Aggressiveness, violence, homicidality, homicide, and Lyme disease.

BACKGROUND: No study has previously analyzed aggressiveness, homicide, and Lyme disease (LD).
MATERIALS AND METHODS: Retrospective LD chart reviews analyzed aggressiveness, compared 50 homicidal with 50 non-homicidal patients, and analyzed homicides.
RESULTS: Most aggression with LD was impulsive, sometimes provoked by intrusive symptoms, sensory stimulation or frustration and was invariably bizarre and senseless. About 9.6% of LD patients were homicidal with the average diagnosis delay of 9 years. Postinfection findings associated with homicidality that separated from the non-homicidal group within the 95% confidence interval included suicidality, sudden abrupt mood swings, explosive anger, paranoia, anhedonia, hypervigilance, exaggerated startle, disinhibition, nightmares, depersonalization, intrusive aggressive images, dissociative episodes, derealization, intrusive sexual images, marital/family problems, legal problems, substance abuse, depression, panic disorder, memory impairments, neuropathy, cranial nerve symptoms, and decreased libido. Seven LD homicides included predatory aggression, poor impulse control, and psychosis. Some patients have selective hyperacusis to mouth sounds, which I propose may be the result of brain dysfunction causing a disinhibition of a primitive fear of oral predation.
CONCLUSION: LD and the immune, biochemical, neurotransmitter, and the neural circuit reactions to it can cause impairments associated with violence. Many LD patients have no aggressiveness tendencies or only mild degrees of low frustration tolerance and irritability and pose no danger; however, a lesser number experience explosive anger, a lesser number experience homicidal thoughts and impulses, and much lesser number commit homicides. Since such large numbers are affected by LD, this small percent can be highly significant. Much of the violence associated with LD can be avoided with better prevention, diagnosis, and treatment of LD.

Plain language summary

This study was performed because a recent study on Lyme disease (LD) and suicide showed 26% of suicidal patients with late stage LD were also homicidal. Violence and homicide rarely have a single cause, instead there are many contributors, deterrents, and acute triggers. Many infections and the immune reactions to them can be associated with violence, including those transmitted by ticks, lice, mosquitos, and so on. The evidence supporting the association between infections and violence is from evolutionary concepts, epidemiology, historical perspectives, case reports, animal studies, brain chemistry, brain immunology, brain circuits, and medical literature review. In this study, inactive charts of Lyme patients were reviewed and analyzed for aggressiveness, homicidality, and homicide. Most aggression in these patients was associated with poor impulse control, sometimes triggered by intrusive images, thoughts and emotions; sound or other stimulation and frustration, and the resulting aggression was invariably bizarre and senseless. In this study of homicidal Lyme patients, it was found that the average patient diagnosis was delayed by 9 years. Lyme infections caused a broad spectrum of clinical findings identified in this study that can collectively be associated with homicidality. A large number of patients with LD have no aggressive tendencies or only mild degrees of low frustration tolerance and irritability, pose no danger to society, and should not be stigmatized. This study can help explain and prevent some previously unexplainable violence and homicide and has broader implications. Understanding the role of Lyme and other infections in causing violence, and prevention, diagnosis, and treatment can help reduce some violence and promote peace.

Introduction

Background

Lyme disease (LD) is the most common tick-borne disease, which is a spirochete, and LD has been compared to syphilis and labeled the New Great Imitator since it may present as many different medical conditions.1,2 The Lyme Borrelia has been found in 15 million-year-old fossilized ticks and in the 5,300-year-old Iceman in the Italian Alps.3,4 LD is transmitted by Ixodes ticks and is the most common tick-borne disease.5 Although Ixodes ticks and Borrelia are present throughout the world, there are regional differences in Borrelia species, tick populations, tick-borne coinfections, and infection rates. In the past 30 years, there has been an expanding awareness of a broad spectrum of neuropsychiatric symptoms that invariably evolve in the later stages of these infections and may include cognitive, emotional, and behavioral symptoms. The diagnosis of LD is often overlooked, and it is increasingly common for psychiatrists to make the initial diagnosis.6–11

LD, or Lyme borreliosis, is a tick-borne infectious disease caused by Borrelia burgdorferi, Borrelia garinii, or Borrelia afzelii while the term Lyme borreliosis/tick-borne diseases recognize that there may also be other tick-borne pathogens and secondary opportunistic infections causing a complex pathophysiological process.

No study has ever before attempted to examine the association between aggressiveness, violence, homicidality, homicide, and LD. A recent article on suicide and Lyme and associated diseases revealed that 68% of LD patients acquired some form of aggressiveness, including 11% who became homicidal after infection, and 26% of the suicidal patients were also homicidal.12 Based upon this finding, a further assessment of aggression and homicidality in LD patients was indicated.

Currently there is a tendency to deal with aggressiveness more through punitive approaches rather than scientific understanding and proactive prevention. Weapon technology is more advanced than our capability to understand and prevent violence, and this limitation is a serious concern when atomic and other weapons of mass destruction may be in the hands of individuals or groups at risk for violent behavior. Therefore, every contributor to violence needs to be better understood and addressed.

Defining aggression and violence

The word aggression may refer to either healthy adaptive emotional effort or more commonly violent maladaptive behavior. Healthy adaptive aggression exists throughout the animal kingdom and is an integral part of human behavior. It includes the pursuit of life, liberty, and happiness and the drives for territoriality, social integration, and reproduction. Social cooperation and respectful competition are an integral part of adaptive aggression and healthy human and societal functioning. A healthy individual in a healthy society values social cooperation and respectful competition over violence as a means of achieving goals.

Anger is an emotion characterized by antagonism toward someone, oneself, or something. Violence can be defined as the use of physical force, power, or threat with the intent to harm or injure another person, oneself, or a group or community, or the destruction of property. Rage is violent, uncontrolled anger. Characteristics of violent acts include self-directed violence (suicidal behavior and self-abuse), interpersonal violence (family – child, partner, elder, or community – acquaintance, and stranger), and collective violence (social, political, and economic). The nature of violent acts can include physical, sexual, psychological, and involving deprivation or neglect.13 Sometimes aggression is used as a synonym for violence. Homicide is the act of one human killing another.

Contributors, deterrents, and triggers of violence

It can rarely be stated that there is only one single cause in any given violent act. Violent behavior is the result of an interaction of multiple contributors, deterrents, acute triggers, and many different sequential events, some of which are both known and unknown (Figure 1).

Figure 1

The presence or absence of violence is the interactive result of all the multisystem acute and chronic contributors and deterrents to violence.

Some of the well-recognized contributors to violence include homelessness, social isolation, being single, living alone, gang membership, low education, unemployment, incarceration, history of violent behavior, fascination with weapons, being a victim of violence, opposing beliefs (religious, political, ethnic, and lifestyle), exposure to violence, exposure to media and computer games with violent themes, younger age, intoxication of potential victim, response of the potential victim, gender, genes (monoamine oxidase A, catechol-O-methyltransferase, serotonin transporter gene, FK506 binding protein s, XYY), threat sensitivity, grudge holding, victim blaming, childhood abuse, child conduct disorder, multiple psychiatric diagnoses (intermittent explosive disorder, narcissistic personality disorder, antisocial personality disorder, psychopathy, bipolar illness, depression, social communication disorder, and other conditions), longer duration of untreated psychosis, cognitive dysfunction, treatment non-adherence, substance abuse, cannabis use, intoxication, head injuries, toxicity, endocrine disorders, limbic encephalitis, Wilson’s disease, brain infections, brain tumors, neurological impairments, and sensory and motor impairments.14–18 One hundred percent of death row inmates had both neurological impairments and a history of abuse.19–21

Deterrents to violence include empathy, frustration tolerance, cognitive abilities, restraint capabilities, higher education, coping skills, supportive relationships, community and other social connections, ethical and religious beliefs, access to social services and psychiatric and medical care, and social structure.22

Triggering events can include acute stress, apperception of threat, jealousy, obsession, psychotic delusions, post-traumatic flashbacks, hopelessness, competition, exposure to violence, traumatic brain injury, unintentional injury, being suicidal, self-harm, impairment from substance use, intoxication, and losing a parent.23,24

While acknowledging the significance of all of these other components to violence, the scope of this article shall specifically focus upon violence and LD.

