| Literature DB >> 29574902 |
Hyeran Helen Jeon1,2, Quan Yu2,3, Yongjian Lu2,4, Evelyn Spencer2, Chanyi Lu2, Tatyana Milovanova2, Yang Yang2,5, Chenying Zhang2,6, Olga Stepanchenko2, Rameen P Vafa2, Paulo G Coelho7,8, Dana T Graves2.
Abstract
Angiogenesis is a critical aspect of wound healing. We investigated the role of keratinocytes in promoting angiogenesis in mice with lineage-specific deletion of the transcription factor FOXO1. The results indicate that keratinocyte-specific deletion of Foxo1 reduces VEGFA expression in mucosal and skin wounds and leads to reduced endothelial cell proliferation, reduced angiogenesis, and impaired re-epithelialization and granulation tissue formation. In vitro FOXO1 was needed for VEGFA transcription and expression. In a porcine dermal wound-healing model that closely resembles healing in humans, local application of a FOXO1 inhibitor reduced angiogenesis. This is the first report that FOXO1 directly regulates VEGFA expression and that FOXO1 is needed for normal angiogenesis during wound healing.Entities:
Keywords: FOXO; VEGF; angiogenesis; blood vessel; dermal; endothelial; forkhead; minipig; mucosa; skin; vascular endothelial growth factor-A; wound
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Year: 2018 PMID： 29574902 PMCID： PMC6566901 DOI： 10.1002/path.5075
Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996