| Literature DB >> 29579256 |
Deogratius Ssemwanga1, Nicole A Doria-Rose2, Andrew D Redd3,4, Andrea R Shiakolas2, Andrew F Longosz3, Rebecca N Nsubuga1, Billy N Mayanja1, Gershim Asiki1, Janet Seeley1,5, Anatoli Kamali1, Amy Ransier2, Samuel Darko2, Michael P Walker6, Daniel Bruno6, Craig Martens6, Daniel Douek2, Stephen F Porcella6, Thomas C Quinn3,4, John R Mascola2, Pontiano Kaleebu1,5.
Abstract
This report describes the identification of a genetically confirmed linked heterosexual human immunodeficiency virus (HIV) superinfection (HIV-SI) in a woman with chronic HIV infection who acquired a second strain of the virus from her husband. Serum neutralizing antibody (NAb) responses against their homologous and heterologous viruses, including the superinfecting strain, in the woman and her husband were examined before and after onset of HIV-SI. The woman displayed a moderately potent and broad anti-HIV NAb response prior to superinfection but did not possess NAb activity against the superinfecting strain. This case highlights the unique potential of linked HIV-SI studies to examine natural protection from HIV infection.Entities:
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Year: 2018 PMID： 29579256 PMCID： PMC6065500 DOI： 10.1093/infdis/jiy071
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226