Epidemiology of violence and infections

Globally, ~1.6 million people die each year because of violence.13,25 Currently violence is not equally distributed throughout the world.26 Peace correlates strongly with education, health, and economic opportunity, and health correlates with a lower prevalence of infectious disease.27 Cognitive impairments contribute to violence, and higher cognitive functioning is a deterrent to violence. There is a strong correlation between national intelligence quotient and lower parasite stress. As countries overcome infectious diseases, the intelligence of their citizens increases; this helps explain the Flynn Effect.28 One study sampled 20 European nations and demonstrated that the prevalence of the brain parasite Toxoplasma gondii was positively associated with national homicide rates.29,30

Violence and infections: historical perspective

Violence is a significant part of history. Death due to violence was much more common in prehistoric societies, in which it was estimated that 10% died because of homicide. Throughout history, violence has decreased as civilization has advanced with increases in literacy, education, democratic governments, and health.31 Different parts of the world at different times in history had different rates of violence in individuals and groups. Poor hygiene correlates with a higher rate of infectious diseases, which in turn correlates with a greater prevalence of violence. The greater prevalence of violence in a critical mass of individuals and influential individuals may contribute to collective violence and wars at different times in history.32

Influential leaders considered to have mental symptoms from syphilis impacting their behavior include Joseph Stalin, Adolf Hitler, Ivan the Terrible, Idi Amin Dada, Benito Mussolini, Henry VIII, Al Capone, Napoleon Bonaparte, Vladimir Lenin, Pope Alexander VI, Charles VIII of France, Peter the Great, and Catherine the Great.33–36

Types of violence

Two basic types of violence are individual violence and collective or group violence. Individual violence involves one person directing violence against others. Collective or group violence is acts committed by normal people and includes situational collective violence which is unplanned and spontaneous, organized collective violence that is unofficial and lacking government approval, and institutional collective violence which is directed by legally constituted officials.

Individual violence can be categorized into three major types – impulsive (or affective), psychotic, and predatory (or psychopathic). Some individual violent acts may be a combination of more than one of these categories. Impulsive violence, also called disorders of impulse control or affective violence is reactive, emotional, rapid and unplanned in response to a real or perceived perception of threat with intense autonomic arousal without regard for long-term consequences. Psychotic violence is motivated by a persecution belief, and there may be an attack against imagined enemies. Paranoia, paranoid schizophrenia, and drug-induced paranoid states are included in this category. Predatory violence is planned, purposeful, and emotionless without autonomic arousal. Impaired functioning contributes to violence in all the three categories, which include impairments of cognition, threat perception, autonomic arousal, impulse control, empathy, and reality testing.14,37

The characteristics of violent acts include self-directed violence and interpersonal violence. Self-directed violence can include suicidal behavior and self-abuse. Interpersonal violence can include family and intimate partner violence (child, partner, and elder), community violence (acquaintance and stranger), and collective violence (social, political, and economic). The nature of violent acts includes physical, sexual, psychological, and/or involving deprivation or neglect.13,38

Impaired and violent individuals or groups of impaired and violent individuals may also contribute to causing collective violence on others who are normal healthy individuals if these impaired individuals are in positions of leadership or influence upon other normal healthy individuals. Leaders or influential individuals prone to predatory violence are particularly dangerous which may result in genocide.32

Neural circuitry of violence

Although a detailed review of all the known neural circuits and transmitters involved in violence is beyond the scope of this article, some general concepts deserve attention. In a state of health, higher level cortical and limbic functioning has sufficient control over more primitive limbic and hypothalamic functioning. Higher level brain functioning integrates many feedforward and feedback pathways that are both stimulatory and inhibitory. Injury to a higher center can result in a dysfunction or a loss of a function leading to a decline in adaptive abilities. Injury to an inhibiting pathway will cause a decline or an inability to inhibit that function. In individuals prone to violence, higher level neural circuits associated with civilized behavior have insufficient control over more primitive mammalian and reptilian neural circuits.39

The right ventromedial prefrontal cortex integrates cognition and affect which contributes to mediating the empathic response.40 The orbital frontal cortex contributes to constraining impulsive outbursts, while the anterior cingulate cortex recruits other brain regions in the response to conflict. Parts of the amygdala are involved in the production of a fear response and other negative emotions. Other parts of the amygdala recognize fear, social emotions, and multiple other emotions in facial expressions as demonstrated by impaired recognition of emotions of social significance following amygdala damage.41,42

In impulsive violence, cortical functioning generally has insufficient control over lower level functioning. This failure of the prefrontal cortex to modulate aggressive acts triggered by anger-provoking stimuli combined with a hyper-responsive amygdala and other limbic regions that are part of affective reactivity contributes to impulsive violence.43 Brain activity in the orbital and anterior regions (impulse control) were blunted or entirely absent in many violent offenders, while the amygdala (fear) showed normal or heightened activity. The inability of the two brain regions to effectively balance the response of the amygdala may help explain how threatening situations can become explosive in some people.44 Brain imaging in murderers supports this model and demonstrates reduced activity in the prefrontal cortex as well as the superior parietal cortex, left angular gyrus, and corpus callosum.45

In psychotic aggression, there is also a hypoactive prefrontal cortex but in contrast to impulsive violence there is invariably normal limbic drive and striatal hyperactivity.14,46 In predatory aggression, there is also a hypoactive prefrontal cortex, but instead a hypoactive limbic system and amygdala.14,46

Particularly violence is correlated with intrusive symptoms, which is relevant to impulsive, predatory, and psychotic aggression. The neural circuit relevant to these symptoms are associated with the activation of basolateral amygdala and ventral hippocampus.47–50 Activation of this circuit also seems to be associated with chronic inflammation with elevated inflammatory markers (tumor necrosis factor-alpha, interleuken-6, interleukin-1β, and C-reactive protein).51–53 LD is associated with chronic inflammation and activation of this circuit.54

Neurochemistry of violence

The neurotransmitters serotonin, dopamine, norepinephrine, acetylcholine, glutamate, and gamma-aminobutyric acid are thought to be involved in violent behavior.14 Particularly serotonin is significant.55–57 Impulsively violent individuals have decreased serotonin activity as demonstrated by significantly lower concentrations of the major metabolite of serotonin, 5-hydroxyindoleacetic acid, in their cerebrospinal fluid.58 Serotonin serves an important inhibitory function in the amygdala, anterior cingulate cortex, dorsolateral prefrontal cortex, and orbitofrontal cortex.59

Inflammatory markers are elevated in individuals with intermittent explosive disorder. Elevations of both plasma C-reactive protein and interleukin-6 levels were significantly elevated in individuals with intermittent explosive disorder compared with psychiatric or normal controls. In addition, these inflammatory markers were directly correlated with a composite measure of aggression and with measures reflecting history of actual aggressive behavior in all individuals.60

