John B Wild1, Mei-Ju Hwang2, Gabriela Jones3. 1. Department of Breast Surgery Worcester Royal Hospital, Worcestershire, UK. j.wild1@nhs.net. 2. Department of Breast Surgery Birmingham City Hospital, Birmingham, UK. 3. Department of Clinical Genetics, Nottingham City Hospital, Nottingham, UK.
Abstract
BACKGROUND: There have been various publications stating that consanguinity both increases and decreases the risk of breast cancer. AIMS: The objective of this study was to determine the impact of consanguinity upon breast cancer. We conducted a systematic review of the literature and meta-analysis. METHODS: Eligible studies were identified on Medline and EMBASE updated to the 19 of September 2017. Studies with sufficient comparative data were included in a meta-analysis. Analyses were carried out using RevMan software. RESULTS: Three comparative studies with a total of 317 individuals with breast cancer and 1459 controls. Reviewing the literature demonstrated conflicting conclusions of the influence of consanguinity upon breast cancer. The meta-analysis showed that there were no statistically significant associations between consanguinity and breast cancer though there was a trend protection from a history of consanguinity. CONCLUSION: Though there is limited literature published on the effects of parental consanguinity, the available data does not demonstrate that it is a risk factor for breast cancer.
BACKGROUND: There have been various publications stating that consanguinity both increases and decreases the risk of breast cancer. AIMS: The objective of this study was to determine the impact of consanguinity upon breast cancer. We conducted a systematic review of the literature and meta-analysis. METHODS: Eligible studies were identified on Medline and EMBASE updated to the 19 of September 2017. Studies with sufficient comparative data were included in a meta-analysis. Analyses were carried out using RevMan software. RESULTS: Three comparative studies with a total of 317 individuals with breast cancer and 1459 controls. Reviewing the literature demonstrated conflicting conclusions of the influence of consanguinity upon breast cancer. The meta-analysis showed that there were no statistically significant associations between consanguinity and breast cancer though there was a trend protection from a history of consanguinity. CONCLUSION: Though there is limited literature published on the effects of parental consanguinity, the available data does not demonstrate that it is a risk factor for breast cancer.
Entities:
Keywords:
Breast cancer; Consanguinity; Inbreeding; Incest; Risk
Authors: Alexander Liede; Imtiaz A Malik; Zeba Aziz; Patricia de los Rios Pd; Elaine Kwan; Steven A Narod Journal: Am J Hum Genet Date: 2002-08-13 Impact factor: 11.025
Authors: Mona M Nabulsi; Hala Tamim; Maha Sabbagh; Mounir Y Obeid; Khaled A Yunis; Fadi F Bitar Journal: Am J Med Genet A Date: 2003-02-01 Impact factor: 2.802
Authors: Hauke Thomsen; Miguel Inacio da Silva Filho; Michael Fuchs; Sabine Ponader; Elke Pogge von Strandmann; Lewin Eisele; Stefan Herms; Per Hoffmann; Andreas Engert; Kari Hemminki; Asta Försti Journal: PLoS One Date: 2016-04-28 Impact factor: 3.240