Bin Yang1, Peng Xu2, Yichao Shi3, Jixiu Xu4, Lianwen Zheng5, Haisong Li6, Lianghong Ma7, Shenmin Yang8, Yong Zhao9, Yan Zhang10, Qiang Du11, Qingjun Chu12, Bin Chen13, Yan Tan14, Xiangru Li15, Chaobin Li16, Fa Sun17, Yongtong Zhu12, Hongjun Li18. 1. Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. 2. Reproductive Center of Jinghua Hospitals, Shenyang Oriental Medical Group, Shenyang, Liaoning, China. 3. Center for Reproduction, Changzhou Number 2 People's Hospital, affiliated with Nanjing Medical University, Changzhou, Jiangsu, China. 4. Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. 5. Reproductive Center of the Second Hospital of Jilin University, Changchun, Jilin, China. 6. Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. 7. Department of Urology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. 8. Center for Reproduction and Genetics, Suzhou Municipal Hospital, Suzhou Hospital, affiliated with Nanjing Medical University, Suzhou, Jiangsu, China. 9. Reproductive Medical Center, Navy General Hospital, Beijing, China. 10. Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 11. Department of Reproduction, ShengJing Hospital of China Medical University, Shenyang, Liaoning, China. 12. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. 13. Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 14. Department of Andrology, the People's Hospital of Shiyan, Shiyan, Hubei, China. 15. Andrology Clinic, Shengli Hospital of Shengli Petroleum Administrative Bureau, Dongying, Shandong, China. 16. Department of Andrology, Woman and Child Health Hospital, Baoji, Shanxi, China. 17. Department of Urology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China. 18. Department of Urology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. Electronic address: lihongjun@pumch.cn.
Abstract
BACKGROUND: Knowledge on the occurrence of erectile dysfunction (ED) and timely ovulatory intercourse failure (TOIF) in Chinese men of infertile couples is limited. AIM: To obtain representative estimates of ED and TOIF in Chinese men of infertile couples and to analyze potential risk factors associated with ED. METHODS: 4,299 Chinese men of infertile couples with an average age of 32.85 ± 5.98 years were surveyed using the 5-item International Index of Erectile Function (IIEF-5) questionnaire for their ED occurrence. Multiple logistic regression analysis was used to disclose risk factors associated with ED. OUTCOMES: The occurrence of ED was 57.8% and that of TOIF was up to 26.2% in Chinese men of infertile couples. RESULTS: Based on IIEF-5 criteria, 34.9% of men had mild ED and only 2.6% had severe ED. Secondary infertility, infertility with known causes, and chronic prostatitis were significant risk factors associated with ED. TOIF was significantly higher (23.3%) in men of infertile couples with ED than in those without ED (8.6%), indicating that TOIF is likely a contributing factor to male infertility. CLINICAL IMPLICATIONS: Understanding the occurrence and types of ED and TOIF in men of infertile couples and their associated risk factors will help physicians treat clinical cases of male infertility more effectively. STRENGTHS AND LIMITATIONS: Large numbers of infertile outpatients from multiple hospital clinics across the country were included in this study. The concept of TOIF was raised for the 1st time and studied preliminarily in Chinese men of infertile couples. The lack of participants' psychological status, a control group of men of fertile couples, and measurement of testosterone levels was a limitation in this clinic-based study. CONCLUSION: The occurrence of ED was higher in Chinese men of infertile couples than in the general Chinese male population. Yang B, Xu P, Shi Y, et al. Erectile Dysfunction and Associated Risk Factors in Chinese Males of Infertile Couples. J Sex Med 2018;15:671-677.
BACKGROUND: Knowledge on the occurrence of erectile dysfunction (ED) and timely ovulatory intercourse failure (TOIF) in Chinese men of infertile couples is limited. AIM: To obtain representative estimates of ED and TOIF in Chinese men of infertile couples and to analyze potential risk factors associated with ED. METHODS: 4,299 Chinese men of infertile couples with an average age of 32.85 ± 5.98 years were surveyed using the 5-item International Index of Erectile Function (IIEF-5) questionnaire for their ED occurrence. Multiple logistic regression analysis was used to disclose risk factors associated with ED. OUTCOMES: The occurrence of ED was 57.8% and that of TOIF was up to 26.2% in Chinese men of infertile couples. RESULTS: Based on IIEF-5 criteria, 34.9% of men had mild ED and only 2.6% had severe ED. Secondary infertility, infertility with known causes, and chronic prostatitis were significant risk factors associated with ED. TOIF was significantly higher (23.3%) in men of infertile couples with ED than in those without ED (8.6%), indicating that TOIF is likely a contributing factor to male infertility. CLINICAL IMPLICATIONS: Understanding the occurrence and types of ED and TOIF in men of infertile couples and their associated risk factors will help physicians treat clinical cases of male infertility more effectively. STRENGTHS AND LIMITATIONS: Large numbers of infertile outpatients from multiple hospital clinics across the country were included in this study. The concept of TOIF was raised for the 1st time and studied preliminarily in Chinese men of infertile couples. The lack of participants' psychological status, a control group of men of fertile couples, and measurement of testosterone levels was a limitation in this clinic-based study. CONCLUSION: The occurrence of ED was higher in Chinese men of infertile couples than in the general Chinese male population. Yang B, Xu P, Shi Y, et al. Erectile Dysfunction and Associated Risk Factors in Chinese Males of Infertile Couples. J Sex Med 2018;15:671-677.
Keywords:
5-Item International Index of Erectile Function; Erectile Dysfunction; Male Infertility; Risk Factors; Timely Ovulatory Intercourse Failure (TOIF)
Authors: Paolo Capogrosso; Christian Fuglesang S Jensen; Giulia Rastrelli; Josep Torremade; Giorgio I Russo; Amr Abdel Raheem; Anders Frey; Mikkel Fode; Mario Maggi; Yacov Reisman; Carlo Bettocchi; Giovanni Corona Journal: Sex Med Date: 2021-06-02 Impact factor: 2.491