Literature DB >> 29578343

Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.

Mark D Ericson, Anamika Singh1, Srinivasa R Tala1, Erica M Haslach1, Marvin L S Dirain1, Jay W Schaub1, Viktor Flores1, Natalie Eick1, Cody J Lensing, Katie T Freeman, Branden A Smeester, Danielle N Adank, Stacey L Wilber, Robert Speth2,3, Carrie Haskell-Luevano1.   

Abstract

β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agonists at the MCRs. Furthermore, mouse β-defensin 1 (BD1) and human BD1 are also MCR micromolar agonists. This work identifies BD1 as an endogenous MCR ligand and clarifies the controversial role of BD3 as a micromolar agonist.

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Year:  2018        PMID： 29578343      PMCID： PMC6007841          DOI： 10.1021/acs.jmedchem.8b00251

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  35 in total

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Authors:  T M Hahn; J F Breininger; D G Baskin; M W Schwartz
Journal:  Nat Neurosci       Date:  1998-08       Impact factor: 24.884

2.  ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.

Authors:  Cheng Yuan Kao; Yin Chen; Yu Hua Zhao; Reen Wu
Journal:  Am J Respir Cell Mol Biol       Date:  2003-01-23       Impact factor: 6.914

3.  Targeted disruption of the melanocortin-4 receptor results in obesity in mice.

Authors:  D Huszar; C A Lynch; V Fairchild-Huntress; J H Dunmore; Q Fang; L R Berkemeier; W Gu; R A Kesterson; B A Boston; R D Cone; F J Smith; L A Campfield; P Burn; F Lee
Journal:  Cell       Date:  1997-01-10       Impact factor: 41.582

4.  Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.

Authors:  W Fan; B A Boston; R A Kesterson; V J Hruby; R D Cone
Journal:  Nature       Date:  1997-01-09       Impact factor: 49.962

5.  A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.

Authors:  A A Butler; R A Kesterson; K Khong; M J Cullen; M A Pelleymounter; J Dekoning; M Baetscher; R D Cone
Journal:  Endocrinology       Date:  2000-09       Impact factor: 4.736

6.  An in Vitro and in Vivo Investigation of Bivalent Ligands That Display Preferential Binding and Functional Activity for Different Melanocortin Receptor Homodimers.

Authors:  Cody J Lensing; Katie T Freeman; Sathya M Schnell; Danielle N Adank; Robert C Speth; Carrie Haskell-Luevano
Journal:  J Med Chem       Date:  2016-03-29       Impact factor: 7.446

7.  Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor.

Authors:  D Lu; D Willard; I R Patel; S Kadwell; L Overton; T Kost; M Luther; W Chen; R P Woychik; W O Wilkison
Journal:  Nature       Date:  1994-10-27       Impact factor: 49.962

8.  Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

Authors:  K G Mountjoy; M T Mortrud; M J Low; R B Simerly; R D Cone
Journal:  Mol Endocrinol       Date:  1994-10

9.  Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes.

Authors:  Stuart G Jarrett; Erin M Wolf Horrell; Mary C Boulanger; John A D'Orazio
Journal:  J Invest Dermatol       Date:  2015-07-13       Impact factor: 8.551

10.  The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage.

Authors:  Stuart G Jarrett; Katharine M Carter; Brent J Shelton; John A D'Orazio
Journal:  Sci Rep       Date:  2017-09-15       Impact factor: 4.996
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