Naomi Mataki1,2,3, Atsuo Tomidokoro4, Makoto Araie1,2, Aiko Iwase3. 1. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan. 2. Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Setagaya, Tokyo, Japan. 3. Tajimi Iwase Eye Clinic, Tajimi, Gifu, Japan. 4. Higashi Nakano Tomidokoro Eye Clinic, Nakano, Tokyo, Japan.
Abstract
PURPOSES: To assess β-zone of peripapillary atrophy (β-PPA) and its relationship between systemic and ocular factors, especially glaucoma, in a Japanese population. METHODS: Fundus photographs obtained from 2129 normal, 84 primary open-angle glaucoma (POAG) and 10 primary angle closure glaucoma subjects from 3021 participants aged 40 years or older in the Tajimi Study were analysed planimetrically. If both eyes of a subject met inclusion criteria, one eye was randomly chosen. RESULTS: The presence rates of β-PPA were 54.7 and 77.4% (p < 0.001) and β-PPA area averaged 0.67 and 1.06 mm2 (p < 0.001), in normal and POAG eyes, respectively. Myopia was closely related to disc ovality and β-PPA. In normal eyes, logistic analysis showed that the presence of β-PPA was correlated with older age, female gender, myopic refraction, thicker central corneal thickness (CCT), greater disc ovality and disc centre to fovea (disc-fovea) distance and lower intraocular pressure (IOP) (p = 0.039 ~ <0.001); and multiple regression analysis showed that β-PPA area was correlated with older age, myopic refraction, greater disc area and ovality, disc-fovea distance and lower IOP (p = 0.004 ~ <0.001) after adjusting other factors. CONCLUSIONS: The presence and size of β-PPA in normal eyes were correlated with older age, greater disc ovality and disc-fovea distance and lower IOP. Further, its presence was associated with female gender, thicker CCT and its size with greater disc area. β-zone of peripapillary atrophy (β-PPA) was also associated with POAG. These results provide reference data of the β-PPA in a Japanese population and possibly indicate clinical importance of β-PPA in glaucoma clinic.
PURPOSES: To assess β-zone of peripapillary atrophy (β-PPA) and its relationship between systemic and ocular factors, especially glaucoma, in a Japanese population. METHODS: Fundus photographs obtained from 2129 normal, 84 primary open-angle glaucoma (POAG) and 10 primary angle closure glaucoma subjects from 3021 participants aged 40 years or older in the Tajimi Study were analysed planimetrically. If both eyes of a subject met inclusion criteria, one eye was randomly chosen. RESULTS: The presence rates of β-PPA were 54.7 and 77.4% (p < 0.001) and β-PPA area averaged 0.67 and 1.06 mm2 (p < 0.001), in normal and POAG eyes, respectively. Myopia was closely related to disc ovality and β-PPA. In normal eyes, logistic analysis showed that the presence of β-PPA was correlated with older age, female gender, myopic refraction, thicker central corneal thickness (CCT), greater disc ovality and disc centre to fovea (disc-fovea) distance and lower intraocular pressure (IOP) (p = 0.039 ~ <0.001); and multiple regression analysis showed that β-PPA area was correlated with older age, myopic refraction, greater disc area and ovality, disc-fovea distance and lower IOP (p = 0.004 ~ <0.001) after adjusting other factors. CONCLUSIONS: The presence and size of β-PPA in normal eyes were correlated with older age, greater disc ovality and disc-fovea distance and lower IOP. Further, its presence was associated with female gender, thicker CCT and its size with greater disc area. β-zone of peripapillary atrophy (β-PPA) was also associated with POAG. These results provide reference data of the β-PPA in a Japanese population and possibly indicate clinical importance of β-PPA in glaucoma clinic.
Authors: Anton M Kolomeyer; Eli Smith; Ebenezer Daniel; Gui-Shuang Ying; Wei Pan; Max Pistilli; Juan Grunwald; Maureen G Maguire; Benjamin J Kim Journal: Retina Date: 2021-01-01 Impact factor: 3.975