Persistence of inflammation is associated with persistent elevations of proinflammatory cytokines, which results in the dysregulation of tryptophan metabolism, that increases quinolinic acid, which is a N-methyl-D-aspartate receptor agonist and this can result in glutamate dysfunction and violent behavior.12

Violence and infections

Violent behavior has been associated with a number of infectious diseases including Spanish flu, encephalitis lethargica, Western equine encephalitis, viral encephalitis, herpes simplex encephalitis, neurosyphilis, cerebral malaria, sepsis, and toxoplasmosis.61–76 In a review of 108 cases of acute viral encephalitis, 23% experienced violence or aggression.77 Criminal behavior as a result of neurological injury has been documented in both acute and chronic infections including neurosyphilis, encephalitis lethargica, herpes simplex encephalitis, AIDS dementia complex, infections causing dementia, and various other viral encephalitides.78–81

T. gondii seropositive individuals have higher aggression and impulsivity scores, which suggests T. gondii changes brain chemistry in a fashion that increases the risk of aggressive behavior. The personality of men infected with T. gondii showed higher apprehension compared to uninfected controls, lower superego strength, and higher vigilance, they were more likely to disregard rules, and were more expedient, suspicious, jealous, and dogmatic. Possible mechanisms by which T. gondii may affect human behavior include its effect on dopamine and on testosterone.82

Parasitic infections have adverse effects throughout life, but are particularly traumatic to the young. Newborn children need 87% of their metabolic energy for brain functioning, while the brains of 5-year-old children consume 87% of their metabolic energy and an adult brain requires approximately a quarter of the body’s energy. In addition to the pathogenic effects of parasites, they also compete for energy which can harm brain development and functioning, which can in turn contribute to violent behavior.28

Violence and infectious diseases in animals

Parasites sometimes manipulate the behavior of hosts in a manner that facilitates their survival and reproduction.83 Sometimes this manipulation includes fostering aggressive behavior.84,85 Historically, rabies has been the main model for infections causing violence in animals.86 In addition, aggression associated with tick-borne infections in animals has been documented with Babesia microti in mice,87 Babesia gibsoni in dogs,88 B. burgdorferi in dogs,89,90 Bartonella henselae in dogs,91 B. henselae in horses,92 and B. burgdorferi in chimpanzees.93,94

In order to study the neuroendocrine effects, work has been done with prairie voles and dogs to understand aggressiveness in animals with selective aggression versus affiliation and bonding in the context of arginine-vasopressin versus oxytocin.95–97 Both the neuropeptides are significant in social behavior, but oxytocin is more associated with affiliation while arginine-vasopressin is more associated with aggression and male behavior.98 In sheep, increased oxytocin results in maternal acceptance while lower levels may result in violent rejection and indifference toward a newborn.99 In humans, low oxytocin levels are associated with alexithymia and anorexia nervosa.100 Arginine-vasopressin and oxytocin are released from the posterior pituitary gland, a part of the brain lacking a blood–brain barrier and more vulnerable to penetration by B. burgdorferi which has been demonstrated in the vasculature in a murine model.101–104

Murine and primate models demonstrated infection of the trigeminal nerve is a transneuronal entry route for brain infections involving temporal lobe and limbic structures.22,105

Violence and LD

More serious cases often involve a complex interactive infection with Lyme borreliosis and other tick-borne coinfections and sometimes the activation of opportunistic viruses and other pathogens. A survey of over 3,000 chronic LD patients demonstrated that over 50% had laboratory-confirmed coinfections and 30% had two or more coinfections, including Babesia (32%), Bartonella (28%), Ehrlichia (15%), Mycoplasma (15%), Rickettsia rickettsia (6%), Anaplasma (5%), and Francisella tularemia (1%). A very similar study of chronic Lyme patients in Canada demonstrated similar coinfection rates.106,107 Although some tick studies show that coinfection rates are relatively low, these findings can be explained since chronically ill patients often report exposure to multiple tick bites.

The first human reference to aggressiveness with tick-borne diseases that could be located was a 1990 study by Logigian et al demonstrating that 26% of chronic Lyme patients had extreme irritability.108 In 1991, Harvey et al described a patient who became aggressive and combative following a Bartonella infection.109 The first reference to homicide associated with LD was a meatpacker who killed his supervisor at a meat-packing plant in Michigan in 1992 and used LD as part of the defense. His identical twin who did not have LD had no neurological deficits or history of violence.110 In 1992, Fallon et al described a man acutely sensitive to sound who was so intensely bothered by the noise of his 3-year-old son that he picked him up and shook him in a sudden and unprecedented fit of violence.111 Sherr described LD patients having sudden personality changes, in people of known character after acquiring LD, including outbursts of anger, breaking doors, cursing at other drivers, and road rage.112 In a publication, a LD patient described an incident where someone else pulled into a parking space that he wanted; he responded by jumping out of his car and knocking the other driver unconscious. Another LD patient was described lunging out of his car after a motorist beeped the horn and he began pounding on the windshield of their car, then suddenly stopped in bewilderment because he did not recall or understand why he was behaving in this manner. Another LD patient was arrested for shoplifting during a state of confusion, and another patient was accused of pedophilia.113

Other media reports include: a LD patient who stalked, threatened to rape, and made repeated threats against multiple political candidates;114 a LD patient committed sexual acts with his 9-year-old son;115 a LD patient shot at police after a 911 call;116 a LD patient was charged with assault associated with marital conflicts;117 and there have been multiple additional references to aggressiveness, violence, homicidality, and homicide associated with LD.6,9,54,113,118–136

In one presentation, 26 different individuals with LD committing multiple violent acts including multiple assaults on police officers and 11 homicides were described.137 Violent behavior seen with LD included homicide; suicide; combined homicide and suicide; assaults with a gun, knife, sword, axe, hammer, rocks, and darts; assaulting a sibling’s head with a rock; pedophilia; stalking; child abuse; assault toward teachers and other students; assaults at summer camp; self-inflicted injuries; road rage incidents; domestic violence; torturing household pets; killing pets; armed robbery; fire setting; shoplifting; destroying property with total amnesia of the event afterwards; breaking and attempting to break automobile windshields; and various forms of public lewdness.137

Antibiotic treatment has on occasion provoked aggressive behavior as a result of the Jarisch–Herxheimer reaction.111,138 There were a number of homicides associated with LD in the press. A LD patient strangled his fiancé with a dog leash. He was considered psychotic at the time of the homicide by the examining forensic psychiatrist.139,140 A LD patient bludgeoned his mother to death while she was sleeping.141 There was a murder, suicide of a couple with advanced LD who also killed the pet dog.142 There was a LD homicide in a Shelter Island in which a Lyme patient killed a longtime friend. The news release states, “Norstrom stated ‘in my own research in the past dozen years we’ve seen a lot of this.’”143–145

In a further communication with Norstrom, he gave consent to publish the following information. He has worked with a very large number of LD patients; he described a significant number of patients with aggressive behavior, such as women who had told him they wanted to hurt their children and did not know why; an easygoing man is arrested for a brawl who had no history of abuse; a teenager who became involved in physical altercations with peers, parents, and teachers; people who never said hell or damn going into a rage; children breaking the bones of their sibling, throwing a TV set through a window, destroying their bedroom, picking fights with classmates; and a teenager who went to a neighbor’s house and attacked him with a hammer because he thought the neighbor was going into his house. He stated he could list hundreds of other similar examples. Noise was magnified and certain pitches, a whiney voice, a squeak in a gate hinge, a barking dog, a crowd of people’s voices seem to bring on irrational behavior (Nostrom SJ, founder and director of Lyme borrelia Out-Reach Foundation, personal communication, August, 2008).

