Sandra Maria Barbalho1, Ricardo José Tofano2, André Luis de Campos2, Aniele Sanches Rodrigues3, Karina Quesada4, Marcelo Dib Bechara4, Ricardo de Alvares Goulart3, Marie Oshiiwa5. 1. Department of Biochemistry and Nutrition-Medical School of Marília-UNIMAR, Av. Higino Muzzi Filho 1001, Marília, 15525-902, Sao Paulo, Brazil; Department of Biochemistry-School of Food Technology (FATEC), Marília, 17506-000, Sao Paulo, Brazil. Electronic address: smbarbalho@gmail.com. 2. Cardiologist of the Cardiac Surgery Unit and Hemodynamics-Medical School, Av. Higino Muzzi Filho 1001, Marília, São Paulo, Brazil. 3. Medical School, Av. Higino Muzzi Filho 1001, Marília, São Paulo, Brazil. 4. Department of Biochemistry and Nutrition-Medical School of Marília-UNIMAR, Av. Higino Muzzi Filho 1001, Marília, 15525-902, Sao Paulo, Brazil. 5. Department of Biochemistry-School of Food Technology (FATEC), Marília, 17506-000, Sao Paulo, Brazil.
Abstract
BACKGROUND: The concern with the incidence of chronic-degenerative diseases is increasing worldwide, and many studies have shown that insufficiency of vitamin D (VD) can be linked to several metabolic disorders. AIMS: Thus, the objective of this study was to evaluate the association of the metabolic syndrome risk factors, atherogenic indices and VD in a group of patients attended at a Cardiology Center. METHODS: For this study, we invited 200 patients of both sexes attended in a Cardiology Center (Medical School of Marilia - São Paulo - Brazil). Most were female (n = 111) and aged between 41 and 70 years (from march to august, 2017). RESULTS: Our results showed that only 20.0% of the patients presented normal levels of VD. Patients with altered values for this vitamin presented significantly higher values for glycemia, HbA1c, Total cholesterol, LDL-c, triglycerides, Castelli Index I, Castelli Index II, Body Mass Index, waist circumference, non-HDL-c and the estimative of the size of the LDL-c particle. Vitamin D correlated negatively with glycemia, HbA1C, triglycerides, atherogenic indices, Body Mass Index, and blood pressure. Multiple Regression Model showed that for an individual to maintain metabolic parameters, at least at borderline values, the levels of VD should be 37.64 that is not in accordance with the reference values. CONCLUSIONS: These results showed a remarkable prevalence of low concentrations of Vitamin D in patients with cardiovascular risk factors.
BACKGROUND: The concern with the incidence of chronic-degenerative diseases is increasing worldwide, and many studies have shown that insufficiency of vitamin D (VD) can be linked to several metabolic disorders. AIMS: Thus, the objective of this study was to evaluate the association of the metabolic syndrome risk factors, atherogenic indices and VD in a group of patients attended at a Cardiology Center. METHODS: For this study, we invited 200 patients of both sexes attended in a Cardiology Center (Medical School of Marilia - São Paulo - Brazil). Most were female (n = 111) and aged between 41 and 70 years (from march to august, 2017). RESULTS: Our results showed that only 20.0% of the patients presented normal levels of VD. Patients with altered values for this vitamin presented significantly higher values for glycemia, HbA1c, Total cholesterol, LDL-c, triglycerides, Castelli Index I, Castelli Index II, Body Mass Index, waist circumference, non-HDL-c and the estimative of the size of the LDL-c particle. Vitamin D correlated negatively with glycemia, HbA1C, triglycerides, atherogenic indices, Body Mass Index, and blood pressure. Multiple Regression Model showed that for an individual to maintain metabolic parameters, at least at borderline values, the levels of VD should be 37.64 that is not in accordance with the reference values. CONCLUSIONS: These results showed a remarkable prevalence of low concentrations of Vitamin D in patients with cardiovascular risk factors.
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