AIM: To comprehensively evaluate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9) level for colorectal cancer (CRC). METHODS: Both of the relationships between MMP-9 level and CRC and the diagnostic value were evaluated from 12 eligible papers. RESULTS: The high MMP-9 level increased CRC risk. The estimated sensitivity and specificity were 69 and 68%, respectively, which signified that the diagnostic value was medium. Diagnostic odds ratio and the area under the receiver operating characteristic curve suggested MMP-9 level has a moderate diagnostic value in CRC. Additionally, the likelihood matrix indicated MMP-9 levels could be considered as a biomarker for the diagnosis of CRC. CONCLUSION: Patients with CRC have elevated MMP-9 levels, which is a potential biomarker for CRC diagnosis.
AIM: To comprehensively evaluate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9) level for colorectal cancer (CRC). METHODS: Both of the relationships between MMP-9 level and CRC and the diagnostic value were evaluated from 12 eligible papers. RESULTS: The high MMP-9 level increased CRC risk. The estimated sensitivity and specificity were 69 and 68%, respectively, which signified that the diagnostic value was medium. Diagnostic odds ratio and the area under the receiver operating characteristic curve suggested MMP-9 level has a moderate diagnostic value in CRC. Additionally, the likelihood matrix indicated MMP-9 levels could be considered as a biomarker for the diagnosis of CRC. CONCLUSION:Patients with CRC have elevated MMP-9 levels, which is a potential biomarker for CRC diagnosis.
Authors: Saverio Candido; Barbara Tomasello; Alessandro Lavoro; Luca Falzone; Giuseppe Gattuso; Angela Russo; Sabrina Paratore; James A McCubrey; Massimo Libra Journal: Front Cell Dev Biol Date: 2022-09-21