There were indications the shooter at the Sandy Hook Elementary School massacre, Adam Lanza, may have had LD, however the medical examiner failed to pursue LD assessment.146–148 LD has been a valid defense in the legal system.149 LD has been used as a defense in assaults, such as detonating a fertilizer bomb and an axe attack.150,151

When discussing homicide associated with LD, it is more common to think of a LD patient with a mental impairment who kills another person; however, there are other homicides associated with LD. In one case, the wife of a debilitated LD patient assisted in the planning and implementation of his suicide and pleaded guilty to felony murder.152 In reviewing other legal cases involving fatalities, LD patients who were inadequately diagnosed and treated earlier in their illness became debilitated with chronic pain, developed opioid dependence and abuse, and died from opioid overdoses.153

In a prior study analyzing the prevalence of findings, patients who were both homicidal and suicidal demonstrated low frustration tolerance (100%), cognitive symptoms (100%), sudden mood swings (93%), generalized anxiety (90%), explosive anger (83%), disinhibition (80%), panic disorder (80%), paranoia (76%), depersonalization (76%), hypervigilance (72%), anhedonia (72%), intrusive images (48%), obsessive compulsive disorder (48%), hallucinations (45%), substance abuse (28%), posttraumatic stress disorder (PTSD) (24%), and dissociative episodes (18%).12 In another presentation evaluating children with LD, 53% had anger/irritability, 25% had rages/explosive behavior, 54% had panic attacks, and 50% had mood swings.154

Neural circuitry of violence and infections

Infections and the associated immune provocation can sometimes alter the functioning of cortical, limbic, and brainstem functioning. Brain regions and associated circuits particularly significant to aggressive potential include the amygdala, the right ventromedial prefrontal cortex, the orbitofrontal cortex, the anterior cingulate, and the ventral hippocampus.53,155,156 The amygdala is involved in fear responsiveness and other negative emotions, the right ventromedial prefrontal cortex mediates empathic responsiveness, and the orbital frontal cortex plays a crucial role in constraining impulsive outbursts, while the anterior cingulate cortex recruits other brain regions in response to conflict, and the basolateral amygdala and ventral hippocampus are significant with traumatic memory.

Infectious encephalopathies are most commonly associated with impulse control disorders and predominately white matter encephalopathies with dysfunction of the prefrontal cortex and limbic structures. LD is commonly associated with white matter dysfunction, and many patients have explosive anger. Intermittent explosive disorder is associated with lower white matter integrity of the superior longitudinal fasciculus and density and lower white matter integrity in long-range connections between the frontal and temporoparietal regions.157

A certain type of temporal lobe and amygdala damage is strongly associated with predatory aggression in which there is impaired recognition of social emotions. This type of aggression has many similarities to Kluver–Bucy syndrome, which is a rare condition associated with temporal lobe injury and dysfunction. It includes visual agnosia, excessive oral tendencies, hypermetamorphosis, placidity, altered sexual behavior, and changes in dietary habits.158 Psychopathic and serial killers display visual agnosia and consistently lack normal empathetic human interpersonal recognition, and humans are not human to them.159 Kluver–Bucy syndrome is caused by a number of conditions including head injuries and a number of infections that injure the temporal lobes. These infections include Mycoplasma pneumoniae, tubercular meningitis, herpes simplex encephalitis, herpes meningoencephalitis, tick-borne infections, Epstein–Barr virus, and neurocysticercosis.160–170

Infections and aggression: psychoimmunology and neurochemistry

From an evolutionary medicine perspective, zoonotic parasites that manipulate the aggressive and social behavior of hosts achieve this by altering the actions of serotonin, dopamine, and norepinephrine, but in particular serotonin.171 Persistent infections and the immune reactions to them are associated with chronic inflammation and sometime autoimmune reactions.

Persistent inflammation is associated with increased interleukin-6 and interleukin-1 beta, reduced serotonin as demonstrated by reduced 5 hydroxy-indoleacetic acid, and increased quinolinic acid which is a N-methyl-D-aspartate receptor agonist that contributes to glutamate dysregulation and can result in both aggressive and self-destructive behavior (the death formula).12,172,173 These immune and associated biochemical findings have been seen in a number of infections associated with violence, including LD, cerebral malaria, and HIV.53,54,174 Other evidence supporting the association between inflammation and aggression includes hepatitis C treatment with interferon alpha, which can be associated with irritability, impulsiveness, hostility, aggression, anger, emotional lability, and relapse of substance abuse.175–177

Autoimmune reactions are also associated with aggression, and they have been seen in cases of pediatric autoimmune diseases associated with Streptococcal infections, M. pneumoniae and human herpesvirus 7 encephalitis, limbic encephalitis, and anti-N-methyl-D-aspartate receptor encephalitis.178–182

Materials and methods

The author specializes in treating treatment-resistant psychiatric illnesses and some of the patient charts include patients with LD. A total of 1,000 inactive charts of patients with LD from the author’s practice were retrospectively reviewed. Three groups of charts were reviewed, and aggregate data were collected – of those involving LD and aggressiveness, 50 homicidal LD subjects were compared with 50 who were not homicidal, and charts involving homicide were analyzed in more detail.

In the first part of the study, the charts of patients who had aggressive thoughts, impulses, and/or behaviors were selected and reviewed. These charts were reviewed for documentation or statements giving insight into the pathophysiology. All but two were from the United States.

In the second part of the study, the charts were screened until 50 charts of LD patients with homicidality with completed neuropsychiatric assessments were identified. Fifty randomly selected charts of LD patients who were not homicidal were selected as a control group. None of these control charts were used in the previous study on suicidality, and all were from the United States.12 These patients were evaluated with a comprehensive assessment including premorbid assessment, history of tick exposure, history of the presence of erythema migrans rash, early tick-borne disease symptoms, symptoms in the course of illness, current status with a comprehensive neuropsychiatric and general medical assessment, review of systems using the 280-item Neuropsychiatric Lyme Assessment with pattern recognition, and a review of laboratory assessment, which may include enzyme-linked immunosorbent assay, immunofluorescent assay, Western blot, DNA-based testing, coinfection testing, single-photon emission tomography, magnetic resonance imaging, or other diagnostic testing to determine the diagnosis in compliance with the Institute of Medicine–recognized guidelines.183–187 In addition to diagnostic criteria, the patients who met Center for Disease and Prevention surveillance criteria were noted, which is more stringent criteria and captureŝ10% of LD cases.188

Only testing from laboratories validated by the Clinical Laboratory Improvement Amendments of the US Department of Health and Human Services Centers for Medicare and Medicaid Services was considered valid. This is sometimes confused with the US FDA clearance for mass marketed test kits which does not validate the fundamental accuracy of the test but instead demonstrates it is comparable to other similar tests that may or may not have been properly validated in the first place. Charts in which the diagnosis of LD was unclear were excluded from the study. Names were converted to an identifier before entering the findings into a database of individual participant data. The charts were then reviewed with their identity protected to extract aggregate data, including findings relevant to homicidality and aggression, and were analyzed. The baseline health status of each of these two groups before infection was compared with the postinfection findings and the clinical findings of the subjects who were homicidal were compared with the subjects who were not homicidal. Symptoms associated with risk were ranked by comparing the prevalence of different findings among the two different groups.

