Masato Nakaguro1, Makoto Urano2, Hiroaki Suzuki3, Kazuyuki Yamada4, Asumi Sakaguchi5, Kanako Ogura5, Toshiharu Matsumoto5, Noritsugu Ono6, Tsuguharu Asato7, Yoshiki Mikami7, Hiroshi Imai8, Toshitaka Nagao9. 1. Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan. 2. Department of Diagnostic Pathology, Fujita Health University, School of Medicine, Toyoake, Japan. 3. Department of Diagnostic Pathology, National Hospital Organisation Hokkaido Cancer Center, Sapporo, Japan. 4. Department of Head and Neck Surgery, National Hospital Organisation Hokkaido Cancer Center, Sapporo, Japan. 5. Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan. 6. Department of Otorhinolaryngology, Juntendo University Nerima Hospital, Tokyo, Japan. 7. Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan. 8. Pathology Division, Mie University Hospital, Tsu, Mie, Japan. 9. Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan.
Abstract
AIMS: Low-grade intraductal carcinoma (LG-IDC) is a clinically indolent malignant tumour of the salivary glands. Because of its rarity, the histological variants of LG-IDC have not been well characterised. Herein, we describe five LG-IDC cases with prominent oncocytic change in the major salivary glands. METHODS AND RESULTS: We examined five cases, three males and two females (mean age = 63 years), of LG-IDC with oncocytic change. The sites affected by LG-IDC were the parotid and submandibular glands. The lesions were macroscopically unilocular or multilocular cysts with a solid tumour arising from the cyst wall. Smaller tumour cell nests were also observed. As with classic LG-IDC, the cyst wall was surrounded by myoepithelial cells with no invasive component. The tumour cells had abundant oncocytic cytoplasm and proliferated in a low-papillary, tubular or cribriform pattern. Immunohistochemically, the tumour cells were diffusely positive for pan-cytokeratin, S100, mammaglobin and antimitochondria antibody, and were negative for androgen receptor and gross cystic disease fluid protein-15. Unlike classic LG-IDC, some of these cases demonstrated focal invagination of myoepithelial cells in the intraductal tumour. CONCLUSION: Oncocytic LG-IDC should be recognised as a histologically unique variant of LG-IDC. Awareness of this entity is important to avoid erroneous diagnosis and inappropriate treatment for histological mimics.
AIMS: Low-grade intraductal carcinoma (LG-IDC) is a clinically indolent malignant tumour of the salivary glands. Because of its rarity, the histological variants of LG-IDC have not been well characterised. Herein, we describe five LG-IDC cases with prominent oncocytic change in the major salivary glands. METHODS AND RESULTS: We examined five cases, three males and two females (mean age = 63 years), of LG-IDC with oncocytic change. The sites affected by LG-IDC were the parotid and submandibular glands. The lesions were macroscopically unilocular or multilocular cysts with a solid tumour arising from the cyst wall. Smaller tumour cell nests were also observed. As with classic LG-IDC, the cyst wall was surrounded by myoepithelial cells with no invasive component. The tumour cells had abundant oncocytic cytoplasm and proliferated in a low-papillary, tubular or cribriform pattern. Immunohistochemically, the tumour cells were diffusely positive for pan-cytokeratin, S100, mammaglobin and antimitochondria antibody, and were negative for androgen receptor and gross cystic disease fluid protein-15. Unlike classic LG-IDC, some of these cases demonstrated focal invagination of myoepithelial cells in the intraductal tumour. CONCLUSION: Oncocytic LG-IDC should be recognised as a histologically unique variant of LG-IDC. Awareness of this entity is important to avoid erroneous diagnosis and inappropriate treatment for histological mimics.
Authors: Kartik Viswanathan; Peter M Sadow; Zahra Maleki; Michiya Nishino; Zubair W Baloch; Todd E Abbott; Rema Rao; William C Faquin Journal: Cancer Cytopathol Date: 2021-10-01 Impact factor: 4.264
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Authors: Adam S Fisch; Israa Laklouk; Masato Nakaguro; Vânia Nosé; Lori J Wirth; Daniel G Deschler; William C Faquin; Dora Dias-Santagata; Peter M Sadow Journal: Hum Pathol Date: 2021-05-12 Impact factor: 3.526