| Literature DB >> 29576480 |
Anna Staffas1, Marina Burgos da Silva1, Ann E Slingerland1, Amina Lazrak1, Curtis J Bare2, Corey D Holman2, Melissa D Docampo3, Yusuke Shono1, Benjamin Durham4, Amanda J Pickard5, Justin R Cross5, Christoph Stein-Thoeringer1, Enrico Velardi1, Jennifer J Tsai1, Lorenz Jahn1, Hillary Jay1, Sophie Lieberman1, Odette M Smith1, Eric G Pamer6, Jonathan U Peled7, David E Cohen2, Robert R Jenq8, Marcel R M van den Brink9.
Abstract
Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT. Depletion of the intestinal microbiota resulted in impaired recovery of lymphocyte and neutrophil counts, while recovery of the hematopoietic stem and progenitor compartments and the erythroid lineage were largely unaffected. Depletion of the intestinal microbiota also reduced dietary energy uptake and visceral fat stores. Caloric supplementation through sucrose in the drinking water improved post-BMT hematopoietic recovery in mice with a depleted intestinal flora. Taken together, we show that the intestinal microbiota contribute to post-BMT hematopoietic reconstitution in mice through improved dietary energy uptake.Entities:
Keywords: antibiotics; bone marrow cell transplantation; hematopoiesis; hematopoietic recovery; immune reconstitution; intestinal flora; microbiota; nutrition
Mesh：
Year: 2018 PMID： 29576480 PMCID： PMC5897172 DOI： 10.1016/j.chom.2018.03.002
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023