Data collection included age, sex, diagnosed by comprehensive criteria, Center for Disease Control and Prevention surveillance criteria, years before diagnosis and antibiotic treatment, coinfections, comorbid conditions, pre-existing symptoms before infection, misdiagnoses, number of homicides, attention deficits, auditory hyperacusis, other sensory hyperacusis, memory impairments, processing impairments, dyslexia symptoms, facial memory, depersonalization, derealization, intrusive aggressive images, intrusive sexual images, nightmares, hallucinations, executive functioning impairments, decreased frustration tolerance, sudden abrupt mood swings, hypervigilance, paranoia, disinhibition, exaggerated startle reflex, explosive anger, suicidal tendencies, homicidal tendencies, decline in social relationships, decline in school or work productivity, marital and/or family problems, substance abuse, legal problems, dissociative episodes, depression, rapid cycling bipolar disorder episodes, panic disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, PTSD, sleep disorders, anhedonia, cranial nerve symptoms, seizures, neuropathy, incontinence, decreased libido, irritable bladder, genital pain, chronic pain, and intolerance to alcohol.

The data of the impairments were charted and calculated to the 95% confidence interval (CI). The total impairments of all the 100 patients analyzed was charted preinfection and postinfection, and the 95% CI was calculated for each impairment. The incidence of each psychiatric symptom was calculated for the homicidal versus the non-homicidal groups.

In addition, homicides involving LD were reviewed in greater detail and categorized in regard to the type of homicide (impulsive, psychotic, or predatorial), and additional information was extracted. All the patients were from the United States.

The data were then abstracted to assess the association between aggression, violence, and homicide and LD to create a model for aggressiveness, violence, and homicidality in LD patients to possibly explain and ultimately prevent such an association, if it is found.

Ethical considerations

The Meridian Health Institutional Review Board, Neptune, NJ, USA, approved this study (IRB # 201704192J). Patient consent to review their medical records was not required by the Institutional Review Board as there was minimal risk to subjects, no subject identifiers or links to identifiers were used or collected, and it was a retrospective chart review of already existing data.

Results

Retrospective chart review: aggressiveness

A total of 1000 charts of LD patients were screened to identify charts documenting aggression. All but two were from the US. These charts were then reviewed to identify patterns of aggressiveness. This part of the study was not a statistical analysis of frequency, dominance, or general occurrence of the behaviors discussed.

The most commonly reported aggression with LD was impulsive, sometimes provoked by intrusive symptoms, sensory stimulation or frustration and was invariably bizarre and senseless. Aggression occurred both in homes and in public settings. Some of the aggressive patients had temporal lobe dysfunction, sometimes accompanied with partial seizures. Acute episodes of rage, sometimes referred to as “Lyme rage,” were reported and were witnessed on multiple occasions. The anger during these episodes had a very abrupt onset and was extremely intense and often with minimal cognitive control.

Patients described horrific intrusive symptoms. At night, they would take the form of vivid nightmares. During the day, these intrusive symptoms could be intrusive images, thoughts, and/or impulses. A typical description is that these intrusive symptoms include descriptions of frightening, stabbing, horrific images, usually of death, dying, or pain and suffering. They could be gory and unreal as in a horror story with faces with blood or terror exaggerated, awful expressions. They are described as people in the worse possible situation, perhaps close to death. These images can then evolve into visions of stabbing or killing, most commonly of people close or familiar to the person. A number of patients have described intrusive thoughts of killing multiple family members and themselves. Representative cases include a young adolescent with seizures who had repeated urges to kill their younger sibling. Another patient who had frequent temporal lobe seizures had intrusive thoughts of killing with an axe or knife any female he had a relationship with and described a mechanism in their head that would say kill her, kill her. These thoughts were invariably ego dystonic. The same patient also had thoughts of killing infant and adult female family members. In some cases, the aggression can be particularly toward women. Some patients described intrusive bizarre sexual and pedophilic thoughts and impulses. Others also described sudden and unprovoked urges to harm family members, and sometimes these episodes would be preceded by feeling a sense of derealization. Patients also describe intrusive and unprovoked episodes of anger with an urge to destroy. One patient described sudden urges to rip the room apart and kill everyone and every animal in the house. The intrusive episodes are often described as being episodic and not continuous. The images do not seem to necessarily be associated with a particular trigger, and one patient described them as invading the privacy of their mind.

Patients described fear of their suicidal and homicidal rage. It is described as rage that comes out of nowhere and takes over their whole body, with no control over it. In some, it is worse when they are driving. Some patients are scared for the people who come in contact with them and are afraid the thoughts will become even worse. Patients have described episodes of anger that would occur suddenly and totally unprovoked. A patient described looking at someone and feeling anger for no reason whatsoever, for example, looking at someone in a restaurant and having an urge to hurt the person. A patient described road rage out of nowhere and fantasies of beating and killing people. Patients have also described obsessions where they wished they had an excuse to go after someone. Another patient had an intrusive urge to throw a baby off of a balcony. He was particularly frightened when he had these urges in the presence of children and considered suicide to prevent himself from killing anyone.

One patient described that his pain was so bad, and he wanted to take it out on everyone else. Another patient who developed an impairment of empathy and was highly sensitive to perceived injury expressed, “if someone hurts me, I want to hurt them back. I want to make them cry. I want them to feel my pain.” Others responded to the intrusive homicidal and harmful impulses by becoming suicidal or self-destructive in an effort to prevent themselves from harming others. One patient accused his family members of being imposters.

Frequently, the thoughts or impulses to harm are preceded by being overstimulated, often by sound. For example, a normally passive individual who is an animal lover has hyperacusis and has intrusive hostile imagery of killing the dog by bludgeoning, suffocation, stabbing, or poisoning when it howled. Another patient responded to the neighbor’s dog barking by opening the window and screaming death threats to the dog. After acting in that manner, the patient began crying uncontrollably and wanted to die. Another patient described intrusive, overpowering very violent thoughts which sometimes would be triggered by stimulation; such as a dog barking, a bird chirping, a strobe light, or the presence of other people. Another patient described that the noise of her neighbors playing sports was unbearable. She had an urge to go to the neighbors and start screaming wildly. Sound is not the only trigger. A patient described sitting at a table with guests and her father behind her. When the father called for the dog, the patient became startled, punched her father and screamed at him with a total lack of control.

Not all aggressiveness is described as being provoked by stimulation. Some LD patients are intolerant to alcohol and/or react strongly to low doses of psychotropics or have idiosyncratic reactions to them. Some episodes are associated with the combination of the effects of LD and exposure to a number of medications and/or alcohol. A number of legal cases have involved bizarre and aggressive behavior while under the effects of alcohol and/or medications.

A few patients who had acquired LD as a congenital infection or were infected at a very young age had significantly impaired recognition of emotions of social significance and had difficulty processing interpersonal cues. They would sometimes take offense when normal limits were set on them. This occasionally resulted in a perceived injury, a rapid escalation of agitation, and because of their impaired capacity for empathy, it would sometimes result in assaultive behavior. Violent behavior seemed more problematic when the illness began in young children who have no memory to serve as a reference point for healthy functioning. There were a number of cases involving children infected at a young age that were quite severe. In these cases, psychopathic traits are evident, and the patients may repeatedly assault their family members, damage their house, knock over furniture, and kick and punch holes through walls and doors. Frequent police intervention was needed with these patients. In these cases, there is often a lack of empathy and a lack of remorse for their behavior. With antibiotic and psychotropic treatment, the impulse control disorder can improve, but sometimes lack of empathy and lack of remorse can persist.

