Xueren Gao1, Zhansheng Zhu2, Shulong Zhang3. 1. Department of Microbiology and Immunology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China. 2. Department of Pathology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, China. 3. Department of General Surgery, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, China.
Abstract
OBJECTIVE: MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with the risk of colorectal cancer (CRC) in Chinese population. MATERIALS AND METHODS: In this hospital-based case-control study of 560 cases and 780 age- and gender-matched healthy controls, the miR-146a rs2910164 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: We found that miR-146a rs2910164 polymorphism was not associated with CRC risk. However, the subgroup analysis by gender showed significant associations in male subjects (GG vs. CC: Odds ratios [OR] = 1.54, 95% confidence intervals [CI] = 1.04-2.29, P = 0.03; G vs. C: OR = 1.21, 95% CI = 1.01-1.45, P = 0.04). CONCLUSION: Our study provides evidence that miR-146a rs2910164 polymorphism may play an important role in susceptibility to CRC in Chinese male population.
OBJECTIVE: MicroRNAs-associated single nucleotide polymorphisms are thought to play an important role in cancer development. We investigated the association of miR-146a rs2910164 polymorphism with the risk of colorectal cancer (CRC) in Chinese population. MATERIALS AND METHODS: In this hospital-based case-control study of 560 cases and 780 age- and gender-matched healthy controls, the miR-146a rs2910164 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: We found that miR-146a rs2910164 polymorphism was not associated with CRC risk. However, the subgroup analysis by gender showed significant associations in male subjects (GG vs. CC: Odds ratios [OR] = 1.54, 95% confidence intervals [CI] = 1.04-2.29, P = 0.03; G vs. C: OR = 1.21, 95% CI = 1.01-1.45, P = 0.04). CONCLUSION: Our study provides evidence that miR-146a rs2910164 polymorphism may play an important role in susceptibility to CRC in Chinese male population.