Stephanie T Grady1, Petros Koutrakis2, Jaime E Hart3, Brent A Coull4, Joel Schwartz5, Francine Laden5, Junfeng Jim Zhang6, Jicheng Gong7, Marilyn L Moy8, Eric Garshick9. 1. Research and Development Service, VA Boston Healthcare System, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: stephanie.grady@channing.harvard.edu. 2. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 3. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 4. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 6. Nicholas School of the Environment, Duke University, Durham, NC, USA. 7. Nicholas School of the Environment, Duke University, Durham, NC, USA; BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China. 8. Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA. 9. Pulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Abstract
OBJECTIVES: We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD). METHODS: Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature. RESULTS: There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22 μg/m3) for 8-OHdG and 1 to 4 days before collection (8.3% increase; 95% CI 0.03-17.3% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4% increase, 95% CI: 3.5-17.9 for 8-OHdG; 8.1% increase, 95% CI: -1.1-18.1 for MDA). Effects on 8-OHdG were greater in obese participants. CONCLUSIONS: We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD. Published by Elsevier Ltd.
OBJECTIVES: We assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD). METHODS: Eighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature. RESULTS: There were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22 μg/m3) for 8-OHdG and 1 to 4 days before collection (8.3% increase; 95% CI 0.03-17.3% per IQR) for MDA. Results were similar in models adjusting for PM2.5 not associated with BC and NO2 (10.4% increase, 95% CI: 3.5-17.9 for 8-OHdG; 8.1% increase, 95% CI: -1.1-18.1 for MDA). Effects on 8-OHdG were greater in obeseparticipants. CONCLUSIONS: We found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obeseparticipants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD. Published by Elsevier Ltd.
Authors: L Barregard; G Sällsten; L Andersson; A-C Almstrand; P Gustafson; M Andersson; A-C Olin Journal: Occup Environ Med Date: 2007-08-17 Impact factor: 4.402
Authors: Adwoa A Commodore; Junfeng Jim Zhang; Yan Chang; Stella M Hartinger; Claudio F Lanata; Daniel Mäusezahl; Ana I Gil; Daniel B Hall; Manuel Aguilar-Villalobos; John E Vena; Jia-Sheng Wang; Luke P Naeher Journal: Environ Int Date: 2013-09-14 Impact factor: 9.621
Authors: H Autrup; B Daneshvar; L O Dragsted; M Gamborg; M Hansen; S Loft; H Okkels; F Nielsen; P S Nielsen; E Raffn; H Wallin; L E Knudsen Journal: Environ Health Perspect Date: 1999-03 Impact factor: 9.031
Authors: Iny Jhun; Jina Kim; Bennet Cho; Diane R Gold; Joel Schwartz; Brent A Coull; Antonella Zanobetti; Mary B Rice; Murray A Mittleman; Eric Garshick; Pantel Vokonas; Marie-Abele Bind; Elissa H Wilker; Francesca Dominici; Helen Suh; Petros Koutrakis Journal: J Air Waste Manag Assoc Date: 2019-08 Impact factor: 2.235
Authors: Carolina L Z Vieira; Petros Koutrakis; Shaodan Huang; Stephanie Grady; Jaime E Hart; Brent A Coull; Francine Laden; Weeberb Requia; Joel Schwartz; Eric Garshick Journal: Environ Res Date: 2019-05-21 Impact factor: 6.498
Authors: Jessica R Deslauriers; Carrie A Redlich; Choong-Min Kang; Stephanie T Grady; Martin Slade; Petros Koutrakis; Eric Garshick Journal: J Expo Sci Environ Epidemiol Date: 2022-01-25 Impact factor: 6.371
Authors: Shichun Huang; Huan Feng; Shanshan Zuo; Jingling Liao; Mingquan He; Masayuki Shima; Kenji Tamura; Yang Li; Lu Ma Journal: Int J Environ Res Public Health Date: 2019-06-26 Impact factor: 3.390
Authors: Osnat Wine; Alvaro Osornio Vargas; Sandra M Campbell; Vahid Hosseini; Charles Robert Koch; Mahdi Shahbakhti Journal: Int J Environ Res Public Health Date: 2022-01-28 Impact factor: 3.390