The oldest legal case that could be found involving LD was in 1993, in which the patient was treated and the legal charges were dismissed. A number of cases were managed in a similar manner over a span of years. There were a number of shoplifting cases, mostly involving females. There were a few cases involving fire setting. In one case, the patient burned down his house as a result of a paranoid delusion. Some individuals with psychotic symptoms acted bizarrely and were repeatedly drawing the attention of the legal system and occasionally SWAT (special weapons attack team) teams. A few patients attacked multiple police officers in a bizarre and senseless manner.

Retrospective chart review: homicidality

Inactive charts were reviewed until 50 LD subjects with homicidal tendencies were identified, that is, 520 charts were screened until 50 cases could be identified (9.6%). A few of these charts had a few incomplete data points. There were 98% (N=49) of the subjects who were also suicidal. In this group of 50 homicidal patients, there were five homicides. The subjects who committed homicides were incarcerated and evaluated in forensic settings. Forty nine of the 50 homicidal patients were not homicidal before being infected with LD. It is possible one patient may have been homicidal before being infected with LD. The average age was 35 years (youngest 11 years and oldest 63 years). The average age of onset of illness was 26 years. There were 52% male and 48% female subjects, and 10% were diagnosed immediately after infection, but had inadequate initial treatment. The average subject experienced a delay of 9 years before diagnosis and treatment. There were 22% of subjects that were diagnosed in ≤2 years. The longest length of time before diagnosis was 40 years. There were 66% that met Center for Disease and Prevention Surveillance Criteria for Lyme disease. All who committed homicides met the Surveillance Criteria. There were 84% of subjects misdiagnosed at some point, and the misdiagnoses included “all in your head,” “just nuts,” “laziness,” “nervousness,” “hyper,” “a witch in another life,” “psychiatric,” “everything,” bipolar depression, depression, major depression, panic disorder, anxiety attacks, alcoholism, attention deficit disorder, pervasive developmental disorder, PTSD, anxiety, intermittent explosive disorder, adjustment reaction, obsessive compulsive disorder, oppositional defiant disorder, multiple sclerosis, brain tumor, Alzheimer’s disease, visual labyrinthitis, headaches, sensory motor dysfunction syndrome, migraine syndrome, sciatica, bulging disc, dysautonomia, orthostatic intolerance, seizure disorder, amyotrophic lateral sclerosis, vertigo, Meniere’s disease, chronic fatigue/immune deficiency syndrome, fibro-myalgia, lupus, arthritis, rheumatoid arthritis, mononucleosis, bronchitis, asthma, fever of unknown origin, erythromelalgia, systemic candidiasis, food allergies, and flu.

Coinfections in this group in order of frequency included Babesia, Anaplasma, Bartonella, Ehrlichia chaffeensis, Epstein–Barr virus, cytomegalovirus, mycoplasma, Rickettsia rickettsii, and Hepatitis C.

An additional 50 charts of LD patients who were not homicidal were randomly selected, and the prevalence of symptoms was compared with the prevalence of the same symptoms in LD patients who were homicidal. In this group, the average age was 42 years (youngest 8 years and oldest 67 years). There were 44% of male and 56% of female subjects. About 10% were diagnosed immediately after infection, but had inadequate initial treatment. The average subject experienced a delay of 8.1 years before diagnosis and treatment. There were 32% who were diagnosed in ≤2 years. The greatest length of time before diagnosis was 39 years. There were 74% meeting Center for Disease and Prevention Surveillance Criteria. Misdiagnosis had occurred in 92% of these subjects.

Both the groups of patients in this study were generally quite healthy compared with the general population, preinfection; however, postinfection, both the groups developed significant cognitive symptoms, emotional symptoms, vegetative symptoms, behavioral symptoms, neurological symptoms, musculoskeletal symptoms, cardiovascular symptoms, gastrointestinal symptoms, urogenital symptoms, and other symptoms. Coinfections in this group in order of frequency included Babesia, Bartonella, E. chaffeensis, Anaplasma, mycoplasma, R. rickettsii, Epstein–Barr virus, Chlamydia pneumoniae, and Coxiella burnetii.

Comparing the two groups, it was found that there were significant differences in the prevalence of psychiatric symptoms, behavioral symptoms, psychiatric syndromes, cognitive symptoms, neurological symptoms, and urogenital symptoms. Not all symptoms that were studied showed a statistically significant separation between the two groups that might explain homicidality or appeared relevant to violence. These symptoms included attention deficits, auditory hyperacusis, other sensory hyperacusis, facial memory impairments, executive functioning impairments, decreased frustration tolerance, fatigue, sleep disorder, decline in social relationships, decline in school or work productivity and chronic pain. A number of signs, symptoms and syndromes associated with violent risk were increased in the homicidal group and these findings were further analyzed. The 95% CI was calculated for each data point (Table 1).

Table 1

The homicidal group had more impairments postinfection

50 homicidal and 50 non-homicidal Lyme disease patients
Findings	Homicidal group		Non-homicidal group
	Preinfection, % (95% Cl)	Postinfection, % (95% CI)	Preinfection, % (95% Cl)	Postinfection, % (95% Cl)
Psychiatric symptoms
Suicidal	2 (0–6)	98 (94–100)	0 (0–0)	46 (32–60)
Sudden abrupt mood swings	4 (0–9)	94 (87–100)	0 (0–0)	66 (53–79)
Explosive anger	4 (0–9)	91 (83–99)	0 (0–0)	52 (38–66)
Paranoia	0 (0–0)	88 (79–97)	0 (0–0)	36 (23–49)
Ahedonia	2 (0–6)	86 (76–96)	0 (0–0)	56 (42–70)
Hypervigilance	2 (0–6)	84 (74–94)	0 (0–0)	54 (40–68)
Exaggerated startle	2 (0–6)	84 (74–94)	0 (0–0)	66 (53–79)
Disinhibition	2 (0–6)	84 (74–94)	0 (0–0)	32 (19–45)
Nightmares	2 (0–6)	82 (71–93)	0 (0–0)	58 (44–72)
Depersonalization	0 (0–0)	71 (58–84)	0 (0–0)	52 (38–66)
Intrusive images aggressive	4 (0–9)	62 (49–75)	0 (0–0)	16 (6–26)
Hallucinations	2 (0–6)	47 (33–61)	0 (0–0)	42 (28–56)
Dissociative episodes	0 (0–0)	38 (25–51)	0 (0–0)	12 (3–21)
Derealization	0 (0–0)	37 (24–50)	0 (0–0)	24 (12–36)
Intrusive images sexual	2 (0–6)	26 (14–38)	0 (0–0)	6 (0–13)
Behavioral symptoms
Marital/family problems	0 (0–0)	80 (69–91)	0 (0–0)	48 (34–62)
Legal problems	0 (0–0)	42 (28–56)	0 (0–0)	4 (0–9)
Substance abuse	6 (0–13)	33 (20–46)	0 (0–0)	10 (2–18)
Psychiatric syndromes
Depression	6 (0–13)	98 (94–100)	0 (0–0)	76 (64–88)
Panic disorder	2 (0–6)	82 (71–93)	2 (0–5.9)	50 (36–64)
Social anxiety disorder	4 (0–9)	66 (53–79)	4 (0–9.4)	70 (57–83)
OCD	2 (0–6)	51 (37–65)	2 (0–5.9)	32 (19–45)
PTSD	6 (0–13)	36 (23–49)	2 (0–5.9)	24 (12–36)
Rapid bipolar	0 (0–0)	28 (16–40)	0 (0–0)	10 (2–18)
Cognitive symptoms
Memory impairments	0 (0–0)	98 (94–100)	0 (0–0)	76 (64–88)
Processing impairments	0 (0–0)	94 (87–100)	0 (0–0)	78 (67–89)
Dyslexia symptoms	4 (0–9)	78 (67–89)	0 (0–0)	68 (55–81)
Neurological symptoms
Neuropathy	0 (0–0)	92 (84–100)	0 (0–0)	70 (57–83)
Cranial nerve symptoms	0 (0–0)	92 (84–100)	0 (0–0)	66 (53–79)
Seizures	0 (0–0)	20 (9–31)	0 (0–0)	24 (12–36)
Urogential
Decreased libido	0 (0–0)	80 (69–91)	4 (0–9.4)	44 (30–58)
Irritable bladder	4 (0–9)	56 (42–70)	2 (0–5.9)	44 (30–58)
Intolerance to alcohol	0 (0–0)	44 (30–58)	0 (0–0)	24 (12–36)
Incontinence	2 (0–6)	38 (25–51)	2 (0–5.9)	18 (7–29)
Genital pain	0 (0–0)	32 (19–45)	0 (0–0)	24 (12–36)

Abbreviations: CI, confidence interval; OCD, obsessive compulsive disorder; PTSD, posttraumatic stress disorder.

