Literature DB >> 29577161

The active role of Ca2+ ions in Aβ-mediated membrane damage.

Michele F M Sciacca1, Irene Monaco, Carmelo La Rosa, Danilo Milardi.   

Abstract

Calcium dysregulation, membrane leakage and Aβ amyloid growth are hallmarks of Alzheimer's disease. Here we show that Ca2+ ions inhibit membrane damage due to amyloid channels but enhance membrane disruption associated with fibers growing on the lipid surface. The similarities with IAPP suggest that this may represent a mechanism common to all proteinopathies.

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Year:  2018        PMID： 29577161     DOI： 10.1039/c8cc01132j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Silymarin's Inhibition and Treatment Effects for Alzheimer's Disease.

Authors:  Hong Guo; Hui Cao; Xiaowei Cui; Wenxiu Zheng; Shanshan Wang; Jiyang Yu; Zhi Chen
Journal:  Molecules       Date:  2019-05-06       Impact factor: 4.411

2.  The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells.

Authors:  Stefania Zimbone; Anna M Santoro; Diego La Mendola; Chiara Giacomelli; Maria L Trincavelli; Marianna F Tomasello; Danilo Milardi; Sara García-Viñuales; Michele F M Sciacca; Claudia Martini; Giulia Grasso
Journal:  Int J Mol Sci       Date:  2020-04-20       Impact factor: 5.923

Review 3.  Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms.

Authors:  Katiuscia Pagano; Simona Tomaselli; Henriette Molinari; Laura Ragona
Journal:  Front Neurosci       Date:  2020-12-22       Impact factor: 4.677

4.  Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.

Authors:  Michele F M Sciacca; Irina Naletova; Maria Laura Giuffrida; Francesco Attanasio
Journal:  ACS Chem Neurosci       Date:  2022-01-26       Impact factor: 4.418

Review 5.  Current understanding of metal ions in the pathogenesis of Alzheimer's disease.

Authors:  Lu Wang; Ya-Ling Yin; Xin-Zi Liu; Peng Shen; Yan-Ge Zheng; Xin-Rui Lan; Cheng-Biao Lu; Jian-Zhi Wang
Journal:  Transl Neurodegener       Date:  2020-04-03       Impact factor: 8.014

6.  The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms Leading to Membrane Damage, Ca2+-Influx and Neurotoxicity.

Authors:  Marco Diociaiuti; Cecilia Bombelli; Laura Zanetti-Polzi; Marcello Belfiore; Raoul Fioravanti; Gianfranco Macchia; Cristiano Giordani
Journal:  Biomolecules       Date:  2019-12-29

7.  Amyloid-β oligomerization monitored by single-molecule stepwise photobleaching.

Authors:  Lara Dresser; Patrick Hunter; Fatima Yendybayeva; Alex L Hargreaves; Jamieson A L Howard; Gareth J O Evans; Mark C Leake; Steven D Quinn
Journal:  Methods       Date:  2020-06-13       Impact factor: 3.608
  7 in total

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