Livio Mordasini1, Lukas Hechelhammer2, Pierre-André Diener3, Joachim Diebold4, Agostino Mattei5, Daniel Engeler6, Gautier Müllhaupt6, Suk-Kyum Kim2, Hans-Peter Schmid6, Dominik Abt6. 1. Department of Urology, Luzerner Kantonsspital, Spitalstrasse, 6000 Luzern, Switzerland. Electronic address: livio.mordasini@luks.ch. 2. Department of Radiology, Kantonsspital St. Gallen, St. Gallen, Switzerland. 3. Department of Pathology, Kantonsspital St. Gallen, St. Gallen, Switzerland. 4. Department of Pathology, Luzerner Kantonsspital, Spitalstrasse, 6000 Luzern, Switzerland. 5. Department of Urology, Luzerner Kantonsspital, Spitalstrasse, 6000 Luzern, Switzerland. 6. Department of Urology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Abstract
PURPOSE: To provide initial data on tumoricidal efficacy of embolization on prostate cancer via histopathologic examination of prostatectomy specimens after embolization. MATERIALS AND METHODS: In this bicentric prospective trial, 12 men with localized prostate cancer underwent radical prostatectomy 6 weeks after prostatic artery embolization (PAE) from October 2016 to May 2017. PAE was performed with the use of 100-μm Embozene microspheres (Boston Scientific, Natick, Massachusetts). Response of prostate cancer tissue to PAE was assessed according to tumor regression grades. The major outcome measure was complete histopathologic absence of viable cancer cells, including secondary foci, in the prostatectomy specimens. RESULTS: Complete necrosis of the index lesion was found in 2 patients and partial necrosis in 5. Considering secondary cancerous foci, viable cancer cells were found in all 12 patients. Pathologic specimens were characterized by demarcated zones of necrotic tissue predominantly located in the central gland. Two patients required additional surgery to remove necrotic bladder tissue caused by PAE. CONCLUSIONS: PAE with the use of 100-μm microspheres failed to achieve complete elimination of tumor cells. Extensive tumor regression was induced in some lesions, highlighting the need for further assessment of PAE as a potential treatment option for prostate cancer.
PURPOSE: To provide initial data on tumoricidal efficacy of embolization on prostate cancer via histopathologic examination of prostatectomy specimens after embolization. MATERIALS AND METHODS: In this bicentric prospective trial, 12 men with localized prostate cancer underwent radical prostatectomy 6 weeks after prostatic artery embolization (PAE) from October 2016 to May 2017. PAE was performed with the use of 100-μm Embozene microspheres (Boston Scientific, Natick, Massachusetts). Response of prostate cancer tissue to PAE was assessed according to tumor regression grades. The major outcome measure was complete histopathologic absence of viable cancer cells, including secondary foci, in the prostatectomy specimens. RESULTS: Complete necrosis of the index lesion was found in 2 patients and partial necrosis in 5. Considering secondary cancerous foci, viable cancer cells were found in all 12 patients. Pathologic specimens were characterized by demarcated zones of necrotic tissue predominantly located in the central gland. Two patients required additional surgery to remove necrotic bladder tissue caused by PAE. CONCLUSIONS: PAE with the use of 100-μm microspheres failed to achieve complete elimination of tumor cells. Extensive tumor regression was induced in some lesions, highlighting the need for further assessment of PAE as a potential treatment option for prostate cancer.
Authors: Nainesh Parikh; Edward Keshishian; Ayushman Sharma; Monica Roca; Brandon Manley; Michael Poch; G Daniel Grass; Javier Torres-Roca; David Boulware; Peter Johnstone; Michael Montejo; Johnna Smith; Julio Pow-Sang; Kosj Yamoah Journal: Adv Radiat Oncol Date: 2020-04-14
Authors: Mao Qiang Wang; Jin Long Zhang; Kai Yuan; Bing Yuan; Feng Duan; Jie Yu Yan; Yan Wang; Jin Xin Fu Journal: Ther Adv Med Oncol Date: 2020-05-18 Impact factor: 8.168