Both the homicidal and non-homicidal groups showed an increase of all the impairments studied preinfection versus postinfection (95% CI) (Table 2).

Table 2

All impairments were increased postinfection

Total patient group (n=100) pre vs postinfection
Findings	Preinfection, % (95% Cl)	Postinfection, % (95% CI)
Psychiatric symptoms
Sudden abrupt mood swings	2 (0–6)	80 (69–91)
Exaggerated startle	1 (0–4)	75 (63–87)
Suicidal	1 (0–4)	72 (60–84)
Explosive anger	2 (0–6)	72 (59–84)
Ahedonia	1 (0–4)	71 (58–84)
Nightmares	1 (0–4)	70 (57–83)
Hypervigilance	1 (0–4)	69 (56–82)
Paranoia	0 (0–0)	62 (49–75)
Depersonalization	0 (0–0)	62 (48–75)
Disinhibition	1 (0–4)	58 (44–72)
Hallucinations	1 (0–4)	45 (31–58)
Intrusive images aggressive	2 (0–5)	39 (29–49)
Derealization	0 (0–0)	31 (18–43)
Dissociative episodes	0 (0–0)	25 (13–37)
Intrusive images sexual	1 (0–4)	16 (6–26)
Behavioral symptoms
Marital/family problems	0 (0–0)	64 (51–77)
Legal problems	0 (0–0)	23 (11–35)
Substance abuse	3 (0–8)	22 (10–33)
Psychiatric syndromes	0 (0–0)	0 (0–0)
Depression	3 (0–8)	87 (78–96)
Social anxiety disorder	4 (0–9)	68 (55–81)
Panic disorder	2 (0–6)	66 (53–79)
OCD	2 (0–6)	42 (28–55)
PTSD	4 (0–9)	30 (17–43)
Rapid bipolar	0 (0–0)	19 (8–30)
Cognitive symptoms
Memory impairments	0 (0–0)	87 (78–96)
Processing impairments	0 (0–0)	86 (76–96)
Dyslexia symptoms	2 (0–6)	73 (61–85)
Neurological symptoms
Neuropathy	0 (0–0)	81 (70–92)
Cranial nerve symptoms	0 (0–0)	79 (68–90)
Seizures	0 (0–0)	22 (11–33)
Urogential
Decreased libido	2 (0–6)	62 (49–75)
Irritable bladder	3 (0–8)	50 (36–64)
Intolerance to alcohol	0 (0–0)	34 (21–47)
Incontinence	2 (0–6)	28 (16–40)
Genital pain	0 (0–0)	28 (16–40)

Abbreviations: CI, confidence interval; OCD, obsessive compulsive disorder; PTSD, posttraumatic stress disorder.

The homicidal group had a greater incidence of all the psychiatric symptoms studied when compared to the non-homicidal group. The mean of the psychiatric symptoms was 71% in the homicidal versus 41% in the non-homicidal group (Figure 2).

Figure 2

All the psychiatric symptoms were greater in the homicidal versus the non-homicidal group.

Retrospective chart review: homicide

In reviewing the LD charts involving both LD and homicide, 10 homicides were identified. None of these homicides were cases discussed when reviewing media reports in the “Background” section. Three of the 10 homicides involved suspected LD that was not confirmed, and these cases were not included in the study. The other seven homicides were associated with well-confirmed cases of LD. All seven victims had a prior personal relationship with the perpetrators, either real or imagined by the perpetrator. Two of these cases did not have completed neuropsychiatric assessments and were included in the retrospective chart review of homicides but were not included in the retrospective data analysis of homicidal LD patients.

Of the seven homicides, one was a combined homicide, dog killing, and suicide, which seemed to have been related to impulsivity. Also there were other homicide, dog killing, and suicide cases which occurred that were not evaluated by the author.189,190 Another homicide was associated with psychosis, and the other five had predatory features. In a predatory case, the Lyme enzyme-linked immunoassay was 6.83 (positive ≥ 1.10). Whenever these cases involving homicide were tested for coinfections, there was positive reactivity to coinfections, which included Bartonella, Babesia, mycoplasma, Anaplasma phagocytophilum, E. chaffeensis, and viral coinfections. All cases involving predatory aggression also included a history of reported abuse. Findings also included head injuries, social communication impairments, an impaired capacity to bond and empathize with others, social isolation, a fascination with knives, less than a normal amount of anxiety, fire setting, and torturing animals prior to the homicides. In all of the LD cases involving homicide, there were obstacles preventing both adequate antibiotic and psychiatric treatments.

Discussion

Upon reviewing the existing literature and the retrospective chart reviews, LD patients postinfection may acquire a number of impairments that are collectively associated with an increased risk of violence and homicidality, but some acquired impairments are more likely to increase risk than others. In spite of having impairments, the majority of LD patients are able to compensate and may only demonstrate low frustration tolerance and irritability. Some, however, demonstrate more severe symptoms. To better understand why many LD patients are not aggressive, while others can be highly aggressive, it is necessary to look at the different symptoms seen in these two groups.

For organizational purposes, the data are presented as cognitive impairments, emotional impairments, behavioral symptoms, psychiatric syndromes (multiple brain regions), neurological impairments, and somatic impairments.

Individuals with cognitive impairments have less coping skills and in general can have increased risk for violence. Among the homicidal subjects in this study, 98% had impaired capacity for sustained and/or selective attention; 88% had auditory hyperacusis (misophonia); 86% had sensory hyperacusis to light, touch, and/or smell; 98% had memory impairments (most commonly working memory and short-term memory); 94% had processing impairments; 78% had dyslexia symptoms; and 98% had executive functioning memory impairments. Sensory hyperacusis is associated with an impaired capacity to filter incoming stimulation, resulting in a sensory overload, and contributes to making a patient more reclusive and socially isolated and also contributes to them being more emotionally reactive to stimulation that average people can easily tolerate. Some patients have selective hyperacusis to mouth sounds, which I propose may possibly be the result of a disinhibition of a primitive fear of oral predation from brain dysfunction. Facial memory impairments were similar in both the homicidal and non-homicidal groups and seems to be non-contributory. However, patients with more violent potential had an impairment of emotional recognition when they saw a familiar person, and this impairment would sometimes result in their accusations that family and friends were imposters (Capgras’ syndrome).191

Individuals with certain emotional impairments can have greater risk for aggressiveness. Among the homicidal subjects in this study, 71% had depersonalization, 37% had derealization, 62% had intrusive aggressive images, 26% had intrusive sexual images, 82% had vivid nightmares, 47% had hallucinations, 98% had decreased frustration tolerance, 94% had sudden abrupt mood swings, 84% had hypervigilance, 88% had paranoia, 84% had disinhibition, 84% had exaggerated startle reactions, 91% had explosive anger, 38% had dissociative episodes, and 86% had anhedonia.

