Enrique Rodriguez-Garcia1, Josefina Ruiz-Nava2, Sonia Santamaria-Fernandez3, Jose Carlos Fernandez-Garcia4, Antonio Vargas-Candela5, Raquel Yahyaoui6, Francisco J Tinahones2, M Rosa Bernal-Lopez7, Ricardo Gomez-Huelgas5. 1. Clinical Laboratory, Regional University Hospital of Malaga, Malaga, Spain; Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; University of Malaga (UMA), Spain. 2. Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; Endocrinology and Nutrition Department, Regional University Hospital of Malaga (Virgen de la Victoria Hospital), Spain; CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain. 3. Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; Internal Medicine Department, Regional University Hospital of Málaga (Carlos Haya Hospital), Spain. 4. Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; University of Malaga (UMA), Spain; Faculty of Education Sciences, Malaga, Spain; CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain. 5. Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; Internal Medicine Department, Regional University Hospital of Málaga (Carlos Haya Hospital), Spain; CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain. 6. Clinical Laboratory, Regional University Hospital of Malaga, Malaga, Spain. 7. Institute of Biomedical Research in Malaga (IBIMA), Malaga, Spain; Internal Medicine Department, Regional University Hospital of Málaga (Carlos Haya Hospital), Spain; CIBER Fisiopatologia de la Obesidad y la Nutricion, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: robelopajiju@yahoo.es.
Abstract
OBJECTIVE: There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects' lipid profiles. Our objective was to characterize lipoprotein size, particle and subclass concentration using 1H NMR in MHO women after two years of weight loss with a hypocaloric Mediterranean diet and physical exercise. METHODS: 115 non-diabetic women (aged 35-55 years) with a body mass index (BMI) of 30-40 kg/m2 and ≤1 of the following criteria: blood pressure ≥135/85 mmHg, fasting plasma glucose ≥100 mg/dL, HDL cholesterol ≤50 mg/dL and triglycerides ≥150 mg/dL were included. After two years of intensive lifestyle modification (Mediterranean diet and physical exercise), they were classified according to their weight loss: <5%, ≥5%-<10% and ≥10%. Lipoprotein size, particle and subclass concentrations were measured using 1H NMR. RESULTS: The final population, after dropouts, were 67 women (age: 44.5 ± 3.7 years, BMI: 36.3 ± 4.7 kg/m2), of whom 23 (38.3%) lost <5%, and 22 (36.7%), lost ≥5% to <10% and ≥10% of baseline body weight, respectively. The lipid profile showed no significant changes after intervention, especially in small LDL particles or in production of HDL. The diameter of LDL and HDL particles did not change after two years of a Mediterranean diet and physical exercise. CONCLUSION: These results indicate that intensive lifestyle modification does not produce significant changes in the lipid profile of MHO women. Levels of more atherogenic or atheroprotective particles did not change after two years, despite the intervention.
OBJECTIVE: There is a lack of consensus when it comes to establishing the biochemical parameters that define metabolically healthy obese (MHO) subjects. Indeed, most studies do not include subjects' lipid profiles. Our objective was to characterize lipoprotein size, particle and subclass concentration using 1H NMR in MHO women after two years of weight loss with a hypocaloric Mediterranean diet and physical exercise. METHODS: 115 non-diabeticwomen (aged 35-55 years) with a body mass index (BMI) of 30-40 kg/m2 and ≤1 of the following criteria: blood pressure ≥135/85 mmHg, fasting plasma glucose ≥100 mg/dL, HDL cholesterol ≤50 mg/dL and triglycerides ≥150 mg/dL were included. After two years of intensive lifestyle modification (Mediterranean diet and physical exercise), they were classified according to their weight loss: <5%, ≥5%-<10% and ≥10%. Lipoprotein size, particle and subclass concentrations were measured using 1H NMR. RESULTS: The final population, after dropouts, were 67 women (age: 44.5 ± 3.7 years, BMI: 36.3 ± 4.7 kg/m2), of whom 23 (38.3%) lost <5%, and 22 (36.7%), lost ≥5% to <10% and ≥10% of baseline body weight, respectively. The lipid profile showed no significant changes after intervention, especially in small LDL particles or in production of HDL. The diameter of LDL and HDL particles did not change after two years of a Mediterranean diet and physical exercise. CONCLUSION: These results indicate that intensive lifestyle modification does not produce significant changes in the lipid profile of MHO women. Levels of more atherogenic or atheroprotective particles did not change after two years, despite the intervention.
Authors: Ricardo Gomez-Huelgas; Josefina Ruiz-Nava; Sonia Santamaria-Fernandez; Antonio Vargas-Candela; Ana Victoria Alarcon-Martin; Francisco J Tinahones; M Rosa Bernal-Lopez Journal: Mediators Inflamm Date: 2019-04-09 Impact factor: 4.711
Authors: Maria Isabel Ruiz-Moreno; Alberto Vilches-Perez; Cristina Gallardo-Escribano; Antonio Vargas-Candela; Maria Dolores Lopez-Carmona; Luis Miguel Pérez-Belmonte; Alejandro Ruiz-Moreno; Ricardo Gomez-Huelgas; Maria Rosa Bernal-Lopez Journal: Int J Environ Res Public Health Date: 2020-09-24 Impact factor: 3.390