Rosenthal
Journal:  Clin Cancer Res       Date:  2020-01-24       Impact factor: 13.801

Review 3.  Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors.

Authors:  Maddalena Centanni; Dirk Jan A R Moes; Iñaki F Trocóniz; Joseph Ciccolini; J G Coen van Hasselt
Journal:  Clin Pharmacokinet       Date:  2019-07       Impact factor: 6.447

Review 4.  Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle.

Authors:  Imke H Bartelink; Ella F Jones; Sheerin K Shahidi-Latham; Pei Rong Evelyn Lee; Yanan Zheng; Paolo Vicini; Laura van 't Veer; Denise Wolf; Andrei Iagaru; Deanna L Kroetz; Brendan Prideaux; Cornelius Cilliers; Greg M Thurber; Zena Wimana; Geraldine Gebhart
Journal:  Clin Pharmacol Ther       Date:  2018-10-06       Impact factor: 6.875
  4 in total

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