Individuals with certain behavioral symptoms can have greater risk for aggressiveness. Among the homicidal subjects in this study, 98% were suicidal, 91% had a decline in social functioning, 90% had a decline in school or work productivity, 80% had marital and/or family problems, 33% had substance abuse, and 42% had legal problems.

Individuals with certain psychiatric syndromes can have greater risk for aggressiveness. Among the homicidal subjects in this study, 98% had depression, 28% had rapid cycling bipolar illness, 82% had panic disorder, 51% had obsessive compulsive disorder, 66% had social anxiety disorder, 86% had generalized anxiety disorder, and 36% had PTSD.

Individuals with certain urological symptoms, particularly urinary incontinence (along with torturing animals and fire setting), are considered by some to be at greater risk for predatory aggression. Among the homicidal subjects in this study, 38% had urinary incontinence, 56% had irritable bladder, and 32% had genital pain.

Among the homicidal subjects in this study, 44% had intolerance to alcohol with a more exaggerated response to alcohol consumption. Alcohol intoxication is a well recognized risk for violence and homicide.192

Among the homicidal subjects in this study, other symptoms that were present but may or may not correlate with homicidal risk included 96% with sleep disorders, 38% with decreased libido, 92% with cranial nerve symptoms, 92% with neuropathy, 20% with seizures (mostly complex partial), 48% with chronic pain, and 92% with fatigue.

Violent behavior was more problematic when the illness began in young children who had no memory to serve as a reference point for healthy functioning.

Although data are limited in two of the homicide cases, it seems in the cases involving homicides that there were other contributors to violence; however, it also seems that these homicides would not have occurred if the perpetrators had not had neurological deterioration as a result of LD.

Multiple patients described intrusive thoughts, images, and impulses to kill everything, including themselves. These descriptions have similarities to the episodes in which the individuals attempt to kill everyone and everything, including house pets and themselves. The pathophysiology behind this process may be the result of the previously described death formula (persistent infection→persistent proinflammatory cytokines→dysregulation of tryptophan metabolism→quinolinic acid→N-methyl-D-aspartate receptor agonism→glutamate dysregulation→neural circuit dysfunction→psychiatric dysfunction→suicidal and/or homicidal tendencies) which may be a pathophysiological explanation of the death drive (Thantos) concept that was first proposed by Spielrein and further advanced by Freud.12,193 It is unclear why a few LD patients develop the collective risk contributors for violence, but most do not. Possible explanations include the following – there is a genetic vulnerability that is triggered in only some who become infected, some other pathogen or pathogens other than Borrelia (either tick-borne or opportunistic within the host microbiome) may be responsible for causing the aggressiveness or it may be more the immune reaction to the infection rather than the infection itself that is causative, and this immune reaction may have multiple other causes. In this study, there was no clear difference in the coinfections in the homicidal versus the non-homicidal group.

In synthesizing these findings, the following model for violence and LD can be constructed (Figures 3 and 4).

Figure 3

Violence results from the interactive effects of contributors, failed deterrents, and acute triggers.

Figure 4

Violence is more likely to occur in Lyme disease patients when there is a greater number and severity of the contributors to violence combined with compromised deterrents and acute triggers.

There are multiple mechanisms through which infection may contribute to violence, and many seem to be immune mediated. Impairments associated with infectious disease that can contribute to violent behavior include decreased frustration tolerance; decreased impulse control; cognitive impairments; sensory hyperacusis; hypervigilance; paranoia; increased startle reflex, particularly increased acoustic startle; sudden abrupt mood swings; impairment in the ability to regulate emotional arousal levels; social anxiety disorder when contributing to social isolation; obsessive compulsive disorder combined with intrusive thoughts, images, and compulsions that are of aggressive nature and/or sexually aggressive nature; hyposexuality and hypersexuality, both of which cause increased interpersonal frustration; suicidal and homicidal preoccupations, intrusive images, and urges; decreased bonding capacity; decreased empathy; decreased emotional insight; depersonalization; derealization; dissociative states; illusions; delusions; hallucinations and decreased tolerance to the effects of drugs and alcohol.

Conclusion

Violent behavior is the result of a complex interaction of many contributors, failures of deterrents, and acute triggering events. From evolutionary, geographical, epidemiological, and historical perspectives, multiple studies, case reports, and animal studies, some infections can be associated with violence. These infections have psychoimmune and pathophysiological implications through multiple mechanisms that include proinflammatory and autoimmune mechanisms that can cause multiple impairments impacting brain neurochemistry and neural circuit functioning which can cause different types of violence. LD can be one of the many infectious contributors associated with aggressiveness, violence, homicidality, and homicide. There is support for this from journal citations, presentations, animal studies, psychoimmunology, neurochemistry, neural circuity, reports, and observations. Delays in diagnosing and treating LD may result in an increased risk of aggressiveness that can result in impulsive, psychotic, and/or predatory aggression. Most violence seen with LD seems to be impulsive, bizarre, and senseless.

The most common case is a young male with impairments during development who lacks a reference point of mature healthy functioning before the onset of impairment who may be at greater risk for violence if he was infected at a younger age and has impaired recognition of emotions of social significance and difficulty processing interpersonal cues.

LD causes a number of impairments that collectively increase the risk of homicidality. Postinfection findings associated with homicidality that separated from the non-homicidal group within the 95% CI included suicidality, sudden abrupt mood swings, explosive anger, paranoia, anhedonia, hypervigilance, exaggerated startle, disinhibition, nightmares, depersonalization, intrusive aggressive images, dissociative episodes, derealization, intrusive sexual images, marital/family problems, legal problems, substance abuse, depression, panic disorder, memory impairments, neuropathy, cranial nerve symptoms, and decreased libido. Although predatory aggression with LD seems to be an uncommon presentation, it accounts for the greatest number of homicides. A patient who acquires LD and is inadequately diagnosed and treated may be at risk for committing homicide if they have a history of reported abuse, head injuries, social communication impairments, an impaired capacity to bond and empathize with others, social isolation, a fascination with knives, less than a normal amount of anxiety, fire setting, torturing animals, and obstacles preventing adequate antibiotic and psychiatric treatment.

Some patients have selective hyperacusis to mouth sounds, which I propose may possibly be the result of brain dysfunction causing a disinhibition of a primitive fear of oral predation.

As with the vast majority of patients with mental illness, many patients with LD have no aggressive tendencies or only mild degrees of low frustration tolerance and irritability and pose no danger to society. A lesser number experience marital and family conflicts, a lesser number experience explosive anger, a lesser number experience homicidal thoughts and impulses, and a much lesser number commit homicides. Since such a large number of individuals are affected by LD, this small percent of LD cases can be significant and is a cause for concern.

Many of the patients who became aggressive and homicidal responded to effective treatment, and much of the violence associated with LD can be avoided with better prevention, diagnosis, and treatment of LD. Although this article focused upon violence associated with LD, violence associated with other infectious diseases are also significant, and greater research into the association between infections and violence is strongly recommended. Human history is also a history of violence. Understanding violence and recognizing the role of microbes and psychoimmunology opens new opportunities to prevent violent behavior, suffering, crime, war, and social discord and protect peace. We need a multidisciplinary mobilization of our scientific community to better understand all the facets of violence to prevent future tragedies similar to the approach used to understand and prevent airplane crashes.