Dear EditorI read with great interest the article by Jafargholizadeh et al., (2016) for the possible cytotoxic effects of Ecballium elaterium (L.) A. Richard fruit on gastric cancer cells due to its cucurbitacins. Although this toxic herb has been known since antiquity and was mentioned by ancient writers (as Hippocrates, Theophrastus Pliny, Dioscorides, Avicenna and others), Hippocrates was the first who suggested the administration of Ecballium elaterium for the management of gastrointestinal cancer. Particularly, in the Book of Εpidemics II, Hippocrates of Kos (c. 460 - c. 370 BC) wrote the following: “Ἀπό γαστρός ταραχῆς ἤ ἀπό βηχός καρκίνου γινομένου, τό στόμα πικραίνεται∙ διδόναι δέ πίνειν ἐλατήριον δίς ἤ τρίς, ἤν μή ψιλός ᾖ” (If you develop cancer after a digestive disorder or a cough, your mouth becomes bitter. The patient is given elaterium two or three times, unless the patient is thin) (6,22). The administration of elaterium in this text was probably related to its laxative properties. It is worth mentioning that the name Ecballium elaterium originates from the Greek words “ἐκβάλλω” (ekvállo) which means discharge and “ἐλατήριον” (elatírion) which means spring, because of a specific characteristic of the seeds of the plant, which are ejected like springs, even by the lightest touch of the surface of the fruit, when it is ripe.